Gene Review:
EP300 - E1A binding protein p300
Homo sapiens
Synonyms:
E1A-associated protein p300, Histone acetyltransferase p300, KAT3B, P300, RSTS2, ...
- Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Roelfsema, J.H., White, S.J., Ariyürek, Y., Bartholdi, D., Niedrist, D., Papadia, F., Bacino, C.A., den Dunnen, J.T., van Ommen, G.J., Breuning, M.H., Hennekam, R.C., Peters, D.J. Am. J. Hum. Genet. (2005)
- No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. Campbell, I.G., Choong, D., Chenevix-Trench, G. Breast Cancer Res. (2004)
- More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Steensma, D.P., Pardanani, A., Stevenson, W.S., Hoyt, R., Kiu, H., Grigg, A.P., Szer, J., Juneja, S., Hilton, D.J., Alexander, W.S., Roberts, A.W. Blood (2006)
- The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. Kimbrel, E.A., Kung, A.L. J. Biol. Chem. (2009)
- A metric for thought: a comparison of P300 latency and reaction time. McCarthy, G., Donchin, E. Science (1981)
- Visual event-related P300 potentials in early portosystemic encephalopathy. Kügler, C.F., Lotterer, E., Petter, J., Wensing, G., Taghavy, A., Hahn, E.G., Fleig, W.E. Gastroenterology (1992)
- Prefrontal dysfunction and treatment response in geriatric depression. Kalayam, B., Alexopoulos, G.S. Arch. Gen. Psychiatry (1999)
- Auditory P300 in borderline personality disorder and schizophrenia. Kutcher, S.P., Blackwood, D.H., St Clair, D., Gaskell, D.F., Muir, W.J. Arch. Gen. Psychiatry (1987)
- Mutations truncating the EP300 acetylase in human cancers. Gayther, S.A., Batley, S.J., Linger, L., Bannister, A., Thorpe, K., Chin, S.F., Daigo, Y., Russell, P., Wilson, A., Sowter, H.M., Delhanty, J.D., Ponder, B.A., Kouzarides, T., Caldas, C. Nat. Genet. (2000)
- Role of CBP/P300 in nuclear receptor signalling. Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Nature (1996)
- Task-relevant late positive component of the auditory event-related potential in monkeys resembles P300 in humans. Arthur, D.L., Starr, A. Science (1984)
- Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Kerr, D., Sherwin, R.S., Pavalkis, F., Fayad, P.B., Sikorski, L., Rife, F., Tamborlane, W.V., During, M.J. Ann. Intern. Med. (1993)
- Hypoglycemic thresholds for cognitive dysfunction in humans. Blackman, J.D., Towle, V.L., Lewis, G.F., Spire, J.P., Polonsky, K.S. Diabetes (1990)
- Stimulus novelty differentially affects attentional allocation in PTSD. Kimble, M., Kaloupek, D., Kaufman, M., Deldin, P. Biol. Psychiatry (2000)
- The effect of tetrahydroaminoacridine (THA) on P300 in Alzheimer's disease. van Gool, W.A., Waardenburg, J., Meyjes, F.E., Weinstein, H.C., de Wilde, A. Biol. Psychiatry (1991)
- Characterizing impaired functional alertness from diphenhydramine in the elderly with performance and neurophysiologic measures. McEvoy, L.K., Smith, M.E., Fordyce, M., Gevins, A. Sleep. (2006)
- Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines. Tillinghast, G.W., Partee, J., Albert, P., Kelley, J.M., Burtow, K.H., Kelly, K. Genes Chromosomes Cancer (2003)
- DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Bartsch, O., Schmidt, S., Richter, M., Morlot, S., Seemanová, E., Wiebe, G., Rasi, S. Hum. Genet. (2005)
- p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Iyer, N.G., Chin, S.F., Ozdag, H., Daigo, Y., Hu, D.E., Cariati, M., Brindle, K., Aparicio, S., Caldas, C. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Deng, L., de la Fuente, C., Fu, P., Wang, L., Donnelly, R., Wade, J.D., Lambert, P., Li, H., Lee, C.G., Kashanchi, F. Virology (2000)
- Mutation analysis of EP300 in colon, breast and ovarian carcinomas. Bryan, E.J., Jokubaitis, V.J., Chamberlain, N.L., Baxter, S.W., Dawson, E., Choong, D.Y., Campbell, I.G. Int. J. Cancer (2002)
- Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition. Krubasik, D., Iyer, N.G., English, W.R., Ahmed, A.A., Vias, M., Roskelley, C., Brenton, J.D., Caldas, C., Murphy, G. Br. J. Cancer (2006)
- First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe. Salisbury, D.F., Shenton, M.E., Sherwood, A.R., Fischer, I.A., Yurgelun-Todd, D.A., Tohen, M., McCarley, R.W. Arch. Gen. Psychiatry (1998)
- Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Ford, J.M., Gray, M., Whitfield, S.L., Turken, A.U., Glover, G., Faustman, W.O., Mathalon, D.H. Arch. Gen. Psychiatry (2004)
- Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. McManus, K.J., Hendzel, M.J. Mol. Cell. Biol. (2003)
- Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man. De Feo, P., Gallai, V., Mazzotta, G., Crispino, G., Torlone, E., Perriello, G., Ventura, M.M., Santeusanio, F., Brunetti, P., Bolli, G.B. J. Clin. Invest. (1988)
- Differential interactions of the CREB/ATF family of transcription factors with p300 and adenovirus E1A. Lee, J.S., Zhang, X., Shi, Y. J. Biol. Chem. (1996)
- Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators. Schroer, K., Zhu, Y., Saunders, M.A., Deng, W.G., Xu, X.M., Meyer-Kirchrath, J., Wu, K.K. Circulation (2002)
- c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells. Sankar, N., Kadeppagari, R.K., Thimmapaya, B. J. Biol. Chem. (2009)
- Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injury. Kassimatis, T.I., Giannopoulou, I., Koumoundourou, D., Theodorakopoulou, E., Varakis, I., Nakopoulou, L. J. Cell. Mol. Med. (2006)
- Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Lee, J.S., Galvin, K.M., See, R.H., Eckner, R., Livingston, D., Moran, E., Shi, Y. Genes Dev. (1995)
- P300 transcriptional repression is mediated by SUMO modification. Girdwood, D., Bumpass, D., Vaughan, O.A., Thain, A., Anderson, L.A., Snowden, A.W., Garcia-Wilson, E., Perkins, N.D., Hay, R.T. Mol. Cell (2003)
- MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Chaffanet, M., Gressin, L., Preudhomme, C., Soenen-Cornu, V., Birnbaum, D., Pébusque, M.J. Genes Chromosomes Cancer (2000)
- ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. Chen, Y.J., Wang, Y.N., Chang, W.C. J. Biol. Chem. (2007)
- Neuropsychological and event-related potential correlates of nonepileptic seizures. Drake, M.E., Huber, S.J., Pakalnis, A., Phillips, B.B. The Journal of neuropsychiatry and clinical neurosciences. (1993)