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Gene Review

Zfp36  -  zinc finger protein 36

Rattus norvegicus

Synonyms: Protein TIS11A, TIS11, TTP, Tis11a, Tristetraprolin, ...
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Disease relevance of Zfp36


High impact information on Zfp36

  • In contrast, these receptors retained the ability to mediate NGF-promoted survival and TIS8 and TIS11 immediate-early gene induction [5].
  • The effects of the purines, adenosine 5'-triphosphate (ATP) and guanosine 5'-triphosphate (GTP), and the pyrimidines, uridine 5'-triphosphate (UTP), cytidine 5'-triphosphate (CTP), and thymidine 5'-triphosphate (TTP), on vascular resistance were investigated in the rat mesenteric arterial bed [6].
  • In raised-tone preparations, vasodilator responses to ATP, UTP, TTP, and GTP were abolished after removal of the endothelium with sodium deoxycholate [6].
  • When tone was raised with norepinephrine (30 microM), these agents caused dose-related vasodilatation with the potency order of UTP = ATP greater than TTP = GTP [6].
  • In preparations at basal tone, these agents produced dose-related vasoconstriction with a potency order of ATP greater than CTP greater than UTP much greater than TTP = GTP [6].

Biological context of Zfp36


Anatomical context of Zfp36

  • TIS11, a member of the CCCH zinc finger protein family, was found to be distributed throughout cells with a preferential cytoplasmic localization when transiently expressed in COS-7 cells [7].
  • We showed the TIS11-positive particles to be stress granules (SGs), which are known to be formed in the cytoplasm of eukaryotic cells in response to environmental stresses [7].
  • The identified nuclear protein components may act as the positive trans-acting factors in the basal expression of the TIS11 gene in PC12 cells [9].
  • Database searches have revealed no similarities between cMG1 and other genes, except that over a 67-amino acid region the cMG1 protein shows 72% identity to the product of the TIS11 gene, a TPA-induced sequence in Swiss 3T3 cells [10].
  • The potency of nucleotides to raise [Ca2+]i was ATP gamma S > or = UDP > or = ATP approximately UDP approximately TTP, indicating that P2u receptors were expressed in the rat basilar smooth muscle cells [11].

Associations of Zfp36 with chemical compounds


Other interactions of Zfp36

  • The time course of the induction of NGFI-A, NGFI-B, fra-2 and TIS11 was similar to that previously observed with c-fos and the members of the jun family [12].
  • Galanin was found to induce c-fos, junB, and Tis11 mRNA in cultured astrocytes, providing evidence for the presence of functional galanin receptors on neuroglial cells [13].
  • RNAs from several brain regions were analyzed by Northern blot hybridization for their relative concentrations of nine IEG mRNAs (c-fos, c-jun, junB, TIS 1 (nur77), TIS7, TIS8 (zif268), TIS10, TIS11, and TIS21) [14].

Analytical, diagnostic and therapeutic context of Zfp36


  1. Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters. Kaneda, N., Oshima, M., Chung, S.Y., Guroff, G. Gene (1992) [Pubmed]
  2. Characterization of the 5'-flanking region of the rat TIS11 gene. Murata, T., Niimi, Y., Kaneda, N. Mol. Cell. Biochem. (2000) [Pubmed]
  3. An investigation into the mechanism of co-carcinogenesis of dietary cholesterol during the induction of colon cancer in rats by 1,2 dimethylhydrazine. Cruse, J.P., Lewin, M.R., Clark, C.G. Clinical oncology. (1984) [Pubmed]
  4. Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. McKee, E.E., Bentley, A.T., Hatch, M., Gingerich, J., Susan-Resiga, D. Cardiovasc. Toxicol. (2004) [Pubmed]
  5. Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis. Peng, X., Greene, L.A., Kaplan, D.R., Stephens, R.M. Neuron (1995) [Pubmed]
  6. Effects of purines and pyrimidines on the rat mesenteric arterial bed. Ralevic, V., Burnstock, G. Circ. Res. (1991) [Pubmed]
  7. Recruitment of mRNA-destabilizing protein TIS11 to stress granules is mediated by its zinc finger domain. Murata, T., Morita, N., Hikita, K., Kiuchi, K., Kiuchi, K., Kaneda, N. Exp. Cell Res. (2005) [Pubmed]
  8. Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11. Murata, T., Yoshino, Y., Morita, N., Kaneda, N. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. Cloning and characterization of the rat TIS11 gene. Kaneda, N., Murata, T., Niimi, Y., Minamiyama, M. Mol. Cell. Biochem. (2000) [Pubmed]
  10. The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes. Gomperts, M., Pascall, J.C., Brown, K.D. Oncogene (1990) [Pubmed]
  11. Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells. Sima, B., Weir, B.K., Macdonald, R.L., Zhang, H. Stroke (1997) [Pubmed]
  12. Induction of multiple immediate early genes in rat hypothalamic paraventricular nucleus after stress. Honkaniemi, J., Kononen, J., Kainu, T., Pyykönen, I., Pelto-Huikko, M. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  13. Cultured astrocytes express functional receptors for galanin. Priller, J., Haas, C.A., Reddington, M., Kreutzberg, G.W. Glia (1998) [Pubmed]
  14. Immediate early gene induction after neonatal hypoxia-ischemia. Gubits, R.M., Burke, R.E., Casey-McIntosh, G., Bandele, A., Munell, F. Brain Res. Mol. Brain Res. (1993) [Pubmed]
  15. Differential expression of immediate early genes after transection of the facial nerve. Haas, C.A., Donath, C., Kreutzberg, G.W. Neuroscience (1993) [Pubmed]
  16. Stimulation of P2Y-purinoceptors on astrocytes results in immediate early gene expression and potentiation of neuropeptide action. Priller, J., Reddington, M., Haas, C.A., Kreutzberg, G.W. Neuroscience (1998) [Pubmed]
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