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Gene Review

Il1a  -  interleukin 1 alpha

Mus musculus

Synonyms: IL-1 alpha, Il-1a, Interleukin-1 alpha
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Disease relevance of Il1a


Psychiatry related information on Il1a


High impact information on Il1a


Chemical compound and disease context of Il1a


Biological context of Il1a


Anatomical context of Il1a


Associations of Il1a with chemical compounds


Regulatory relationships of Il1a


Other interactions of Il1a

  • The addition of IL-1 alpha to culture stimulated the release of both TNF alpha and GM-CSF and acted synergistically with both cytokines, resulting in a dose-dependent suppression of BFU-E and stimulation of CFU-GM growth [25].
  • The results demonstrated that IL-1 alpha does not directly influence the proliferation or differentiation of purified CFU-GM in the presence of plateau concentrations of purified natural or recombinant CSFs, and IL-1 alpha lacks intrinsic CSF activity of its own [23].
  • The direct synergistic effect of IL-1 alpha on CSF-1-induced progenitor growth was observed in all progenitor populations examined (Lin-, Lin-Thy-1+, and Lin-Thy-1-) and was inhibited by MoAb 35F5 [29].
  • Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization [34].
  • However, IL-1 alpha and IL-6 mRNA levels in diestrous epithelial cells, like those in D1 epithelial cells, increased in culture [35].

