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Pla2g4a  -  phospholipase A2, group IVA (cytosolic,...

Rattus norvegicus

Synonyms: Cpla2, Cytosolic phospholipase A2, Phospholipase A2 group IVA, Pla2c, Pla2g4, ...
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Disease relevance of Pla2g4a


Psychiatry related information on Pla2g4a

  • These results indicate that the effect of lithium selectively involves the cPLA2/COX-2 pathway, which might be responsible for the therapeutic effect in bipolar disorder [6].

High impact information on Pla2g4a


Chemical compound and disease context of Pla2g4a


Biological context of Pla2g4a


Anatomical context of Pla2g4a


Associations of Pla2g4a with chemical compounds


Physical interactions of Pla2g4a


Regulatory relationships of Pla2g4a


Other interactions of Pla2g4a

  • The role of p42 MAPK in cPLA2 activation becomes redundant in the presence of relatively potent PKC activation [18].
  • Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease [27].
  • These proteins were identified as p42/p44 mitogen-activated protein (MAP) kinases by anti-MAP kinase immunoblots, which were known to activate cytosolic phospholipase A2 (cPLA2), a key enzyme in AA release [28].
  • These results suggest that HGF as well as EGF causes AA release, probably through activation of cPLA2 mediated by MAP kinases, and that PGs, metabolites of AA, might play a pivotal role in hepatocyte proliferation in an autocrine mechanism [28].
  • We examined the effects of IL-1beta on PGE2 production and changes in the relevant enzyme activities, and found that the activities of cytosolic phospholipase A2 (cPLA2), type II secretory PLA2 (sPLA2) and cyclooxygenase (COX)-2 in the day 21 cells were increased [29].

Analytical, diagnostic and therapeutic context of Pla2g4a


  1. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Haneda, M., Araki, S., Togawa, M., Sugimoto, T., Isono, M., Kikkawa, R. Diabetes (1997) [Pubmed]
  2. Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. Shi, Y., Cui, L., Dai, G., Chen, J., Pan, H., Song, L., Cheng, S., Wang, X. Prostaglandins Leukot. Essent. Fatty Acids (2006) [Pubmed]
  3. BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. Hsieh, H.L., Wu, C.Y., Hwang, T.L., Yen, M.H., Parker, P., Yang, C.M. J. Cell. Physiol. (2006) [Pubmed]
  4. Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia. Owada, Y., Tominaga, T., Yoshimoto, T., Kondo, H. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  5. Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors. Mangat, H., Peterson, L.N., Burns, K.D. J. Clin. Invest. (1997) [Pubmed]
  6. The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways. Weerasinghe, G.R., Rapoport, S.I., Bosetti, F. Brain Res. Bull. (2004) [Pubmed]
  7. Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. Gronich, J., Konieczkowski, M., Gelb, M.H., Nemenoff, R.A., Sedor, J.R. J. Clin. Invest. (1994) [Pubmed]
  8. Inhibition of cytoplasmic phospholipase A2 expression by glucocorticoids in rat intestinal epithelial cells. Dolan-O'keefe, M., Nick, H.S. Gastroenterology (1999) [Pubmed]
  9. Activation of cPLA2, PKC, and ERKs in the rat cerebral cortex during ischemia/reperfusion. Saluja, I., O'Regan, M.H., Song, D., Phillis, J.W. Neurochem. Res. (1999) [Pubmed]
  10. A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions. Sandhya, T.L., Ong, W.Y., Horrocks, L.A., Farooqui, A.A. Brain Res. (1998) [Pubmed]
  11. Interleukin-1 beta induces cytosolic phospholipase A2 gene in rats C6 glioma cell line. Ozaki, M., Morii, H., Qvist, R., Watanabe, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. Slomiany, B.L., Slomiany, A. IUBMB Life (2006) [Pubmed]
  13. ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors. Chen, W.C., Chen, C.C. Glia (1998) [Pubmed]
  14. 1alpha,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: activation of cytosolic PLA2. Gentili, C., Morelli, S., de Boland, A.R. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  15. STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. Dronadula, N., Liu, Z., Wang, C., Cao, H., Rao, G.N. J. Biol. Chem. (2005) [Pubmed]
  16. Signal pathways mediating oxytocin stimulation of prostaglandin synthesis in select target cells. Soloff, M.S., Jeng, Y.J., Copland, J.A., Strakova, Z., Hoare, S. Exp. Physiol. (2000) [Pubmed]
  17. Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. Kuwata, H., Nakatani, Y., Murakami, M., Kudo, I. J. Biol. Chem. (1998) [Pubmed]
  18. Complement activates phospholipases and protein kinases in glomerular epithelial cells. Cybulsky, A.V., Papillon, J., McTavish, A.J. Kidney Int. (1998) [Pubmed]
  19. Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Hsu, M.F., Lu, M.C., Tsao, L.T., Kuan, Y.H., Chen, C.C., Wang, J.P. Biochem. Pharmacol. (2004) [Pubmed]
  20. Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury. Birnbaum, Y., Ye, Y., Rosanio, S., Tavackoli, S., Hu, Z.Y., Schwarz, E.R., Uretsky, B.F. Cardiovasc. Res. (2005) [Pubmed]
  21. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. Lankisch, T.O., Nozu, F., Owyang, C., Tsunoda, Y. Eur. J. Cell Biol. (1999) [Pubmed]
  22. Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase). Tournier, C., Thomas, G., Pierre, J., Jacquemin, C., Pierre, M., Saunier, B. Eur. J. Biochem. (1997) [Pubmed]
  23. Tumor necrosis factor-alpha and ceramide induce cell death through different mechanisms in rat mesangial cells. Guo, Y.L., Kang, B., Yang, L.J., Williamson, J.R. Am. J. Physiol. (1999) [Pubmed]
  24. Alterations of activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl)phthalate-induced testicular atrophy. Kim, H.S., Ishizuka, M., Kazusaka, A., Fujita, S. J. Vet. Med. Sci. (2004) [Pubmed]
  25. On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. Sakanaka, C., Ferby, I., Waga, I., Bito, H., Shimizu, T. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  26. Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3. Chang, E.Y., Szallasi, Z., Acs, P., Raizada, V., Wolfe, P.C., Fewtrell, C., Blumberg, P.M., Rivera, J. J. Immunol. (1997) [Pubmed]
  27. Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease. Aukema, H.M., Adolphe, J., Mishra, S., Jiang, J., Cuozzo, F.P., Ogborn, M.R. FASEB J. (2003) [Pubmed]
  28. Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation. Adachi, T., Nakashima, S., Saji, S., Nakamura, T., Nozawa, Y. Hepatology (1995) [Pubmed]
  29. Augmented prostaglandin E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1 beta-stimulated rat calvarial cells during the mineralizing phase. Higashi, S., Ohishi, H., Kudo, I. Inflamm. Res. (2000) [Pubmed]
  30. Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. LaPointe, M.C., Isenović, E. Hypertension (1999) [Pubmed]
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