Disease relevance of Aspergillosis, Allergic Bronchopulmonary

• CONCLUSIONS: For patients with corticosteroid-dependent allergic bronchopulmonary aspergillosis, the addition of itraconazole can lead to improvement in the condition without added toxicity [1].
• Itraconazole and allergic bronchopulmonary aspergillosis in twin brothers with cystic fibrosis [2].
• A 42-year-old female patient with previously diagnosed seasonal allergic rhinitis, anaphylactic food sensitivity, and exertional asthma is described who developed concomitant allergic bronchopulmonary aspergillosis and allergic aspergillus sinusitis [3].
• We studied a 23-year-old patient of Chinese ethnicity with sweat chloride values of 104 mM/l, pancreatic sufficiency, an FEV1 60% of normal, sputum cultures positive for Staphylococcus aureus and Burkholderia cepacia, and a history of allergic bronchopulmonary aspergillosis [4].
• The study groups comprised patients of bronchial asthma with allergic rhinitis (n = 49) and allergic bronchopulmonary aspergillosis (APBA) (n = 11) and unrelated age-matched healthy controls of Indian origin (n = 84) [5].

High impact information on Aspergillosis, Allergic Bronchopulmonary

• A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis [1].
• Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis [6].
• Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis [7].
• Immunomodulatory role of C10 chemokine in a murine model of allergic bronchopulmonary aspergillosis [8].
• The immunomodulatory role of the chemokine C10 was explored in allergic airway responses during experimental allergic bronchopulmonary aspergillosis (ABPA) [8].

Chemical compound and disease context of Aspergillosis, Allergic Bronchopulmonary

• In persons with allergic bronchopulmonary aspergillosis, cutaneous responses to Aspergillus fumigatus allergen were compared with responses to other allergens and to anti-IgE; in relation to early wheal-and-flare responses, the corresponding LCAR induced by A. fumigatus were approximately the same size as those induced by the other reactants [9].
• Relationships between prednisone therapy, disease activity, and the total serum IgE level in allergic bronchopulmonary aspergillosis [10].
• Furthermore, both native and recombinant Asp f 2 exhibited specific immunoglobulin (IgE) binding with allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis-ABPA patients, whereas A. fumigatus-sensitized allergic asthma and normal control subjects failed to show IgE binding with Asp f 2 [11].
• Trial of ketoconazole in allergic bronchopulmonary aspergillosis [12].
• Long term prednisolone was given to 28 of the 33 patients with allergic bronchopulmonary aspergillosis (mean 7.4 mg/day for 11 years) and to 29 of the 32 "non-aspergillosis" patients (mean 8.1 mg/day for 4.6 years) [13].

Biological context of Aspergillosis, Allergic Bronchopulmonary

• Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA) [14].
• Interleukin-8 gene expression and protein release were increased in allergic bronchopulmonary aspergillosis and correlated with airway neutrophilia and airway obstruction [15].
• SNPs in SP-A2 and MBL genes showed significant associations with patients of allergic bronchopulmonary aspergillosis in an Indian population [16].

Anatomical context of Aspergillosis, Allergic Bronchopulmonary

• Conformational and linear B-cell epitopes of Asp f 2, a major allergen of Aspergillus fumigatus, bind differently to immunoglobulin E antibody in the sera of allergic bronchopulmonary aspergillosis patients [17].
• In 1983, Katzenstein, et al. first described a form of noninvasive sinusitis in adults, which was histologically identical to allergic bronchopulmonary aspergillosis, with mucin-containing eosinophils, Charcot-Leyden crystals, and fungal elements resembling Aspergillus species [18].

Gene context of Aspergillosis, Allergic Bronchopulmonary

• STUDY OBJECTIVE: To assess the frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in patients with allergic bronchopulmonary aspergillosis (ABPA) [19].
• Immunohistochemical detection of GM-CSF, IL-4 and IL-5 in a murine model of allergic bronchopulmonary aspergillosis [20].
• Tumor necrosis factor-alpha and interleukin-1 alpha expression in a murine model of allergic bronchopulmonary aspergillosis [21].
• Respiratory exposure to A. fumigatus spores also causes allergic bronchopulmonary aspergillosis, a Th2 CD4+-T-cell-mediated disease that accompanies asthma [22].
• Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis [15].

Analytical, diagnostic and therapeutic context of Aspergillosis, Allergic Bronchopulmonary

• This was compared with standard culture filtrates by diverse analytic techniques including immunoblotting with sera of patients with pulmonary aspergilloma (PA) and allergic bronchopulmonary aspergillosis (ABPA) [23].
• The immunogenicity of the PABA-requiring mutant was comparable with that of a wild strain of the fungus in agar gel double-diffusion tests using clinical and hyperimmune sera and in skin tests on patients with allergic bronchopulmonary aspergillosis [24].
• Analysis of sera from patients suffering from allergic asthma, extrinsic allergic alveolitis (EAA) due to Aspergillus fumigatus or allergic bronchopulmonary aspergillosis (ABPA) by means of IEF immunoprint and Western blot showed characteristic IgG subclasses and IgE responses [25].
• CS2 reacts on immunoelectrophoresis, producing one major precipitin arc with aspergilloma or allergic bronchopulmonary aspergillosis (ABPA) patient sera [26].
• Nine fractions ranging from 900 to 10 kDa were used in ELISA and in a radioallergosorbent test (RAST) with sera from cases of allergic bronchopulmonary aspergillosis (ABPA) and from cystic fibrosis (CF) patients with ABPA or other Aspergillus involvement and compared with control subjects [27].

References