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Disease relevance of Ganglioglioma


High impact information on Ganglioglioma

  • In the present study, we investigated the clonality of eight gangliogliomas from female patients using both methylation- and transcription-based clonality assays at the androgen receptor locus (HUMARA) on the X chromosome [6].
  • In a series of 326 gangliogliomas collected from the University of Bonn Epilepsy Surgery Program and other departments of neuropathology in Germany, Austria, and Switzerland, epidemiological findings and histopathological hallmarks of gangliogliomas are systematically reviewed [7].
  • The reelin signaling and tuberin/insulin growth receptor pathways have recently been implicated in ganglioglioma development [7].
  • Novel cerebral lesions in the Eker rat model of tuberous sclerosis: cortical tuber and anaplastic ganglioglioma [8].
  • The fact that both gangliogliomas and cortical tubers in tuberous sclerosis contain neuronal and astrocytic elements and may resemble each other histologically suggests that the TSC2 gene may be involved in the development of these tumors [9].

Chemical compound and disease context of Ganglioglioma


Biological context of Ganglioglioma


Anatomical context of Ganglioglioma


Gene context of Ganglioglioma

  • We observed coexpression of CD34 and NFM, suggesting neuronal differentiation of the CD34 expressing cellular elements in gangliogliomas [23].
  • The cell-specific distribution of multidrug resistance extrusion pumps was studied in developmental glioneuronal lesions, including focal cortical dysplasia (15 cases) and ganglioglioma (15 cases) from patients with medically intractable epilepsy [24].
  • Accumulation of band-4.1 proteins has been identified in cortical tubers of tuberous sclerosis patients, which share neuropathological similarities with FCD and gangliogliomas [25].
  • The authors report here the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component [26].
  • Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas [16].

