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Chemical Compound Review

neuromedin C     (2S)-N-[(1S)-1-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: Grp-10, AC1NUOU7, GRP-10,frog, AKOS015902708, Grp (18-27), ...
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Disease relevance of Grp-10


Psychiatry related information on Grp-10


High impact information on Grp-10

  • RESULTS: Interleukin (IL) 1 beta (50% effective concentration [EC50], 5.3 +/- 0.4 ng/mL) and tumor necrosis factor (TNF) alpha (EC50, 5.5 +/- 0.5 ng/mL) stimulated gastrin release to 50% of the maximal response to 10(-9) mol/L neuromedin C [5].
  • Stimulation by IL-1 beta and TNF-alpha was additive to the responses to neuromedin C and O2-dibutyryl adenosine 3',5'-cyclic monophosphate [5].
  • Isolation of endopeptidase-24.11 (EC, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin [6].
  • Neuromedin C had almost the same bioactivity as GRP with respect to the release of PP, whereas neuromedin B was one-third less potent than GRP and neuromedin C [7].
  • Relative binding affinity of GRP analogues was in the order of GRP (14-27) greater than neuromedin C greater than or equal to BBS greater than or equal to GRP (1-27) greater than neuromedin B (for the later, P greater than 0.05 versus other peptides) [8].

Biological context of Grp-10


Anatomical context of Grp-10


Associations of Grp-10 with other chemical compounds

  • These potencies differed from those for the GRP receptor subtype on rat pancreatic acini [Bn approximately equal to litorin (4 nM) greater than ranatensin, NMC, GRP (15-20 nM) much greater than NMB (351 nM)] [18].
  • The actions of the peptides bombesin (BN), gastrin releasing peptide (GRP), neuromedin C (NMC), litorin and neuromedin B (NMB) were studied on neurons in slices of rat brain maintained in vitro to determine the BN receptor type present in different brain areas [19].
  • The neuropeptide function of neuromedin C and/or other BLI peptides at this level was supported by the stimulatory effect of carbamylcholine (500 microM) on the release of BLI (4.5-fold increase over the basal release of 19 fmol/5 min) from perfused bovine adrenal glands [20].
  • Perifusion of rat anterior pituitary cell aggregates, cultured in estrogen-supplemented serum-free medium with 1 nM of the bombesin (BBN)-like peptide, neuromedin C (NMC), significantly stimulates GH and PRL release [21].
  • All bombesin-like peptides in pmol ranges exhibited potent stimulatory effects on the firing of arcuate neurons, i.e., gastrin-releasing peptide stimulated 90.9% (n = 22), bombesin 78.0% (n = 41), neuromedin C 63.2% (n = 19), ranatensin 58.0% (n = 22), and neuromedin B 50.0% (n = 6) of arcuate neurons tested [22].

Gene context of Grp-10

  • The number of HT-29 cells, partially serum deprived (1% fetal bovine serum) for 48 h, was increased after 24 h of stimulation with bombesin, GRP, neuromedin B (NMB) and neuromedin C (NMC) ranging from 0.1 nM up to 1 microM [23].
  • Bombesin (EC50 6 X 10(-11) M), its mammalian analog GRP-27, and neuromedin C (GRP-10) (EC50 1 X 10(-10) M, for both) were almost equally potent stimuli of somatostatin release, eliciting maximal response at 10(-9) M (400-550% above basal) [24].
  • Comparison of the actions of bombesin, gastrin-releasing peptide-27, neuromedin B, and gastrin-releasing peptide-10 in causing release of gastrin and gastric inhibitory peptide in rats [25].
  • The CCKB/gastrin receptor antagonist CI-988 (1 microM) had no effect on either GRP- or NMC-mediated excitation [19].
  • Bombesin-related peptides which include bombesin, neuromedin B, and neuromedin C induced significant [Ca2+]i transients in RPE cells, whereas other neuropeptides, neuropeptide Y, vasoactive intestinal polypeptide (VIP), and substance P were not effective to produce [Ca2+]i transients [26].

