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Gene Review

UAP1  -  UDP-N-acetylglucosamine pyrophosphorylase 1

Homo sapiens

Synonyms: AGX, AGX1, AGX2, AgX, Antigen X, ...
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Disease relevance of UAP1


High impact information on UAP1


Biological context of UAP1

  • AgX cDNAs isolated from testis and placenta cDNA libraries (AgX-1 and AgX-2, respectively) differed by a 48-bp deletion in the open-reading frame (ORF) [5].
  • The AgX amino acid sequences contained consensus motifs indicative of NTP binding [5].
  • In the current study, Southern analysis of human genomic DNA with a probe common to the two SPAG2 isoforms indicated a single SPAG2 gene; therefore, alternative splicing is a likely mechanism for production of variant mRNAs [2].
  • However, SPAG2 does not exhibit the molecular characteristics of such proteins, nor does SPAG2 demonstrate sequence homology with previously characterized ODF proteins [2].
  • The molecular structure of all silver halide monomers, Ag(2)X, AgX, AgX(2), and AgX(3), (X = F, Cl, Br, I), have been calculated at the B3LYP, MP2, and CCSD(T) levels of theory by using quasirelativistic pseudopotentials for all atoms except fluorine and chlorine [6].

Anatomical context of UAP1


Associations of UAP1 with chemical compounds

  • However, 3:2 dppa/AgX ratios (X = SbF6. BF4, O3SCF3 or NO3) do lead selectively to new [M2L3] triply bridged cage complexes [Ag2(dppa)3(X)2] 1a-d (X = SbF6 a, BF4 b, O3SCF3 c, NO3 d), which do not exhibit Ag-P bond dissociation at room temperature on the NMR time scale (121 MHz) [9].
  • Abstraction of the chloride ligand from the PCN-based chloromethylrhodium complex 2 by AgX (X=BF(4)(-), CF(3)SO(3)(-)) or a direct C-C cleavage reaction of the PCN ligand 1 with [(coe)(2)Rh(solv)(n)](+)X(-) (coe=cyclooctene) lead to the formation of the coordinatively unsaturated rhodium(III) complexes 3 [10].
  • The preparation of inorganic nanoparticles - Ni(2)B, Pt, Au, Pt-Au, AgX - and the synthesis of organic nanoparticles - cholesterol, rhovanil, rhodiarome - are systematically studied as a function of the concentration of the precursor molecules, the size of the inner water cores, and the manner of mixing the various solutions [11].
  • MEASURES: A solution containing 10 micrograms PGI2/ml was aerosolized by the SPAG-2 aerosol-generator and then introduced into the afferent loop of the ventilatory circuit [12].
  • Five one-dimensional coordination polymers were prepared by the reaction of a bent bridging ligand, bis(4-pyridyl)amine (bpa), with an extensive series of AgX salts (X = CF(3)SO(3), PF(6), ClO(4), NO(3)) [13].

Analytical, diagnostic and therapeutic context of UAP1

  • Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1 [14].
  • An anti-AgX peptide antiserum identified two AgX isoforms on Western blots of human tissue extracts [5].
  • Research of new AgX crystal forms by transmission electron microscopy [15].
  • The authors then developed a new type of wound dressing (AGX), a drug delivery system in which gentamicin is bound to polyvinylalcohol hydrogel through an enzymatically degradable peptide linker containing a -(D)-Phe-Pro-Arg-sequence [7].
  • By using UV thermal denaturation and isothermal titration calorimetry (ITC), we examine the binding behaviors of a hydrogen bond-forming ligand, 2-acetylamino-7-methyl-1,8-naphthyridine (AcMND), with a guanine base opposite an abasic site (AP site) in a DNA duplex (5'-TCC AGX GCA AC-3'/3'-AGG TCG CGT TG-5', X = AP site, G = target) [16].


  1. A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc. Wang-Gillam, A., Pastuszak, I., Elbein, A.D. J. Biol. Chem. (1998) [Pubmed]
  2. Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa. Diekman, A.B., Olson, G., Goldberg, E. Mol. Reprod. Dev. (1998) [Pubmed]
  3. Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. Peneff, C., Ferrari, P., Charrier, V., Taburet, Y., Monnier, C., Zamboni, V., Winter, J., Harnois, M., Fassy, F., Bourne, Y. EMBO J. (2001) [Pubmed]
  4. UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts. Kotake, T., Yamaguchi, D., Ohzono, H., Hojo, S., Kaneko, S., Ishida, H.K., Tsumuraya, Y. J. Biol. Chem. (2004) [Pubmed]
  5. Characterization of a human antigen with sera from infertile patients. Diekman, A.B., Goldberg, E. Biol. Reprod. (1994) [Pubmed]
  6. Structure and bonding in silver halides. A quantum chemical study of the monomers: Ag(2)X, AgX, AgX(2), and AgX(3) (X = F, Cl, Br, I). Müller-Rösing, H.C., Schulz, A., Hargittai, M. J. Am. Chem. Soc. (2005) [Pubmed]
  7. A novel wound dressing with an antibiotic delivery system stimulated by microbial infection. Suzuki, Y., Tanihara, M., Nishimura, Y., Suzuki, K., Kakimaru, Y., Shimizu, Y. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1997) [Pubmed]
  8. Rationale for T cell inhibition by cyclosporin a in major autoimmune diseases. Ferraccioli, G.F., Tomietto, P., DE Santis, M. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  9. Ring-opening polymerisation of silver-diphosphine [M2L3] coordination cages to give [M2L3]infinity coordination polymers. Lozano, E., Nieuwenhuyzen, M., James, S.L. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  10. Interplay between solvent and counteranion stabilization of highly unsaturated rhodium(III) complexes: facile unsaturation-induced dearomatization. Gandelman, M., Konstantinovski, L., Rozenberg, H., Milstein, D. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  11. Mechanism of formation of inorganic and organic nanoparticles from microemulsions. Destr??e, C., B Nagy, J. Advances in colloid and interface science (2006) [Pubmed]
  12. Improvement of oxygenation induced by aerosolized prostacyclin in a preterm infant with persistent pulmonary hypertension of the newborn. Soditt, V., Aring, C., Groneck, P. Intensive care medicine. (1997) [Pubmed]
  13. Helices versus zigzag chains: one-dimensional coordination polymers of Ag(I) and Bis(4-pyridyl)amine. Cordes, D.B., Hanton, L.R., Spicer, M.D. Inorganic chemistry. (2006) [Pubmed]
  14. The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. Mio, T., Yabe, T., Arisawa, M., Yamada-Okabe, H. J. Biol. Chem. (1998) [Pubmed]
  15. Research of new AgX crystal forms by transmission electron microscopy. Novikova, L.A., Kurakin, S.I. Microsc. Res. Tech. (1998) [Pubmed]
  16. Strong binding of naphthyridine derivatives to a guanine base in DNA duplexes containing an AP site. Gao, Q., Satake, H., Dai, Q., Ono, K., Nishizawa, S., Teramae, N. Nucleic acids symposium series (2004) (2005) [Pubmed]
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