The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

EP300  -  E1A binding protein p300

Homo sapiens

Synonyms: E1A-associated protein p300, Histone acetyltransferase p300, KAT3B, P300, RSTS2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of EP300


Psychiatry related information on EP300

  • A metric for thought: a comparison of P300 latency and reaction time [5].
  • Abnormal P300 test results were also found in 78% of the clinically nonencephalopathic cirrhotics, while psychometric tests showed abnormalities in only 41% [6].
  • The psychomotor retardation item of the Hamilton Depression Rating Scale, the initiation/perseveration subscore of the Mattis Dementia Rating Scale, and the latency of the P300 auditory evoked potential were used as indices of prefrontal dysfunction [7].
  • Auditory P300 in borderline personality disorder and schizophrenia [8].
  • The patients with BPD were found to differ from patients with nonborderline personality disorders, having a longer P3 latency and smaller P3 amplitude [8].

High impact information on EP300

  • EP300 acetylation of TP53 in response to DNA damage regulates its DNA-binding and transcription functions [9].
  • The EP300 protein is a histone acetyltransferase that regulates transcription via chromatin remodelling and is important in the processes of cell proliferation and differentiation [9].
  • A role for EP300 in cancer has been implied by the fact that it is targeted by viral oncoproteins, it is fused to MLL in Leukaemia and two missense sequence alterations in EP300 were identified in epithelial malignancies [9].
  • Role of CBP/P300 in nuclear receptor signalling [10].
  • Task-relevant late positive component of the auditory event-related potential in monkeys resembles P300 in humans [11].

Chemical compound and disease context of EP300


Biological context of EP300


Anatomical context of EP300

  • Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines [17].
  • Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition [22].
  • This P300 asymmetry suggests left temporal lobe dysfunction at the onset of schizophrenia [23].
  • In healthy subjects, NoGo P300 was related to activations in the anterior cingulate cortex, dorsal lateral prefrontal cortex, and right inferior parietal lobule and caudate nucleus, perhaps reflecting conflict experienced when withholding a response, control needed to inhibit a response, and stopping a response in action, respectively [24].
  • MEASUREMENTS: Middle cerebral artery velocity (V MCA), counter-regulatory hormone levels, hypoglycemic symptoms, and cognitive function (P300 evoked potentials) [12].

Associations of EP300 with chemical compounds

  • When xenografted, p300(-) cells are more sensitive to chemotherapy with doxorubicin [19].
  • The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways [10].
  • The assay combines the spatial resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues [25].
  • In contrast, a greater decrement in plasma glucose concentration from 87 +/- 3 to 72 +/- 1 mg/dl for 120 min caused an increase in the latency of the P300 wave (from 301 +/- 12 to 348 +/- 20 ms, P less than 0.01), a subsequent increase in all counterregulatory hormones but no hypoglycemic symptoms [26].
  • Significant inverse correlations were found between the P300 latencies and measures of quantitative liver function such as galactose-elimination capacity and aminopyrine breath test [6].

Physical interactions of EP300

  • The adenovirus E1A-associated protein p300 is a transcriptional cofactor that interacts with YY1 and mediates the relief of YY1 transcriptional repression by E1A [27].
  • CREB-2 and ATF-2 bound to CRE serve as an anchor for P300 interaction with upstream transactivators and downstream transcription machinery [28].