Analytical, diagnostic and therapeutic context of Grp-10


  1. CCK-antagonist L-364,718: influence on rat pancreatic growth induced by caerulein and bombesin-like peptides. Schmidt, W.E., Choudhury, A.R., Siegel, E.G., Löser, C., Conlon, J.M., Fölsch, U.R., Creutzfeldt, W. Regul. Pept. (1989) [Pubmed]
  2. Intrathecal neuromedin C enhances mechanical nociception: possible involvement of NMDA receptors. Onogi, T., Kagawa, M., Minami, M., Kuraishi, Y., Satoh, M. Eur. J. Pharmacol. (1994) [Pubmed]
  3. Effects of neuromedins and related peptides on the body temperature of rats. Itoh, S., Takashima, A., Itoh, T., Morimoto, T. Jpn. J. Physiol. (1995) [Pubmed]
  4. Bombesin, neuromedin C and neuromedin B given intrathecally facilitate the tail flick reflex in the rat. Cridland, R.A., Henry, J.L. Brain Res. (1992) [Pubmed]
  5. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Weigert, N., Schaffer, K., Schusdziarra, V., Classen, M., Schepp, W. Gastroenterology (1996) [Pubmed]
  6. Isolation of endopeptidase-24.11 (EC, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin. Bunnett, N.W., Turner, A.J., Hryszko, J., Kobayashi, R., Walsh, J.H. Gastroenterology (1988) [Pubmed]
  7. Pancreatic polypeptide secretion from the isolated perfused ventral and dorsal areas of the rat pancreas. Miyazaki, K., Funakoshi, A. Gastroenterology (1988) [Pubmed]
  8. Specific binding and growth effects of bombesin-related peptides on mouse colon cancer cells in vitro. Narayan, S., Guo, Y.S., Townsend, C.M., Singh, P. Cancer Res. (1990) [Pubmed]
  9. Stimulation of natural killer and antibody-dependent cellular cytotoxicity activities in mouse leukocytes by bombesin, gastrin-releasing peptide and neuromedin C: involvement of cyclic AMP, inositol 1,4,5-trisphosphate and protein kinase C. De la Fuente, M., Del Rio, M., Hernanz, A. J. Neuroimmunol. (1993) [Pubmed]
  10. Immunoreactive neuromedin B and neuromedin C: distribution and molecular heterogeneity in rat and human tissue extracts. Sakamoto, A., Kitamura, K., Haraguchi, Y., Yoshida, T., Tanaka, K. Am. J. Gastroenterol. (1987) [Pubmed]
  11. Neuromedin C: a bombesin-like peptide identified in porcine spinal cord. Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  12. Distinct receptors mediate gastrin-releasing peptide and neuromedin beta-induced delay of gastric of liquids in rats. Varga, G., Liehr, R.M., Scarpignato, C., Coy, D.H. Eur. J. Pharmacol. (1995) [Pubmed]
  13. Modulation of phagocytic function in murine peritoneal macrophages by bombesin, gastrin-releasing peptide and neuromedin C. De la Fuente, M., Del Rio, M., Ferrandez, M.D., Hernanz, A. Immunology (1991) [Pubmed]
  14. Primary structure and tissue distribution of guinea pig gastrin-releasing peptide. Shaw, C., Thim, L., Conlon, J.M. J. Neurochem. (1987) [Pubmed]
  15. The neuropeptide, neuromedin C, activates a potassium current in mouse macrophages. Ichinose, M., Hara, N., Sawada, M., Maeno, T. FEBS Lett. (1992) [Pubmed]
  16. Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum. Hansen, L., Hartmann, B., Bisgaard, T., Mineo, H., Jørgensen, P.N., Holst, J.J. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  17. Expression and electrophysiological identification of the receptor for bombesin and gastrin-releasing peptide in Xenopus laevis oocytes injected with polyA+ RNA from rat brain. Meyerhof, W., Morley, S.D., Richter, D. FEBS Lett. (1988) [Pubmed]
