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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Patient Dropouts

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Disease relevance of Patient Dropouts

  • Using a 'dropouts as censored' analysis, plasma HIV RNA < or = 400 copies/ml was observed in 93% (25/27), 73% (11/15) and 25% (2/8) of subjects with <10-fold, 10- to 40-fold, and >40-fold reduced susceptibility to lopinavir at baseline, respectively [1].
  • The patient dropout rate per infection for MRSA infections was comparable to Pseudomonas and fungal infections, but was significantly higher than MSSA infections (P < 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)[2]
  • MRSA nasal carriage was associated with a significant increase in the rate of peritonitis (P < 0.01) and exit-site infections (P < 0.01), the number of catheter losses, and CAPD patient dropout (P < 0.001) [2].
  • The two phenylpropanolamine studies gave the same weight losses, but the dropouts were 37% at 8 weeks for free care vs. 11% for contingency contracting (p<0.001) [3].
  • In conclusion, a regimen of losartan, when compared with a regimen of nifedipine GITS, provides comparable efficacy, and with respect to edema, superior tolerability, less bother to patients, and fewer therapy dropouts [4].

Psychiatry related information on Patient Dropouts


High impact information on Patient Dropouts

  • The group treated with methadyl acetate had more dropouts in the first seven weeks than the second seven weeks: this pattern was reversed for the methadone-treated group [8].
  • Seven dropouts occurred in the D-cycloserine group and 1 in the placebo group [9].
  • Induction with higher LAAM doses can be safely achieved within 17 days, but may result in greater rates of patient dropout and opioid agonist adverse effects [10].
  • In conclusion, our data do not confirm the supposed increased risk for IFN-alpha-induced mental side effects and dropouts in psychiatric patients if interdisciplinary care and antidepressant treatment are available [11].
  • This simple assay should detect a great variety of insertion/deletion mutations in the NF1mRNA internal to the primer binding sites, including all possible single and multiple exon dropouts and approximately 30% of all previously reported NF1 mutations [12].

Chemical compound and disease context of Patient Dropouts

  • There were three dropouts in the placebo group (progressive heart failure requiring antiotensin-converting enzyme inhibition) and one dropout in the enalapril group (malignant ventricular arrhythmias) [13].

Biological context of Patient Dropouts

  • Although there was a trend for more dropouts by subjects taking desipramine, there were no significant differences among treatment groups regarding retention in treatment, craving for cocaine, and decreased cocaine use confirmed by urine toxicology [14].

Anatomical context of Patient Dropouts

  • The secondary refusal includes dropouts after one or more unsuccessful IVF-treatments mainly influenced by the outcome of previous cycles (prognostic factors: oocyte and embryo count, embryo quality, females age) associated with psychological and emotional aspects [15].

Associations of Patient Dropouts with chemical compounds

  • There were significantly more dropouts due to side effects from imipramine (48%) than from both paroxetine (20%) and placebo (24%) [16].
  • There were significantly fewer episodes and dropouts due to depression in the lithium-treated than in the placebo-treated bipolar I patients [17].
  • Amisulpride was associated with clearly lower use of antiparkinsonian medication and with fewer dropouts due to adverse events than conventional antipsychotics [18].
  • Thirty-eight patients were randomly assigned to increase dietary polyunsaturated:saturated fatty acids ratio to 1.0 by replacement of saturated fat with linoleic-acid-rich products (n = 18, two dropouts, analysis was performed in n = 16) or to continue their usual diet (n = 20) [19].
  • The fluoxetine group had more dropouts (28/49, 57.1%) than the dexfenfluramine group (17/47, 36.2%), with an intermediate number of dropouts from the placebo group (21/48, 43.8%) [20].

Gene context of Patient Dropouts

  • Reduced burden of disease and improved outcome of patients with rheumatoid factor positive rheumatoid arthritis compared with dropouts. A 10 year observational study [21].
  • Twenty patients were randomized into the erythropoietin group with three observed dropouts and 10 patients into the placebo group [22].
  • Phase I (dropouts excluded) meta-analysis confirmed data homogeneity across study sites, that TEN and TPN groups were comparable, and that significantly fewer TEN patients experienced septic complications (TEN, 18%; TPN, 35%; p = 0.01) [23].
  • When similar analyses were carried out adjusting for different patterns of patient dropout, there were no significant differences between the two groups at any time point in terms of PCS, MCS, and KDCS scores [24].
  • No substantial difference among the three groups was observed in the prothrombin times, the dosage of the anticoagulant, the bleeding complications, and the dropouts [25].

