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Gene Review

PTP4A2  -  protein tyrosine phosphatase type IVA,...

Homo sapiens

Synonyms: BM-008, HH13, HH7-2, HU-PP-1, OV-1, ...
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Disease relevance of PTP4A2


High impact information on PTP4A2

  • Cytokeratin 18 and 19 coexpression was, however, observed all along the maturation process together with oval cell-specific markers (M2-PK, OV-1, OV-6, and CD34); kinetics and expression profiles were dependent on the cell population [6].
  • The potency of GF120918 is assessed by dose-dependent sensitization of CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine respectively: GF120918 fully reverses multidrug resistance at 0.05 to 0.1 microM and is half maximally active at 0.02 microM [7].
  • Molecular modeling of the highly homologous PRL-1 and PRL-2 phosphatases revealed unique surface elements that are potentially important for specificity [8].
  • Expression of PRL-2 alone inhibited the endogenous alpha/betaGGT II activity in HeLa cells [9].
  • Additionally, PRL-2 prenylation is prequisite for betaGGT II binding [9].

Chemical compound and disease context of PTP4A2


Biological context of PTP4A2


Anatomical context of PTP4A2

  • Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells [14].
  • As prenylated PRL-2 is localized to the early endosome, we propose that this is where the interaction occurs [9].
  • Among the clones identified, cDNA OV-1 corresponds to a human homologue of a rat PRL-1 tyrosine phosphatase gene that shows enhanced expression during hepatic regeneration and in some tumour cell lines [12].
  • We show that PTPCAAX2 expression is up-regulated 4-fold in benign prostatic fibroblast cells 24 h after stimulation with LNCaP conditioned media and up-regulated 9-fold in prostatic tumour fibroblast cells [2].
  • However, many of the neural crest-derived trigeminal ganglia cells in the branchial arch localized to the non-neural crest core of the arch from HH13 and older donors [15].

Associations of PTP4A2 with chemical compounds

  • Neither the OV-1 nor the PRL-1 protein shares strong homology with any previously characterised phosphotyrosine phosphatase, suggesting that they probably belong to a new phosphatase family [12].
  • The drugs are converted to their methyl derivatives by a modification of the procedure of Greeley [Clin. Chem. 20, 192 (1974)] and then analyzed on a column containing 3% OV-1, with a temperature program, and detected by a nitrogen-selective detector [16].
  • Gas-chromatographic retention indices are given, in terms of methylene units, for 155 metabolically important compounds (mostly organic acids) as trimethylsilyl derivatives on 10% OV-1 and 10% OV-17 columns [17].
  • All the cell lines were radiation sensitive and also relatively sensitive to cisplatin; however, OV1P was the most resistant being consistent with its heterozygous P53 status [18].
  • Each component demonstrated a method detection limit (MDL) in the low-to sub-ppm range (benzene 10 mg x L(-1), n-hexane 0.54 mg x L(-1)) for light coatings of a commercially available poly-(dimethylsiloxane) gum (OV-1, > 10(6) g x mol(-1)) and lower MDLs for heavier coatings [19].

Other interactions of PTP4A2

  • Several of the differentially expressed genes may play a role in the pathogenesis of cHL because they represent potential oncogenes, such as rhoC, L-myc, and PTP4A, or transcription factors, such as ATF-5, ATBF1, and p21SNFT [20].

Analytical, diagnostic and therapeutic context of PTP4A2

  • The retention times on capillary gas-liquid chromatography (GLC) responded dramatically to the minor structural differences, and almost complete separation of the positional and stereochemical isomers was achieved by the combined use of SP-2340 and OV-17 (or OV-1) capillary columns [21].
  • After brief incubation and centrifugation, an aliquot of the supernate is injected directly onto the 3% OV-1 column [22].
  • Each of these steryl ester types can then be resubmitted to reversed-phase HPLC or analysed by GC-MS on a short fused-silica capillary column with a bonded phase of the OV-1 type [23].
  • METHODS AND RESULTS: Hepatoblastomas of various subtypes were investigated by electron microscopy, and by immunohistochemistry with the monoclonal antibodies OV-1 and OV-6, which recognize antigens associated with oval cells [24].
  • The separation was carried out on an OV-1 quartz capillary column, 15 m x 0.32 mm (0.52 microm), with high-purity nitrogen as carrier gas and flame ionization detector (FID) as detector [25].


