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Chemical Compound Review

Tyrphostin-25     2-[(3,4,5-trihydroxyphenyl) methylidene]pro...

Synonyms: Tyrphostin 25, Tyrphostin A25, Lopac-T-7290, CHEMBL310798, AG-J-10591, ...
 
 
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Disease relevance of NSC676484

 

High impact information on NSC676484

  • A stimulatory peptide derived from the NH2 terminus of the small GTP-binding protein ADP ribosylation factor 1 (ARF1) antagonized the inhibitory effect of TA25, indicating that both agents influence the same pathway leading to secretory vesicle formation [3].
  • This effect was abrogated by wortmannin and tyrphostin A25, indicating the potential involvement of phosphatidylinositol 3-kinase and epidermal growth factor (EGF) receptor activation [4].
  • Pretreatment of neutrophils either with Ro 31-8220 and H7, 2 specific inhibitors of protein kinase C (PKC), or with inhibitors of protein tyrosine kinases such as tyrphostin A25 or herbimycin A did not prevent the NSAID-mediated L-selectin shedding [5].
  • Tyrosine kinase inhibitors lavendustin A (1 mumol/L) and tyrphostin A25 (3 mumol/L) and protein kinase C inhibitors staurosporine (30 nmol/L) and chelerythrine (1 mumol/L) prevented the stretch-induced increase in right atrial ir-BNP concentrations at 2 hours [6].
  • We show that selective inhibition of PTK activity, with genistein and (3,4,5-tri-hydroxyphenyl)-methylene(-propanedinitrile) tyrphostin-25 inhibits basal and neuropeptide-stimulated SCLC cell growth [7].
 

Biological context of NSC676484

 

Anatomical context of NSC676484

 

Associations of NSC676484 with other chemical compounds

 

Gene context of NSC676484

 

Analytical, diagnostic and therapeutic context of NSC676484

References

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