Analytical, diagnostic and therapeutic context of Il1a


  1. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Chensue, S.W., Terebuh, P.D., Remick, D.G., Scales, W.E., Kunkel, S.L. Am. J. Pathol. (1991) [Pubmed]
  2. Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie. Campbell, I.L., Eddleston, M., Kemper, P., Oldstone, M.B., Hobbs, M.V. J. Virol. (1994) [Pubmed]
  3. Cytokine mRNA expression in livers of mice infected with Listeria monocytogenes. Wagner, R.D., Czuprynski, C.J. J. Leukoc. Biol. (1993) [Pubmed]
  4. Production of tumor necrosis factor alpha, interleukin-1 alpha, and interleukin-6 during murine coccidioidomycosis. Cox, R.A., Magee, D.M. Infect. Immun. (1995) [Pubmed]
  5. Tumor necrosis factor alpha, interleukin-1 alpha, interleukin-6, and prostaglandin E2 production in murine peritoneal macrophages infected with Ehrlichia risticii. van Heeckeren, A.M., Rikihisa, Y., Park, J., Fertel, R. Infect. Immun. (1993) [Pubmed]
  6. Endogenous Interleukin (IL)-1 alpha and IL-1 beta Are Crucial for Host Defense against Disseminated Candidiasis. Vonk, A.G., Netea, M.G., van Krieken, J.H., Iwakura, Y., van der Meer, J.W., Kullberg, B.J. J. Infect. Dis. (2006) [Pubmed]
  7. Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice. Furuzawa, M., Kuwahara, M., Ishii, K., Iwakura, Y., Tsubone, H. Exp. Anim. (2002) [Pubmed]
  8. Peripherally administered IL-1 alpha interferes with scopolamine-induced amnesia in mice. Bianchi, M., Panerai, A.E. Brain research. Cognitive brain research. (1993) [Pubmed]
  9. Intestinal production of interleukin-1 alpha during endotoxemia in the mouse. Mester, M., Tompkins, R.G., Gelfand, J.A., Dinarello, C.A., Burke, J.F., Clark, B.D. J. Surg. Res. (1993) [Pubmed]
  10. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J. Cell (1995) [Pubmed]
  11. Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. Zúñiga-Pflücker, J.C., Di, J., Lenardo, M.J. Science (1995) [Pubmed]
  12. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Sims, J.E., March, C.J., Cosman, D., Widmer, M.B., MacDonald, H.R., McMahan, C.J., Grubin, C.E., Wignall, J.M., Jackson, J.L., Call, S.M. Science (1988) [Pubmed]
  13. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. You, M., Flick, L.M., Yu, D., Feng, G.S. J. Exp. Med. (2001) [Pubmed]
  14. The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells. de Vries, P., Brasel, K.A., Eisenman, J.R., Alpert, A.R., Williams, D.E. J. Exp. Med. (1991) [Pubmed]
  15. Acute hemorrhagic necrosis of tumors induced by interleukin-1 alpha: effects independent of tumor necrosis factor. Johnson, C.S., Chang, M.J., Braunschweiger, P.G., Furmanski, P. J. Natl. Cancer Inst. (1991) [Pubmed]
  16. IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts. Onoe, Y., Miyaura, C., Kaminakayashiki, T., Nagai, Y., Noguchi, K., Chen, Q.R., Seo, H., Ohta, H., Nozawa, S., Kudo, I., Suda, T. J. Immunol. (1996) [Pubmed]
  17. Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1 alpha production in mouse marrow cultures. Nishihara, T., Ueda, N., Amano, K., Ishihara, Y., Hayakawa, H., Kuroyanagi, T., Ohsaki, Y., Nagata, K., Noguchi, T. Infect. Immun. (1995) [Pubmed]
  18. Differential inhibition of IL-1 alpha and TNF-alpha generation by ammonium metavanadate in murine macrophages. Vaddi, K., Wei, C. Journal of toxicology and environmental health. (1996) [Pubmed]
  19. In vivo effect of interleukin-1 alpha on hematopoiesis: role of colony-stimulating factor receptor modulation. Hestdal, K., Jacobsen, S.E., Ruscetti, F.W., Dubois, C.M., Longo, D.L., Chizzonite, R., Oppenheim, J.J., Keller, J.R. Blood (1992) [Pubmed]
  20. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Yamada, K., Takane-Gyotoku, N., Yuan, X., Ichikawa, F., Inada, C., Nonaka, K. Diabetologia (1996) [Pubmed]
  21. Tumor necrosis factor-alpha and interleukin-1 alpha enhance glucose utilization by astrocytes: involvement of phospholipase A2. Yu, N., Maciejewski-Lenoir, D., Bloom, F.E., Magistretti, P.J. Mol. Pharmacol. (1995) [Pubmed]
  22. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Kuida, K., Lippke, J.A., Ku, G., Harding, M.W., Livingston, D.J., Su, M.S., Flavell, R.A. Science (1995) [Pubmed]
  23. Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony-stimulating factors. Williams, D.E., Broxmeyer, H.E. Blood (1988) [Pubmed]
  24. Over-expression of c-src or v-src in bone marrow stromal cells stimulates hematopoiesis in long-term bone marrow culture. Mladenovic, J., Anderson, S.M. Blood (1992) [Pubmed]
  25. The role of macrophages in the regulation of erythroid colony growth in vitro. Wang, C.Q., Udupa, K.B., Lipschitz, D.A. Blood (1992) [Pubmed]
  26. In vivo control of differentiation of myeloid leukemic cells by cyclosporine A and recombinant interleukin-1 alpha. Lotem, J., Sachs, L. Blood (1988) [Pubmed]
  27. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. Bogdan, C., Paik, J., Vodovotz, Y., Nathan, C. J. Biol. Chem. (1992) [Pubmed]
  28. Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. De, M., Sanford, T.R., Wood, G.W. Dev. Biol. (1992) [Pubmed]
  29. Interleukin-1 (IL-1) directly and indirectly promotes hematopoietic cell growth through type I IL-1 receptor. Hestdal, K., Ruscetti, F.W., Chizzonite, R., Ortiz, M., Gooya, J.M., Longo, D.L., Keller, J.R. Blood (1994) [Pubmed]
  30. Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta. Wheeler, R.D., Brough, D., Le Feuvre, R.A., Takeda, K., Iwakura, Y., Luheshi, G.N., Rothwell, N.J. J. Neurochem. (2003) [Pubmed]
  31. Tumor necrosis factor alpha and interleukin-1 alpha inhibit through different pathways interferon-gamma-induced antigen presentation, processing and MHC class II surface expression on astrocytes, but not on microglia. Gresser, O., Hein, A., Riese, S., Régnier-Vigouroux, A. Cell Tissue Res. (2000) [Pubmed]
  32. The induction of cytokine gene expression in murine peritoneal macrophages by Pseudostellaria heterophylla. Wong, C.K., Leung, K.N., Fung, M.C., Fung, K.P., Choy, Y.M. Immunopharmacology and immunotoxicology. (1994) [Pubmed]
  33. Secretion and hormonal regulation of interleukin-6 production by mouse uterine stromal and polarized epithelial cells cultured in vitro. Jacobs, A.L., Sehgal, P.B., Julian, J., Carson, D.D. Endocrinology (1992) [Pubmed]
  34. Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization. Ostrowski, J., Meier, K.E., Stanton, T.H., Smith, L.L., Bomsztyk, K. J. Biol. Chem. (1988) [Pubmed]
  35. Differential expression and regulation of cytokine genes in the mouse uterus. Kover, K., Liang, L., Andrews, G.K., Dey, S.K. Endocrinology (1995) [Pubmed]
  36. Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures. Schreiber, S., Kilgus, O., Payer, E., Kutil, R., Elbe, A., Mueller, C., Stingl, G. J. Immunol. (1992) [Pubmed]
  37. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. Joosten, L.A., Helsen, M.M., van de Loo, F.A., van den Berg, W.B. Arthritis Rheum. (1996) [Pubmed]
  38. Production of both interleukin-1 alpha and beta by newborn mouse calvarial cultures. Lorenzo, J.A., Sousa, S.L., Van den Brink-Webb, S.E., Korn, J.H. J. Bone Miner. Res. (1990) [Pubmed]
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