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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Hypoxia

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Disease relevance of Cell Hypoxia


High impact information on Cell Hypoxia

  • Results of our studies on rat muscle, liver, heart, brain, and plasma suggest that there is no evidence of bioenergetic failure in these septic tissues and that the increase in lactate production is not necessarily due to cellular hypoxia [6].
  • Misonidazole binding in murine liver tissue: a marker for cellular hypoxia in vivo [7].
  • An increased apoptotic index of tumor cells in endostatin-treated tumors [3.2 +/- 0.5% versus 1.9 +/- 0.3% (P < 0.05)] was observed in conjunction with a significant decrease in tumor perfused vessels (DiOC7 staining), and an increase in tumor cell hypoxia (EF5 staining) [8].
  • S-Nitroso-N-acetyl-D, L-penicillamine (SNAP), a nitric oxide (NO) donor, and desferrioxamine (DFx) and cobalt chloride, mimics of cellular hypoxia, similarly stimulated VEGF mRNA expression and secretion [9].
  • Cellular hypoxia induced a time-dependent increase in nuclear p65, suggesting a dominant role for NF-kappaB in hypoxia-elicited induction of proinflammatory gene products [10].

Biological context of Cell Hypoxia


Anatomical context of Cell Hypoxia


Associations of Cell Hypoxia with chemical compounds

  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness [17].
  • Measurement of hypoxanthine/xanthine has been suggested to be a useful indicator of cellular hypoxia [18].
  • High speed epicardial fluorescence photography using reduced nicotinamide adenosine nucleotide (NADH) was used to identify areas of cell anoxia [19].
  • These findings are consistent with a role for E-4031-sensitive K+ current, and possibly HERG-like K+ currents, in the type I cell hypoxia response maturation [20].
  • The aim of this study was to compare tumor cell hypoxia assessed by the hypoxic cell marker pimonidazole (PIMO) with expression of the endogenous hypoxia-related marker carbonic anhydrase IX (CAIX) in three human head and neck tumor lines [21].

Gene context of Cell Hypoxia


  1. Adenine nucleotides, transport activity and hypoxic necrosis in the thick ascending limb of Henle. Shanley, P.F., Johnson, G.C. Kidney Int. (1989) [Pubmed]
  2. [3H]BHDP as a novel and selective ligand for sigma1 receptors in liver mitochondria and brain synaptosomes of the rat. Klouz, A., Tillement, J.P., Boussard, M.F., Wierzbicki, M., Berezowski, V., Cecchelli, R., Labidalle, S., Onténiente, B., Morin, D. FEBS Lett. (2003) [Pubmed]
  3. Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats. Levy, B., Mansart, A., Bollaert, P.E., Franck, P., Mallie, J.P. Intensive care medicine. (2003) [Pubmed]
  4. Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas. Okada, K., Osaki, M., Araki, K., Ishiguro, K., Ito, H., Ohgi, S. Anticancer Res. (2005) [Pubmed]
  5. Mitochondrial dysfunction in chronic ischemia and peripheral vascular disease. Kemp, G.J. Mitochondrion (2004) [Pubmed]
  6. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. Hotchkiss, R.S., Karl, I.E. JAMA (1992) [Pubmed]
  7. Misonidazole binding in murine liver tissue: a marker for cellular hypoxia in vivo. Maxwell, A.P., MacManus, M.P., Gardiner, T.A. Gastroenterology (1989) [Pubmed]
  8. Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas. Ding, I., Sun, J.Z., Fenton, B., Liu, W.M., Kimsely, P., Okunieff, P., Min, W. Cancer Res. (2001) [Pubmed]
  9. Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells. Ankoma-Sey, V., Wang, Y., Dai, Z. Hepatology (2000) [Pubmed]
  10. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. Taylor, C.T., Fueki, N., Agah, A., Hershberg, R.M., Colgan, S.P. J. Biol. Chem. (1999) [Pubmed]
  11. Acute hypoxia increases the aggressive characteristics and survival properties of prostate cancer cells. Ghafar, M.A., Anastasiadis, A.G., Chen, M.W., Burchardt, M., Olsson, L.E., Xie, H., Benson, M.C., Buttyan, R. Prostate (2003) [Pubmed]
  12. Brief hypoxic stress suppresses postbacteremic NF-kappaB activation and TNF-alpha bioactivity in perfused liver. Loftis, L.L., Johanns, C.A., Lechner, A.J., Matuschak, G.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000) [Pubmed]
  13. Effect of hypoxia on placental activin A, inhibin A and follistatin synthesis. Manuelpillai, U., Schneider-Kolsky, M., Thirunavukarasu, P., Dole, A., Waldron, K., Wallace, E.M. Placenta (2003) [Pubmed]
  14. Effects of hypoxia and glutathione depletion on hemoglobin- and myoglobin-mediated oxidative stress toward endothelium. D'Agnillo, F., Wood, F., Porras, C., Macdonald, V.W., Alayash, A.I. Biochim. Biophys. Acta (2000) [Pubmed]
  15. Parallel induction of epithelial surface-associated chemokine and proteoglycan by cellular hypoxia: implications for neutrophil activation. Furuta, G.T., Dzus, A.L., Taylor, C.T., Colgan, S.P. J. Leukoc. Biol. (2000) [Pubmed]
  16. Hypothetical roles of angiogenesis, osmotic swelling, and ischemia in high-altitude cerebral edema. Severinghaus, J.W. J. Appl. Physiol. (1995) [Pubmed]
  17. Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. Peeters, R.P., Wouters, P.J., Kaptein, E., van Toor, H., Visser, T.J., Van den Berghe, G. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  18. Cellular hypoxia during hemodialysis. Demonstration of intradialytic release of purine and pyrimidine metabolites. Knudsen, F., Thorgaard Andersen, P. Blood Purif. (1985) [Pubmed]
  19. Temporal relation between onset of cell anoxia and ischemic contractile failure. Myocardial ischemia and left ventricular failure in the isolated, perfused rabbit heart. Harden, W.R., Barlow, C.H., Simson, M.B., Harken, A.H. Am. J. Cardiol. (1979) [Pubmed]
  20. Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells. Kim, I., Boyle, K.M., Carroll, J.L. J. Appl. Physiol. (2005) [Pubmed]
  21. Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines. Troost, E.G., Bussink, J., Kaanders, J.H., van Eerd, J., Peters, J.P., Rijken, P.F., Boerman, O.C., van der Kogel, A.J. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  22. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Pan, Y., Oprysko, P.R., Asham, A.M., Koch, C.J., Simon, M.C. Oncogene (2004) [Pubmed]
  23. Mechanisms of hypoxic tolerance in presymptomatic APP23 transgenic mice. von Arnim, C.A., Verstege, E., Etrich, S.M., Riepe, M.W. Mech. Ageing Dev. (2006) [Pubmed]
  24. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Swinson, D.E., O'Byrne, K.J. Clinical lung cancer. (2006) [Pubmed]
  25. Regulation of hypoxia-inducible factor 1 in enterocytic cells. Bertges, D.J., Berg, S., Fink, M.P., Delude, R.L. J. Surg. Res. (2002) [Pubmed]
  26. Effects of prolonged tourniquet ischaemia and short-term venous stasis on plasma endothelin-1 levels in man. Metsärinne, K., Nordström, D., Santavirta, S., Kauste, A., Tikkanen, I., Fyhrquist, F. Scand. J. Clin. Lab. Invest. (1995) [Pubmed]
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