Gene Review:
KLF10 - Kruppel-like factor 10
Homo sapiens
Synonyms:
EGR-alpha, EGRA, Krueppel-like factor 10, TGFB-inducible early growth response protein 1, TIEG, ...
- Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. Hefferan, T.E., Reinholz, G.G., Rickard, D.J., Johnsen, S.A., Waters, K.M., Subramaniam, M., Spelsberg, T.C. J. Biol. Chem. (2000)
- Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene. Subramaniam, M., Hefferan, T.E., Tau, K., Peus, D., Pittelkow, M., Jalal, S., Riggs, B.L., Roche, P., Spelsberg, T.C. J. Cell. Biochem. (1998)
- Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer. Antonello, D., Moore, P.S., Zamboni, G., Falconi, M., Scarpa, A. Cancer Lett. (2002)
- Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. Tachibana, I., Imoto, M., Adjei, P.N., Gores, G.J., Subramaniam, M., Spelsberg, T.C., Urrutia, R. J. Clin. Invest. (1997)
- Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. Kokkinakis, D.M., Liu, X., Chada, S., Ahmed, M.M., Shareef, M.M., Singha, U.K., Yang, S., Luo, J. Cancer Res. (2004)
- The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress. Ribeiro, A., Bronk, S.F., Roberts, P.J., Urrutia, R., Gores, G.J. Hepatology (1999)
- Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. Cook, T., Gebelein, B., Mesa, K., Mladek, A., Urrutia, R. J. Biol. Chem. (1998)
- The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. Noti, J.D., Johnson, A.K., Dillon, J.D. J. Biol. Chem. (2004)
- Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Subramaniam, M., Harris, S.A., Oursler, M.J., Rasmussen, K., Riggs, B.L., Spelsberg, T.C. Nucleic Acids Res. (1995)
- Direct action of naturally occurring estrogen metabolites on human osteoblastic cells. Robinson, J.A., Waters, K.M., Turner, R.T., Spelsberg, T.C. J. Bone Miner. Res. (2000)
- Nitric oxide-mediated upregulation of the TGF-beta-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-beta. Mitsumoto, M., Mitsumoto, A., Demple, B. Free Radic. Biol. Med. (2003)
- Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblasts. Tau, K.R., Hefferan, T.E., Waters, K.M., Robinson, J.A., Subramaniam, M., Riggs, B.L., Spelsberg, T.C. Endocrinology (1998)
- Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction. Partin, J.V., Anglin, I.E., Kyprianou, N. Br. J. Cancer (2003)
- Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. Johnsen, S.A., Subramaniam, M., Monroe, D.G., Janknecht, R., Spelsberg, T.C. J. Biol. Chem. (2002)
- TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Johnsen, S.A., Subramaniam, M., Janknecht, R., Spelsberg, T.C. Oncogene (2002)
- Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2. Wahab, N.A., Weston, B.S., Mason, R.M. Exp. Cell Res. (2005)
- Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. Reinholz, M.M., An, M.W., Johnsen, S.A., Subramaniam, M., Suman, V.J., Ingle, J.N., Roche, P.C., Spelsberg, T.C. Breast Cancer Res. Treat. (2004)