Regulatory relationships of EP300


Other interactions of EP300


Analytical, diagnostic and therapeutic context of EP300


  1. Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Roelfsema, J.H., White, S.J., Ariyürek, Y., Bartholdi, D., Niedrist, D., Papadia, F., Bacino, C.A., den Dunnen, J.T., van Ommen, G.J., Breuning, M.H., Hennekam, R.C., Peters, D.J. Am. J. Hum. Genet. (2005) [Pubmed]
  2. No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. Campbell, I.G., Choong, D., Chenevix-Trench, G. Breast Cancer Res. (2004) [Pubmed]
  3. More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Steensma, D.P., Pardanani, A., Stevenson, W.S., Hoyt, R., Kiu, H., Grigg, A.P., Szer, J., Juneja, S., Hilton, D.J., Alexander, W.S., Roberts, A.W. Blood (2006) [Pubmed]
  4. The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. Kimbrel, E.A., Kung, A.L. J. Biol. Chem. (2009) [Pubmed]
  5. A metric for thought: a comparison of P300 latency and reaction time. McCarthy, G., Donchin, E. Science (1981) [Pubmed]
  6. Visual event-related P300 potentials in early portosystemic encephalopathy. Kügler, C.F., Lotterer, E., Petter, J., Wensing, G., Taghavy, A., Hahn, E.G., Fleig, W.E. Gastroenterology (1992) [Pubmed]
  7. Prefrontal dysfunction and treatment response in geriatric depression. Kalayam, B., Alexopoulos, G.S. Arch. Gen. Psychiatry (1999) [Pubmed]
  8. Auditory P300 in borderline personality disorder and schizophrenia. Kutcher, S.P., Blackwood, D.H., St Clair, D., Gaskell, D.F., Muir, W.J. Arch. Gen. Psychiatry (1987) [Pubmed]
  9. Mutations truncating the EP300 acetylase in human cancers. Gayther, S.A., Batley, S.J., Linger, L., Bannister, A., Thorpe, K., Chin, S.F., Daigo, Y., Russell, P., Wilson, A., Sowter, H.M., Delhanty, J.D., Ponder, B.A., Kouzarides, T., Caldas, C. Nat. Genet. (2000) [Pubmed]
  10. Role of CBP/P300 in nuclear receptor signalling. Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Nature (1996) [Pubmed]
  11. Task-relevant late positive component of the auditory event-related potential in monkeys resembles P300 in humans. Arthur, D.L., Starr, A. Science (1984) [Pubmed]
  12. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Kerr, D., Sherwin, R.S., Pavalkis, F., Fayad, P.B., Sikorski, L., Rife, F., Tamborlane, W.V., During, M.J. Ann. Intern. Med. (1993) [Pubmed]
  13. Hypoglycemic thresholds for cognitive dysfunction in humans. Blackman, J.D., Towle, V.L., Lewis, G.F., Spire, J.P., Polonsky, K.S. Diabetes (1990) [Pubmed]
  14. Stimulus novelty differentially affects attentional allocation in PTSD. Kimble, M., Kaloupek, D., Kaufman, M., Deldin, P. Biol. Psychiatry (2000) [Pubmed]
  15. The effect of tetrahydroaminoacridine (THA) on P300 in Alzheimer's disease. van Gool, W.A., Waardenburg, J., Meyjes, F.E., Weinstein, H.C., de Wilde, A. Biol. Psychiatry (1991) [Pubmed]
  16. Characterizing impaired functional alertness from diphenhydramine in the elderly with performance and neurophysiologic measures. McEvoy, L.K., Smith, M.E., Fordyce, M., Gevins, A. Sleep. (2006) [Pubmed]
  17. Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines. Tillinghast, G.W., Partee, J., Albert, P., Kelley, J.M., Burtow, K.H., Kelly, K. Genes Chromosomes Cancer (2003) [Pubmed]
  18. DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Bartsch, O., Schmidt, S., Richter, M., Morlot, S., Seemanová, E., Wiebe, G., Rasi, S. Hum. Genet. (2005) [Pubmed]
  19. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Iyer, N.G., Chin, S.F., Ozdag, H., Daigo, Y., Hu, D.E., Cariati, M., Brindle, K., Aparicio, S., Caldas, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Deng, L., de la Fuente, C., Fu, P., Wang, L., Donnelly, R., Wade, J.D., Lambert, P., Li, H., Lee, C.G., Kashanchi, F. Virology (2000) [Pubmed]
  21. Mutation analysis of EP300 in colon, breast and ovarian carcinomas. Bryan, E.J., Jokubaitis, V.J., Chamberlain, N.L., Baxter, S.W., Dawson, E., Choong, D.Y., Campbell, I.G. Int. J. Cancer (2002) [Pubmed]
  22. Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition. Krubasik, D., Iyer, N.G., English, W.R., Ahmed, A.A., Vias, M., Roskelley, C., Brenton, J.D., Caldas, C., Murphy, G. Br. J. Cancer (2006) [Pubmed]
  23. First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe. Salisbury, D.F., Shenton, M.E., Sherwood, A.R., Fischer, I.A., Yurgelun-Todd, D.A., Tohen, M., McCarley, R.W. Arch. Gen. Psychiatry (1998) [Pubmed]
  24. Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Ford, J.M., Gray, M., Whitfield, S.L., Turken, A.U., Glover, G., Faustman, W.O., Mathalon, D.H. Arch. Gen. Psychiatry (2004) [Pubmed]
  25. Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. McManus, K.J., Hendzel, M.J. Mol. Cell. Biol. (2003) [Pubmed]
  26. Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man. De Feo, P., Gallai, V., Mazzotta, G., Crispino, G., Torlone, E., Perriello, G., Ventura, M.M., Santeusanio, F., Brunetti, P., Bolli, G.B. J. Clin. Invest. (1988) [Pubmed]
  27. Differential interactions of the CREB/ATF family of transcription factors with p300 and adenovirus E1A. Lee, J.S., Zhang, X., Shi, Y. J. Biol. Chem. (1996) [Pubmed]
  28. Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators. Schroer, K., Zhu, Y., Saunders, M.A., Deng, W.G., Xu, X.M., Meyer-Kirchrath, J., Wu, K.K. Circulation (2002) [Pubmed]
  29. c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells. Sankar, N., Kadeppagari, R.K., Thimmapaya, B. J. Biol. Chem. (2009) [Pubmed]
  30. Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injury. Kassimatis, T.I., Giannopoulou, I., Koumoundourou, D., Theodorakopoulou, E., Varakis, I., Nakopoulou, L. J. Cell. Mol. Med. (2006) [Pubmed]
  31. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Lee, J.S., Galvin, K.M., See, R.H., Eckner, R., Livingston, D., Moran, E., Shi, Y. Genes Dev. (1995) [Pubmed]
  32. P300 transcriptional repression is mediated by SUMO modification. Girdwood, D., Bumpass, D., Vaughan, O.A., Thain, A., Anderson, L.A., Snowden, A.W., Garcia-Wilson, E., Perkins, N.D., Hay, R.T. Mol. Cell (2003) [Pubmed]
  33. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Chaffanet, M., Gressin, L., Preudhomme, C., Soenen-Cornu, V., Birnbaum, D., Pébusque, M.J. Genes Chromosomes Cancer (2000) [Pubmed]
  34. ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. Chen, Y.J., Wang, Y.N., Chang, W.C. J. Biol. Chem. (2007) [Pubmed]
  35. Neuropsychological and event-related potential correlates of nonepileptic seizures. Drake, M.E., Huber, S.J., Pakalnis, A., Phillips, B.B. The Journal of neuropsychiatry and clinical neurosciences. (1993) [Pubmed]
WikiGenes - Universities