  18. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. Wang, L.H., Battey, J.F., Wada, E., Lin, J.T., Mantey, S., Coy, D.H., Jensen, R.T. Biochem. J. (1992) [Pubmed]
  19. Different types of bombesin receptors on neurons in the dorsal raphe nucleus and the rostral hypothalamus in rat brain slices in vitro. Pinnock, R.D., Reynolds, T., Woodruff, G.N. Brain Res. (1994) [Pubmed]
  20. Structural identification, subcellular localization and secretion of bovine adrenomedullary neuromedin C [GRP-(18-27)]. Lemaire, S., Trifaró, J.M., Chouinard, L., Cecyre, D., Dessureault, J., Mercier, P., Dumont, M. Peptides (1989) [Pubmed]
  21. Effect of the bombesin receptor blockers [Leu13, psi CH2NH-Leu14]bombesin and N-pivaloyl GRP(20-25) alkylamide (L 686,095-001C002) on basal and neuromedin C-stimulated PRL and GH release in pituitary cell aggregates. Houben, H., Denef, C. Peptides (1991) [Pubmed]
  22. Stimulatory effects of bombesin-like peptides on hypothalamic arcuate neurons in rat brain slices. Lin, J.Y., Pan, J.T. Brain Res. Bull. (1994) [Pubmed]
  23. The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides. Cassano, G., Resta, N., Gasparre, G., Lippe, C., Guanti, G. Cancer Lett. (2001) [Pubmed]
  24. Bombesin-like peptides stimulate somatostatin release from rat fundic D cells in primary culture. Schaffer, K., Herrmuth, H., Mueller, J., Coy, D.H., Wong, H.C., Walsh, J.H., Classen, M., Schusdziarra, V., Schepp, W. Am. J. Physiol. (1997) [Pubmed]
  25. Comparison of the actions of bombesin, gastrin-releasing peptide-27, neuromedin B, and gastrin-releasing peptide-10 in causing release of gastrin and gastric inhibitory peptide in rats. Greeley, G.H., Spannagel, A., Hill, F.L., Thompson, J.C. Proc. Soc. Exp. Biol. Med. (1986) [Pubmed]
  26. Neuropeptide-induced cytosolic Ca2+ transients and phosphatidylinositol turnover in cultured human retinal pigment epithelial cells. Kuriyama, S., Yoshimura, N., Ohuchi, T., Tanihara, H., Ito, S., Honda, Y. Brain Res. (1992) [Pubmed]
  27. Gastrin-releasing peptide (GRP) immunoreactivity in the rat retina: a radioimmunoassay, immunohistochemical and chromatographic study. McKillop, J.M., Foy, W.L., Johnston, C.F., Shaw, C., Murphy, R.F., Buchanan, K.D. Brain Res. (1988) [Pubmed]
  28. Involvement of cholinergic processes in cholecystokinin (CCK) release [corrected] by luminal oleic acid. Miyasaka, K., Kanai, S., Masuda, M., Ibuka, T., Nakai, K., Fujii, N., Funakoshi, A. J. Auton. Nerv. Syst. (1997) [Pubmed]
  29. Characterization and distribution of bombesin-like peptides in the rat brain and gastrointestinal tract. Hernanz, A. Biochem. Cell Biol. (1990) [Pubmed]
  30. Neurohormonal regulation of pancreatic exocrine function in rats without gene expression of the cholecystokinin-A receptor. Miyasaka, K., Masuda, M., Kawanami, T., Funakoshi, A. Pancreas (1996) [Pubmed]
  31. Mechanisms of stimulatory effect of neuromedin C on pancreatic exocrine secretion in conscious rats. Okubo, K., Miyasaka, K., Matsumoto, M., Funakoshi, A. Pancreas (1994) [Pubmed]
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