Analytical, diagnostic and therapeutic context of Patient Dropouts


  1. Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy. Kempf, D.J., Isaacson, J.D., King, M.S., Brun, S.C., Sylte, J., Richards, B., Bernstein, B., Rode, R., Sun, E. Antivir. Ther. (Lond.) (2002) [Pubmed]
  2. Methicillin-resistant Staphylococcus aureus nasal carriage and infections in CAPD. Lye, W.C., Leong, S.O., Lee, E.J. Kidney Int. (1993) [Pubmed]
  3. Methods to maximize retention in weight loss studies. Greenway, F.L., Bray, G.A., Marlin, R.L. Obes. Res. (1999) [Pubmed]
  4. Efficacy, tolerability, and quality of life of losartan, alone or with hydrochlorothiazide, versus nifedipine GITS in patients with essential hypertension. Weir, M.R., Elkins, M., Liss, C., Vrecenak, A.J., Barr, E., Edelman, J.M. Clinical therapeutics. (1996) [Pubmed]
  5. Sertraline maintenance treatment reduced relapse and dropouts in posttraumatic stress disorder. Bisson, J.I. ACP J. Club (2002) [Pubmed]
  6. A comparative study of cocaine-treatment completers and dropouts. McMahon, R.C., Kouzekanani, K., Malow, R.M. Journal of substance abuse treatment. (1999) [Pubmed]
  7. Comparisons of motivation, health behaviors, and functional status among elders in residential homes in Korea. Song, R., June, K.J., Kim, C.G., Jeon, M.Y. Public health nursing (Boston, Mass.) (2004) [Pubmed]
  8. Methadyl acetate and methadone. An open comparison. Senay, E.C., Dorus, W., Renault, P.F. JAMA (1977) [Pubmed]
  9. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Goff, D.C., Tsai, G., Levitt, J., Amico, E., Manoach, D., Schoenfeld, D.A., Hayden, D.L., McCarley, R., Coyle, J.T. Arch. Gen. Psychiatry (1999) [Pubmed]
  10. Induction with levomethadyl acetate: safety and efficacy. Jones, H.E., Strain, E.C., Bigelow, G.E., Walsh, S.L., Stitzer, M.L., Eissenberg, T., Johnson, R.E. Arch. Gen. Psychiatry (1998) [Pubmed]
  11. Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Schaefer, M., Schmidt, F., Folwaczny, C., Lorenz, R., Martin, G., Schindlbeck, N., Heldwein, W., Soyka, M., Grunze, H., Koenig, A., Loeschke, K. Hepatology (2003) [Pubmed]
  12. Long RT-PCR of the entire 8.5-kb NF1 open reading frame and mutation detection on agarose gels. Martinez, J.M., Breidenbach, H.H., Cawthon, R. Genome Res. (1996) [Pubmed]
  13. Beneficial clinical effect of very early enalapril treatment in patients with acute left ventricular failure complicating myocardial infarction. Hüttl, S., Nussberger, J., Lehmann, K., Hasford, J., Brunner, H.R., Delius, W. Clinical cardiology. (1995) [Pubmed]
  14. Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. Weddington, W.W., Brown, B.S., Haertzen, C.A., Hess, J.M., Mahaffey, J.R., Kolar, A.F., Jaffe, J.H. The American journal of drug and alcohol abuse. (1991) [Pubmed]
  15. Why do couples refuse or discontinue ART? Dawson, A.A., Diedrich, K., Felberbaum, R.E. Arch. Gynecol. Obstet. (2005) [Pubmed]
  16. Randomized, placebo-controlled trial of paroxetine versus imipramine in depressed HIV-positive outpatients. Elliott, A.J., Uldall, K.K., Bergam, K., Russo, J., Claypoole, K., Roy-Byrne, P.P. The American journal of psychiatry. (1998) [Pubmed]
  17. Lithium prophylaxis of depression in bipolar I, bipolar II, and unipolar patients. Fieve, R.R., Kumbaraci, T., Dunner, D.L. The American journal of psychiatry. (1976) [Pubmed]
  18. Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. Leucht, S., Pitschel-Walz, G., Engel, R.R., Kissling, W. The American journal of psychiatry. (2002) [Pubmed]
  19. Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion. Dullaart, R.P., Beusekamp, B.J., Meijer, S., Hoogenberg, K., van Doormaal, J.J., Sluiter, W.J. Diabetologia (1992) [Pubmed]
  20. Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. Spring, B., Wurtman, J., Wurtman, R., el-Khoury, A., Goldberg, H., McDermott, J., Pingitore, R. Am. J. Clin. Nutr. (1995) [Pubmed]
  21. Reduced burden of disease and improved outcome of patients with rheumatoid factor positive rheumatoid arthritis compared with dropouts. A 10 year observational study. Darmawan, J., Rasker, J.J., Nuralim, H. The Journal of rheumatology. Supplement. (2003) [Pubmed]
  22. Perisurgical erythropoietin application in anemic patients with colorectal cancer: A double-blind randomized study. Heiss, M.M., Tarabichi, A., Delanoff, C., Allgayer, H., Jauch, K.W., Hernandez-Richter, T., Mempel, W., Beck, K.G., Schildberg, F.W., Messmer, K. Surgery (1996) [Pubmed]
  23. Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Moore, F.A., Feliciano, D.V., Andrassy, R.J., McArdle, A.H., Booth, F.V., Morgenstein-Wagner, T.B., Kellum, J.M., Welling, R.E., Moore, E.E. Ann. Surg. (1992) [Pubmed]
  24. Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: The ADEMEX trial. Paniagua, R., Amato, D., Vonesh, E., Guo, A., Mujais, S. Kidney Int. (2005) [Pubmed]
  25. Prospective double-blind clinical trial of bovine, human, and rabbit thromboplastins in monitoring long-term oral anticoagulation. Boekhout-Mussert, M.J., van der Kolk-Schaap, P.J., Hermans, J., Loeliger, E.A. Am. J. Clin. Pathol. (1981) [Pubmed]
  26. Prognostic factors in patients continuing in vitro fertilization or intracytoplasmic sperm injection treatment and dropouts. De Vries, M.J., De Sutter, P., Dhont, M. Fertil. Steril. (1999) [Pubmed]
  27. Effect of dropouts in a longitudinal study: an application of a repeated ordinal model. Lesaffre, E., Molenberghs, G., Dewulf, L. Statistics in medicine. (1996) [Pubmed]
  28. Double-blind placebo-controlled study of milnacipran in hospitalized patients with major depressive disorders. Macher, J.P., Sichel, J.P., Serre, C., Von Frenckell, R., Huck, J.C., Demarez, J.P. Neuropsychobiology (1989) [Pubmed]
  29. Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Skoutakis, V.A., Carter, C.A., Mickle, T.R., Smith, V.H., Arkin, C.R., Alissandratos, J., Petty, D.E. Drug intelligence & clinical pharmacy. (1988) [Pubmed]
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