Gene Review:
Alox15 - arachidonate 15-lipoxygenase
Rattus norvegicus
Synonyms:
12-LOX, 12/15-lipoxygenase, 15-LOX, Alox12, Alox12l, ...
- Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Tang, D.G., Chen, Y.Q., Honn, K.V. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. Canals, S., Casarejos, M.J., de Bernardo, S., Rodríguez-Martín, E., Mena, M.A. J. Biol. Chem. (2003)
- Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. Zhang, Y., Wang, H., Li, J., Jimenez, D.A., Levitan, E.S., Aizenman, E., Rosenberg, P.A. J. Neurosci. (2004)
- 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Wang, H., Li, J., Follett, P.L., Zhang, Y., Cotanche, D.A., Jensen, F.E., Volpe, J.J., Rosenberg, P.A. Eur. J. Neurosci. (2004)
- A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Li, Y., Maher, P., Schubert, D. Neuron (1997)
- Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression. Pidgeon, G.P., Tang, K., Rice, R.L., Zacharek, A., Li, L., Taylor, J.D., Honn, K.V. Int. J. Cancer (2003)
- Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation. Song, Y., Wei, E.Q., Zhang, W.P., Ge, Q.F., Liu, J.R., Wang, M.L., Huang, X.J., Hu, X., Chen, Z. Brain Res. (2006)
- Renal oxygenases: differential contribution to vasoconstriction induced by ET-1 and ANG II. Oyekan, A., Balazy, M., McGiff, J.C. Am. J. Physiol. (1997)
- Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland. Zhang, H., Akbar, M., Kim, H.Y. Biochem. J. (1999)
- The erythroid arachidonate 15-lipoxygenase in rat reticulocytes. Schewe, T., Kroschwald, P., Kroschwald, A., Ludwig, P., Kühn, H. Biomed. Biochim. Acta (1990)
- Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. Kim, H.S., Ishizuka, M., Kazusaka, A., Fujita, S. J. Vet. Med. Sci. (2004)
- Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells. Tang, H.B., Inoue, A., Oshita, K., Hirate, K., Nakata, Y. Neuropharmacology (2005)
- Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung. Nagase, T., Fukuchi, Y., Jo, C., Teramoto, S., Uejima, Y., Ishida, K., Shimizu, T., Orimo, H. Biochem. Biophys. Res. Commun. (1990)
- The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury. Matsuyama, M., Nakatani, T., Hase, T., Kawahito, Y., Sano, H., Kawamura, M., Yoshimura, R. Transplant. Proc. (2004)