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Gene Review

CCL24  -  chemokine (C-C motif) ligand 24

Homo sapiens

Synonyms: C-C motif chemokine 24, CK-beta-6, Ckb-6, Eosinophil chemotactic protein 2, Eotaxin-2, ...
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Disease relevance of CCL24


High impact information on CCL24


Chemical compound and disease context of CCL24


Biological context of CCL24


Anatomical context of CCL24


Associations of CCL24 with chemical compounds


Physical interactions of CCL24

  • 125I-Eotaxin-2 binds with high affinity to eosinophils and both eotaxin and cold eotaxin-2 displace the ligand with equal affinity [10].
  • A linear peptide corresponding to the N-terminal region of CCR3 binds to eotaxin-2, inducing concentration-dependent chemical shift changes or line broadening of many residues [20].

Regulatory relationships of CCL24


Other interactions of CCL24


Analytical, diagnostic and therapeutic context of CCL24


  1. Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V.L., Soler, D., Williams, T.J., Kay, A.B. J. Immunol. (2002) [Pubmed]
  2. TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells. Zuyderduyn, S., Hiemstra, P.S., Rabe, K.F. J. Allergy Clin. Immunol. (2004) [Pubmed]
  3. Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils. Elsner, J., Petering, H., Kluthe, C., Kimmig, D., Smolarski, R., Ponath, P., Kapp, A. Eur. J. Immunol. (1998) [Pubmed]
  4. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. Papadopoulos, N.G., Papi, A., Meyer, J., Stanciu, L.A., Salvi, S., Holgate, S.T., Johnston, S.L. Clin. Exp. Allergy (2001) [Pubmed]
  5. Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. Schaefer, D., Meyer, J.E., Pods, R., Pethe, W., Hedderich, J., Schmidt, C., Maune, S. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  6. Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Cheadle, E.J., Riyad, K., Subar, D., Rothwell, D.G., Ashton, G., Batha, H., Sherlock, D.J., Hawkins, R.E., Gilham, D.E. Clin. Cancer Res. (2007) [Pubmed]
  7. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. Forssmann, U., Uguccioni, M., Loetscher, P., Dahinden, C.A., Langen, H., Thelen, M., Baggiolini, M. J. Exp. Med. (1997) [Pubmed]
  8. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. Patel, V.P., Kreider, B.L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R., Garotta, G. J. Exp. Med. (1997) [Pubmed]
  9. Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. Ravensberg, A.J., Ricciardolo, F.L., van Schadewijk, A., Rabe, K.F., Sterk, P.J., Hiemstra, P.S., Mauad, T. J. Allergy Clin. Immunol. (2005) [Pubmed]
  10. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. White, J.R., Imburgia, C., Dul, E., Appelbaum, E., O'Donnell, K., O'Shannessy, D.J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N.A., Kaiser, K., Foley, J.J., Schmidt, D.B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G.F., Schleimer, R.P., Sarau, H.M. J. Leukoc. Biol. (1997) [Pubmed]
  11. Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23. Nomiyama, H., Osborne, L.R., Imai, T., Kusuda, J., Miura, R., Tsui, L.C., Yoshie, O. Genomics (1998) [Pubmed]
  12. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. Chae, S.C., Park, Y.R., Oh, G.J., Lee, J.H., Chung, H.T. Immunogenetics (2005) [Pubmed]
  13. The chemokines CCL11, CCL20, CCL21, and CCL24 are preferentially expressed in polarized human secondary lymphoid follicles. Buri, C., Gutersohn, A., Hauser, C., Kappeler, A., Mueller, C. J. Pathol. (2004) [Pubmed]
  14. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Abonyo, B.O., Alexander, M.S., Heiman, A.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  15. Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells. Kagami, S., Saeki, H., Komine, M., Kakinuma, T., Tsunemi, Y., Nakamura, K., Sasaki, K., Asahina, A., Tamaki, K. Clin. Exp. Immunol. (2005) [Pubmed]
  16. Inhibition of CCL11, CCL24, and CCL26-induced degranulation in HL-60 eosinophilic cells by specific inhibitors of MEK1/MEK2, p38 MAP kinase, and PI 3-kinase. Badewa, A.P., Heiman, A.S. Immunopharmacology and immunotoxicology. (2003) [Pubmed]
  17. Detection of mRNA for eotaxin-2 and eotaxin-3 in human dermal fibroblasts and their distinct activation profile on human eosinophils. Dulkys, Y., Schramm, G., Kimmig, D., Knöss, S., Weyergraf, A., Kapp, A., Elsner, J. J. Invest. Dermatol. (2001) [Pubmed]
  18. Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. Berkman, N., Ohnona, S., Chung, F.K., Breuer, R. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  19. CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro. Tachimoto, H., Burdick, M.M., Hudson, S.A., Kikuchi, M., Konstantopoulos, K., Bochner, B.S. J. Immunol. (2000) [Pubmed]
  20. NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2. Mayer, K.L., Stone, M.J. Biochemistry (2000) [Pubmed]
  21. Interleukin (IL)-4 and to a lesser extent either IL-13 or interferon-gamma regulate the production of eotaxin-2/CCL24 in nasal polyps. Lezcano-Meza, D., Dávila-Dávila, B., Vega-Miranda, A., Negrete-García, M.C., Teran, L.M. Allergy (2003) [Pubmed]
  22. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen, F.L., Haye, R., Gran, E., Brandtzaeg, P., Johansen, F.E. J. Immunol. (1999) [Pubmed]
  23. Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma. Rojas-Ramos, E., Avalos, A.F., Pérez-Fernandez, L., Cuevas-Schacht, F., Valencia-Maqueda, E., Terán, L.M. Eur. Respir. J. (2003) [Pubmed]
  24. Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Min, J.W., Jang, A.S., Park, S.M., Lee, S.H., Lee, J.H., Park, S.W., Park, C.S. Chest (2005) [Pubmed]
  25. Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo. Culley, F.J., Brown, A., Conroy, D.M., Sabroe, I., Pritchard, D.I., Williams, T.J. J. Immunol. (2000) [Pubmed]
  26. Regulatory mechanisms of Th2 cytokine-induced eotaxin-3 production in bronchial epithelial cells: possible role of interleukin 4 receptor and nuclear factor-kappaB. Kobayashi, I., Yamamoto, S., Nishi, N., Tsuji, K., Imayoshi, M., Inada, S., Ichiamaru, T., Hamasaki, Y. Ann. Allergy Asthma Immunol. (2004) [Pubmed]
  27. Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. Hashimoto, I., Wada, J., Hida, A., Baba, M., Miyatake, N., Eguchi, J., Shikata, K., Makino, H. Obesity (Silver Spring, Md.) (2006) [Pubmed]
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