  1. Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. Radke, I., Götte, M., Kersting, C., Mattsson, B., Kiesel, L., Wülfing, P. Br. J. Cancer (2006) [Pubmed]
  2. Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene. Wang, Q., Holmes, D.I., Powell, S.M., Lu, Q.L., Waxman, J. Cancer Lett. (2002) [Pubmed]
  3. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Pathak, M.K., Dhawan, D., Lindner, D.J., Borden, E.C., Farver, C., Yi, T. Mol. Cancer Ther. (2002) [Pubmed]
  4. Molecular characterization of a parasite antigen in sera from onchocerciasis patients that is immunologically cross-reactive with human keratin. Chandrashekar, R., Curtis, K.C., Weil, G.J. J. Infect. Dis. (1995) [Pubmed]
  5. Nuclear texture and chromatin structure in OV1/VCR human multidrug-resistant cell line. Yatouji, S., Trussardi-Regnier, A., Trentesaux, C., Liautaud-Roger, F., Dufer, J. Int. J. Oncol. (2003) [Pubmed]
  6. Origin and characterization of a human bipotent liver progenitor cell line. Parent, R., Marion, M.J., Furio, L., Trépo, C., Petit, M.A. Gastroenterology (2004) [Pubmed]
  7. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Hyafil, F., Vergely, C., Du Vignaud, P., Grand-Perret, T. Cancer Res. (1993) [Pubmed]
  8. Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. Kozlov, G., Cheng, J., Ziomek, E., Banville, D., Gehring, K., Ekiel, I. J. Biol. Chem. (2004) [Pubmed]
  9. Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. Si, X., Zeng, Q., Ng, C.H., Hong, W., Pallen, C.J. J. Biol. Chem. (2001) [Pubmed]
  10. Detection of a 45-kilodalton antigen overexpressed in a cisplatin-resistant human ovarian carcinoma cell line. Voeltzel, T., Lavaissiere, L., Ghillani, P., Benard, J., Bohuon, C., Bidart, J.M. Hybridoma (1994) [Pubmed]
  11. Cellular Localization of PRL-1 and PRL-2 Gene Expression in Normal Adult Human Tissues. Dumaual, C.M., Sandusky, G.E., Crowell, P.L., Randall, S.K. J. Histochem. Cytochem. (2006) [Pubmed]
  12. A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase. Montagna, M., Serova, O., Sylla, B.S., Feunteun, J., Lenoir, G.M. Hum. Genet. (1995) [Pubmed]
  13. Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. Zhao, Z., Lee, C.C., Monckton, D.G., Yazdani, A., Coolbaugh, M.I., Li, X., Bailey, J., Shen, Y., Caskey, C.T. Genomics (1996) [Pubmed]
  14. Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases. Werner, S.R., Lee, P.A., DeCamp, M.W., Crowell, D.N., Randall, S.K., Crowell, P.L. Cancer Lett. (2003) [Pubmed]
  15. Temporal restriction of migratory and lineage potential in rhombomere 1 and 2 neural crest. McKeown, S.J., Newgreen, D.F., Farlie, P.G. Dev. Biol. (2003) [Pubmed]
  16. Ultramicro gas-chromatographic analysis for anticonvulsants, with use of a nitrogen-selective detector. Vandemark, F.L., Adams, R.F. Clin. Chem. (1976) [Pubmed]
  17. Gas-chromatographic method of analysis for urinary organic acids. I. Retention indices of 155 metabolically important compounds. Tanaka, K., Hine, D.G., West-Dull, A., Lynn, T.B. Clin. Chem. (1980) [Pubmed]
  18. Characterisation of the p53 status, BCL-2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines. Pestell, K.E., Medlow, C.J., Titley, J.C., Kelland, L.R., Walton, M.I. Int. J. Cancer (1998) [Pubmed]
  19. Field screening of waterborne petroleum hydrocarbons by thickness shear-mode resonator measurements. Applebee, M.S., Geissler, J.D., Schellinger, A.P., Jaeger, R.J., Pierce, D.T. Environ. Sci. Technol. (2004) [Pubmed]
  20. Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes. Schwering, I., Bräuninger, A., Distler, V., Jesdinsky, J., Diehl, V., Hansmann, M.L., Rajewsky, K., Küppers, R. Mol. Med. (2003) [Pubmed]
  21. Separation of mono-, di-, and trihydroxy stereoisomers of bile acids by capillary gas-liquid chromatography. Iida, T., Chang, F.C., Matsumoto, T., Tamura, T. J. Lipid Res. (1983) [Pubmed]
  22. Rapid GLC determination of therapeutic plasma glycerin levels. Goehl, T.J., Pitlick, W.H., Shiu, G.K., Pirakitikulr, P. Journal of pharmaceutical sciences. (1977) [Pubmed]
  23. Strategy for the analysis of steryl esters from plant and animal tissues. Evershed, R.P., Male, V.L., Goad, L.J. J. Chromatogr. (1987) [Pubmed]
  24. Hepatic stem-like cells in hepatoblastoma: expression of cytokeratin 7, albumin and oval cell associated antigens detected by OV-1 and OV-6. Ruck, P., Xiao, J.C., Pietsch, T., Von Schweinitz, D., Kaiserling, E. Histopathology (1997) [Pubmed]
  25. Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Li, A.Q., Zhao, X.L. Biomed. Chromatogr. (2001) [Pubmed]
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