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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Thoracostomy

  • In this prospective, randomized comparison of two well-established pleurodesis procedures, 36 patients with malignant pleural effusions, expanded lungs after drainage, and expected survival of > 1 mo received either bleomycin instillation (60E) via a small-bore thoracostomy tube or thoracoscopic talc poudrage (5 g) under local anesthesia [1].
  • METHODS: Twenty-seven patients with congenital scoliosis associated with fused ribs of the concave hemithorax had an opening wedge thoracostomy with primary longitudinal lengthening with use of a chest-wall distractor known as a vertical, expandable prosthetic titanium rib [2].
  • We used intrapleural instillation of quinacrine hydrochloride in 20 patients (Group A) with recurrent spontaneous pneumothorax (one bilateral) and compared their clinical course with 19 patients who underwent thoracotomy and scarification or pleurectomy (Group B) and 63 patients treated by tube thoracostomy alone (Group C) [3].
  • Therapy of empyema associated with C. sordelli should consist of tube thoracostomy as well as penicillin with or without metronidazole or the combination of vancomycin and metronidazole in penicillin-allergic patients [4].

High impact information on Thoracostomy


Chemical compound and disease context of Thoracostomy


Associations of Thoracostomy with chemical compounds


Gene context of Thoracostomy

  • The objective of this study was to evaluate the effectiveness and safety of intrapleural tissue plasminogen activator (tPA) in children who require tube thoracostomy for drainage of a complicated parapneumonic effusion [15].
  • CONCLUSIONS: Tube thoracostomy can be safely performed by pulmonologists with relatively few associated problems [16].
  • CONCLUSION: Image-guided drainage with adjunctive pleural urokinase therapy is a safe and effective method of closed thoracostomy drainage of complicated pleural fluid collections and can obviate surgery in most cases [17].
  • The authors report 2 cases of tumor recurrence at thoracostomy tube insertion sites after intraoperative gross spillage of pleuropulmonary blastoma and malignant epithelial thymoma and discuss approaches that may potentially prevent this devastating complication [18].

Analytical, diagnostic and therapeutic context of Thoracostomy


  1. Prospective randomized comparison of thoracoscopic talc poudrage under local anesthesia versus bleomycin instillation for pleurodesis in malignant pleural effusions. Diacon, A.H., Wyser, C., Bolliger, C.T., Tamm, M., Pless, M., Perruchoud, A.P., Solèr, M. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  2. The effect of opening wedge thoracostomy on thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. Campbell, R.M., Smith, M.D., Mayes, T.C., Mangos, J.A., Willey-Courand, D.B., Kose, N., Pinero, R.F., Alder, M.E., Duong, H.L., Surber, J.L. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  3. Intrapleural instillation of quinacrine for treatment of recurrent spontaneous pneumothorax. Larrieu, A.J., Tyers, G.F., Williams, E.H., O'Neill, M.J., Derrick, J.R. Ann. Thorac. Surg. (1979) [Pubmed]
  4. Empyema caused by Clostridium sordellii, a rare form of pleuropulmonary disease. Buchman, A.L., Ponsillo, M., Nagami, P.H. J. Infect. (1991) [Pubmed]
  5. Parapneumonic effusions. Light, R.W., Girard, W.M., Jenkinson, S.G., George, R.B. Am. J. Med. (1980) [Pubmed]
  6. Intrapleural fibrinolysis for parapneumonic effusion and empyema in children. Wells, R.G., Havens, P.L. Radiology. (2003) [Pubmed]
  7. Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural effusions. Villanueva, A.G., Gray, A.W., Shahian, D.M., Williamson, W.A., Beamis, J.F. Thorax (1994) [Pubmed]
  8. Assessment of esophageal leak with oral fluorescein. Brevetti, G.R., Napierkowski, M.T., Maher, J.W. Am. J. Gastroenterol. (1997) [Pubmed]
  9. Effects of additional minocycline pleurodesis after thoracoscopic procedures for primary spontaneous pneumothorax. Chen, J.S., Hsu, H.H., Kuo, S.W., Tsai, P.R., Chen, R.J., Lee, J.M., Lee, Y.C. Chest (2004) [Pubmed]
  10. A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions. Putnam, J.B., Light, R.W., Rodriguez, R.M., Ponn, R., Olak, J., Pollak, J.S., Lee, R.B., Payne, D.K., Graeber, G., Kovitz, K.L. Cancer (1999) [Pubmed]
  11. Interpleural analgesia after thoracotomy. Ferrante, F.M., Chan, V.W., Arthur, G.R., Rocco, A.G. Anesth. Analg. (1991) [Pubmed]
  12. Nitrobule tetrazolium test in the diagnosis of pleural effusions. Light, R.W., George, R.B. Chest (1981) [Pubmed]
  13. Open thoracotomy and pleural abrasion in the treatment of spontaneous pneumothorax in cystic fibrosis. Rich, R.H., Warwick, W.J., Leonard, A.S. J. Pediatr. Surg. (1978) [Pubmed]
  14. Thoracostomy tube in an interlobar fissure: radiologic recognition of a potential problem. Maurer, J.R., Friedman, P.J., Wing, V.W. AJR. American journal of roentgenology. (1982) [Pubmed]
  15. Effectiveness and safety of tissue plasminogen activator in the management of complicated parapneumonic effusions. Weinstein, M., Restrepo, R., Chait, P.G., Connolly, B., Temple, M., Macarthur, C. Pediatrics (2004) [Pubmed]
  16. Analysis of tube thoracostomy performed by pulmonologists at a teaching hospital. Collop, N.A., Kim, S., Sahn, S.A. Chest (1997) [Pubmed]
  17. Treatment of complicated pleural fluid collections with image-guided drainage and intracavitary urokinase. Moulton, J.S., Benkert, R.E., Weisiger, K.H., Chambers, J.A. Chest (1995) [Pubmed]
  18. Tumor recurrence at thoracostomy tube insertion sites: a report of two pediatric cases. Hayes-Jordan, A.A., Daw, N.C., Furman, W.L., Hoffer, F.A., Shochat, S.J. J. Pediatr. Surg. (2004) [Pubmed]
  19. Diaphragmatic injury: a method for early diagnosis. Shea, L., Graham, A.D., Fletcher, J.C., Watkins, G.M. The Journal of trauma. (1982) [Pubmed]
  20. Spontaneous pneumothorax after steroid treatment in a patient with bronchiolitis obliterans organizing pneumonia. Lee, P.C., Lin, J.H., Lin, C.H., Chien, S.T., Hsu, J.Y., Feng, N.H. J. Formos. Med. Assoc. (2005) [Pubmed]
  21. Congenital chylothorax. Ozkan, H., Ay, N., Ozaksoy, D., Ercal, D., Erata, Y., Durak, H., Evyapan, O., Toprak, S. Turk. J. Pediatr. (1996) [Pubmed]
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