Analytical, diagnostic and therapeutic context of Ganglioglioma


  1. Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. Hunter, S., Young, A., Olson, J., Brat, D.J., Bowers, G., Wilcox, J.N., Jaye, D., Mendrinos, S., Neish, A. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  2. The clinical significance of extracellular matrix in gangliogliomas. Jaffey, P.B., Mundt, A.J., Baunoch, D.A., Armstrong, D.L., Hamilton, W.J., Zagaja, V.G., Grossman, R.G., Wollmann, R.L. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  3. Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. Smith, T.W., Lippa, C.F. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  4. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells. Kemshead, J.T., Fritschy, J., Garson, J.A., Allan, P., Coakham, H., Brown, S., Asser, U. Int. J. Cancer (1983) [Pubmed]
  5. Epilepsy surgery in infants. Wyllie, E., Comair, Y.G., Kotagal, P., Raja, S., Ruggieri, P. Epilepsia (1996) [Pubmed]
  6. Evidence for clonal origin of neoplastic neuronal and glial cells in gangliogliomas. Zhu, J.J., Leon, S.P., Folkerth, R.D., Guo, S.Z., Wu, J.K., Black, P.M. Am. J. Pathol. (1997) [Pubmed]
  7. Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. Blümcke, I., Wiestler, O.D. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  8. Novel cerebral lesions in the Eker rat model of tuberous sclerosis: cortical tuber and anaplastic ganglioglioma. Mizuguchi, M., Takashima, S., Yamanouchi, H., Nakazato, Y., Mitani, H., Hino, O. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  9. A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. Platten, M., Meyer-Puttlitz, B., Blümcke, I., Waha, A., Wolf, H.K., Nöthen, M.M., Louis, D.N., Sampson, J.R., von Deimling, A. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  10. Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. Aronica, E., Yankaya, B., Jansen, G.H., Leenstra, S., van Veelen, C.W., Gorter, J.A., Troost, D. Neuropathol. Appl. Neurobiol. (2001) [Pubmed]
  11. Gangliogliomas: characterization by registered positron emission tomography-MR images. Provenzale, J.M., Arata, M.A., Turkington, T.G., McLendon, R.E., Coleman, R.E. AJR. American journal of roentgenology. (1999) [Pubmed]
  12. Ultrastructural identification of protein bodies, cellular markers of human catecholamine neurons, in a temporal lobe ganglioglioma. Issidorides, M.R., Havaki, S., Chrysanthou-Piterou, M., Arvanitis, D.L. Ultrastructural pathology. (2000) [Pubmed]
  13. Brainstem Gliomas. A 10-year institutional review. Farmer, J.P., Montes, J.L., Freeman, C.R., Meagher-Villemure, K., Bond, M.C., O'Gorman, A.M. Pediatric neurosurgery. (2001) [Pubmed]
  14. Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with intracranial tumors. Prayson, R.A., Khajavi, K., Comair, Y.G. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  15. Mutational analysis of TSC1 and TSC2 genes in gangliogliomas. Becker, A.J., Löbach, M., Klein, H., Normann, S., Nöthen, M.M., von Deimling, A., Mizuguchi, M., Elger, C.E., Schramm, J., Wiestler, O.D., Blümcke, I. Neuropathol. Appl. Neurobiol. (2001) [Pubmed]
  16. Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. Becker, A.J., Klein, H., Baden, T., Aigner, L., Normann, S., Elger, C.E., Schramm, J., Wiestler, O.D., Blümcke, I. Acta Neuropathol. (2002) [Pubmed]
  17. Anaplastic ganglioglioma with sarcomatous component: an immunohistochemical study and molecular analysis of p53 tumor suppressor gene. Suzuki, H., Otsuki, T., Iwasaki, Y., Katakura, R., Asano, H., Tadokoro, M., Suzuki, Y., Tezuka, F., Takei, H. Neuropathology : official journal of the Japanese Society of Neuropathology. (2002) [Pubmed]
  18. Molecular markers of primitive neuroectodermal tumors and other pediatric central nervous system tumors. Monoclonal antibodies to neuronal and glial antigens distinguish subsets of primitive neuroectodermal tumors. Molenaar, W.M., Jansson, D.S., Gould, V.E., Rorke, L.B., Franke, W.W., Lee, V.M., Packer, R.J., Trojanowski, J.Q. Lab. Invest. (1989) [Pubmed]
  19. Evidence for developmental precursor lesions in epilepsy-associated glioneuronal tumors. Blümcke, I., Löbach, M., Wolf, H.K., Wiestler, O.D. Microsc. Res. Tech. (1999) [Pubmed]
  20. Temporal lobe ganglioglioma in refractory epilepsy: CT and MR in three cases. Chamberlain, M.C., Press, G.A. J. Neurooncol. (1990) [Pubmed]
  21. Pleomorphic xanthoastrocytoma with gangliogliomatous component. Vajtai, I., Varga, Z., Aguzzi, A. Pathol. Res. Pract. (1997) [Pubmed]
  22. The significance of immunocytochemical markers, synaptophysin and neurofilaments in diagnosis of ganglioglioma. Wierzba-Bobrowicz, T., Schmidt-Sidor, B., Gwiazda, E., Bertrand, E. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (1999) [Pubmed]
  23. In situ-RT and immunolaser microdissection for mRNA analysis of individual cells isolated from epilepsy-associated glioneuronal tumors. Fassunke, J., Majores, M., Ullmann, C., Elger, C.E., Schramm, J., Wiestler, O.D., Becker, A.J. Lab. Invest. (2004) [Pubmed]
  24. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors. Aronica, E., Gorter, J.A., Jansen, G.H., van Veelen, C.W., van Rijen, P.C., Leenstra, S., Ramkema, M., Scheffer, G.L., Scheper, R.J., Troost, D. Neuroscience (2003) [Pubmed]
  25. Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions. Majores, M., Schick, V., Engels, G., Fassunke, J., Elger, C.E., Schramm, J., Blümcke, I., Becker, A.J. Acta Neuropathol. (2005) [Pubmed]
  26. Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma. Fukushima, T., Katayama, Y., Watanabe, T., Yoshino, A., Komine, C., Yokoyama, T. J. Neurooncol. (2005) [Pubmed]
  27. Bcl-2 and Bcl-X expression in gangliogliomas. Prayson, R.A. Hum. Pathol. (1999) [Pubmed]
  28. Dysembryoplastic neuroepithelial tumors: MR findings. Kuroiwa, T., Kishikawa, T., Kato, A., Ueno, M., Kudo, S., Tabuchi, K. Journal of computer assisted tomography. (1994) [Pubmed]
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