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Gene Review

CCL23  -  chemokine (C-C motif) ligand 23

Homo sapiens

Synonyms: C-C motif chemokine 23, CK-BETA-8, CK-beta-8, CKB-8, CKb8, ...
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Disease relevance of CCL23


High impact information on CCL23


Chemical compound and disease context of CCL23

  • The inhibitory effect of guanosine 5'-O-(3-thio-triphosphate) (GTP-gammaS) or pertussis toxin pretreatment on MPIF-1 binding and calcium mobilization, respectively, indicates the involvement of G proteins in the interaction of MPIF-1 and its receptor(s) [7].

Biological context of CCL23


Anatomical context of CCL23


Associations of CCL23 with chemical compounds

  • Furthermore, we showed that the CCL23-induced invasion was inhibited by MMP inhibitors such as GM6001 and a specific MMP-2 Inhibitor I [8].
  • In [35S]-GTPgammaS exchange assays, membranes from cells cultured with retinoic acid (4-6 days) were the most responsive to activation by MIP-1alpha and MPIF-1 [13].
  • The proinflammatory stimuli lipopolysaccharide and tumor necrosis factor alpha, which induced the release of monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and interleukin-8, did not affect MPIF-1 release [14].
  • Monocyte and macrophage procoagulants induced by MPIF would contribute significantly to the activation of coagulation which not only results in fibrin deposition but also in the production of activated serine proteases and fibrinopeptides which may potentiate an inflammatory response [3].
  • Murine MPIF is chemically distinct from a number of other well characterized lymphokines in that the two major activities, MPIF alpha and MPIF beta are heparin-binding proteins with high isoelectric points [3].

Other interactions of CCL23

  • The MPIF-1 and MPIF-2 cDNAs were isolated from aortic endothelium and activated monocyte libraries, respectively [4].
  • Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1 [7].
  • MPIF-1 induces a rapid dose-dependent release of [3H]arachidonic acid from monocytes that is dependent on extracellular calcium and is blocked by phospholipase A2 (PLA2) inhibitors [7].
  • Vigilin, a protein found predominantly in cells and tissues with a high biosynthetic capacity, was isolated in its native form from human HEp-2 cells (A.T.C.C. CCL23) by immunoaffinity chromatography [15].
  • In contrast, CD40 ligation and interferon-gamma treatment, while stimulating the production of the other chemokines, caused a pronounced reduction of MPIF-1 transcript and protein release [14].


  1. Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis. Hwang, J., Son, K.N., Kim, C.W., Ko, J., Na, D.S., Kwon, B.S., Gho, Y.S., Kim, J. Cytokine (2005) [Pubmed]
  2. Curcumin suppresses growth of head and neck squamous cell carcinoma. LoTempio, M.M., Veena, M.S., Steele, H.L., Ramamurthy, B., Ramalingam, T.S., Cohen, A.N., Chakrabarti, R., Srivatsan, E.S., Wang, M.B. Clin. Cancer Res. (2005) [Pubmed]
  3. Coagulation and the expression of cell-mediated immunity. Ryan, J., Geczy, C. Immunol. Cell Biol. (1987) [Pubmed]
  4. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. Patel, V.P., Kreider, B.L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R., Garotta, G. J. Exp. Med. (1997) [Pubmed]
  5. Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissection. Anderle, P., Rumbo, M., Sierro, F., Mansourian, R., Michetti, P., Roberts, M.A., Kraehenbuhl, J.P. Gastroenterology (2005) [Pubmed]
  6. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. Rajarathnam, K., Li, Y., Rohrer, T., Gentz, R. J. Biol. Chem. (2001) [Pubmed]
  7. Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. Nardelli, B., Tiffany, H.L., Bong, G.W., Yourey, P.A., Morahan, D.K., Li, Y., Murphy, P.M., Alderson, R.F. J. Immunol. (1999) [Pubmed]
  8. Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. Son, K.N., Hwang, J., Kwon, B.S., Kim, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. Nomiyama, H., Fukuda, S., Iio, M., Tanase, S., Miura, R., Yoshie, O. J. Interferon Cytokine Res. (1999) [Pubmed]
  10. tRNA is entrapped in similar, but distinct, nuclear and cytoplasmic ribonucleoprotein complexes, both of which contain vigilin and elongation factor 1 alpha. Kruse, C., Grünweller, A., Willkomm, D.K., Pfeiffer, T., Hartmann, R.K., Müller, P.K. Biochem. J. (1998) [Pubmed]
  11. CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. Votta, B.J., White, J.R., Dodds, R.A., James, I.E., Connor, J.R., Lee-Rykaczewski, E., Eichman, C.F., Kumar, S., Lark, M.W., Gowen, M. J. Cell. Physiol. (2000) [Pubmed]
  12. CCL23/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrow. Shih, C.H., van Eeden, S.F., Goto, Y., Hogg, J.C. Exp. Hematol. (2005) [Pubmed]
  13. Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL-60 cells: antagonism of hCCR1 activation by MIP-1beta. Chou, C.C., Fine, J.S., Pugliese-Sivo, C., Gonsiorek, W., Davies, L., Deno, G., Petro, M., Schwarz, M., Zavodny, P.J., Hipkin, R.W. Br. J. Pharmacol. (2002) [Pubmed]
  14. Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation. Nardelli, B., Morahan, D.K., Bong, G.W., Semenuk, M.A., Kreider, B.L., Garotta, G. J. Leukoc. Biol. (1999) [Pubmed]
  15. Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin. Kruse, C., Grünweller, A., Notbohm, H., Kügler, S., Purschke, W.G., Müller, P.K. Biochem. J. (1996) [Pubmed]
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