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MeSH Review

Hypervitaminosis A

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Disease relevance of Hypervitaminosis A


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Chemical compound and disease context of Hypervitaminosis A


Biological context of Hypervitaminosis A


Anatomical context of Hypervitaminosis A


Gene context of Hypervitaminosis A

  • This observation suggests that the high levels of free holo-RBP, not bound to TTR, which correspond to the increase in total RBPs measured in CRF serum, may alter the tissue uptake of retinol and be responsible for the signs of hypervitaminosis A observed in these patients [24].
  • Even at doses that produced overt signs of hypervitaminosis A and mortality, minimal or no changes were observed in the testes [25].
  • Early changes in the mouse neuroepithelium preceding exencephaly induced by hypervitaminosis A [26].
  • In comparison with matched controls, total enzymic activities in with hypervitaminosis A animals were nearly double for lactase, sucrase and maltase in all segments [27].
  • Hypervitaminosis A and retinoic acid treatment increased plasma TPA activity by approximately 50%, but PAI-1 activity was not affected [28].


  1. Hypervitaminosis A unmasked by acute viral hepatitis. Hatoff, D.E., Gertler, S.L., Miyai, K., Parker, B.A., Weiss, J.B. Gastroenterology (1982) [Pubmed]
  2. Serum vitamin A concentration is elevated in idiopathic intracranial hypertension. Jacobson, D.M., Berg, R., Wall, M., Digre, K.B., Corbett, J.J., Ellefson, R.D. Neurology (1999) [Pubmed]
  3. The safety of beta-carotene. Bendich, A. Nutrition and cancer. (1988) [Pubmed]
  4. Plasma retinol and retinol binding protein concentrations in patients on maintenance haemodialysis with and without vitamin A supplements. Stewart, W.K., Fleming, L.W. Nephron (1982) [Pubmed]
  5. New aspects of the tolerance of retinol in humans. Körner, W.F., Völlm, J. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1975) [Pubmed]
  6. Possible role of endogenous retinoid (Vitamin A) toxicity in the pathophysiology of primary biliary cirrhosis. Erickson, J.M., Mawson, A.R. J. Theor. Biol. (2000) [Pubmed]
  7. Vitamin A transport in human vitamin A toxicity. Smith, F.R., Goodman, D.S. N. Engl. J. Med. (1976) [Pubmed]
  8. Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A. James, D.R., Owen, G., Campbell, I.A., Goodchild, M.C. Gut (1992) [Pubmed]
  9. Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes. Iwamoto, M., Shapiro, I.M., Yagami, K., Boskey, A.L., Leboy, P.S., Adams, S.L., Pacifici, M. Exp. Cell Res. (1993) [Pubmed]
  10. Pseudotumor cerebri caused by a synthetic vitamin A preparation. Spector, R.H., Carlisle, J. Neurology (1984) [Pubmed]
  11. Pharmacokinetics and therapeutic efficacy of retinoids in skin diseases. Larsen, F.G., Nielsen-Kudsk, F., Jakobsen, P., Weismann, K., Kragballe, K. Clinical pharmacokinetics. (1992) [Pubmed]
  12. Canthaxanthin and excess vitamin A alter alpha-tocopherol, carotenoid and iron status in adult rats. Blakely, S.R., Mitchell, G.V., Jenkins, M.Y., Grundel, E., Whittaker, P. J. Nutr. (1991) [Pubmed]
  13. Hypervitaminosis A in rainbow trout (Salmo gairdneri): toxicity signs and maximum tolerable level. Hilton, J.W. J. Nutr. (1983) [Pubmed]
  14. Stellate-cell lipidosis in liver biopsy specimens. Recognition and significance. Levine, P.H., Delgado, Y., Theise, N.D., West, A.B. Am. J. Clin. Pathol. (2003) [Pubmed]
  15. Early effects of vitamin A toxicity on hepatic glycolysis in rat. Singh, V.N., Singh, M., Dileepan, K.N. J. Nutr. (1978) [Pubmed]
  16. Inhibition of membrane bone formation by vitamin A in the embryonic chick mandible. Tyler, M.S., Dewitt-Stott, R.A. Anat. Rec. (1986) [Pubmed]
  17. Serum levels of vitamin A and retinol binding protein in chronic renal patients treated by continuous ambulatorial peritoneal dialysis. Vannucchi, M.T., Vannucchi, H., Humphreys, M. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1992) [Pubmed]
  18. Biological mechanisms and cardiovascular effects of omega-3 fatty acids. Mueller, B.A., Talbert, R.L. Clinical pharmacy. (1988) [Pubmed]
  19. Alterations in kidney enzyme pattern in acute hypervitaminosis A. Alarcón, O.M., Reinosa Fuller, J., García de Méndez, G., Agudelo, R., Carnevalí de Tatá, E., Silva, T. Archivos latinoamericanos de nutrición. (1998) [Pubmed]
  20. Fine structure and cytochemistry of lysosomes in the Ito cells of the rat liver. Yamamoto, K., Ogawa, K. Cell Tissue Res. (1983) [Pubmed]
  21. Effect of dietary protein and hypervitaminosis A or C on tissue peroxidation and erythrocyte lysis of vitamin E deficiency. Jayanthi Bai, N., Sanjeev Kumar, P., George, T., Krishnamurthy, S. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1982) [Pubmed]
  22. Lipid-laden perisinusoidal cells in patients with acquired immunodeficiency syndrome. Dupon, M., Kosaifi, T., Le Bail, B., Lacut, Y., Balabaud, C., Bioulac-Sage, P. Liver (1991) [Pubmed]
  23. Amniotic and maternal serum alpha-fetoprotein levels of rats with induced neural tube defects. Peters, P.W., Verhoef, A., Hagenaars, A.M. Acta morphologica Neerlando-Scandinavica. (1981) [Pubmed]
  24. Analysis of normal and truncated holo- and apo-retinol-binding protein (RBP) in human serum: altered ratios in chronic renal failure. Jaconi, S., Saurat, J.H., Siegenthaler, G. Eur. J. Endocrinol. (1996) [Pubmed]
  25. Studies on the testicular effects of vitamin A palmitate in the Sprague-Dawley rat. Bosakowski, T., Levin, A.A., Edgcomb, J.H. Food Chem. Toxicol. (1988) [Pubmed]
  26. Early changes in the mouse neuroepithelium preceding exencephaly induced by hypervitaminosis A. Theodosis, D.T., Fraser, F.C. Teratology (1978) [Pubmed]
  27. Effect of hypervitaminosis A on intestinal digestive & absorptive functions in rat. Sinha, M., Ghosh, A.K. Indian J. Med. Res. (1994) [Pubmed]
  28. Modulation of tissue-type plasminogen activator by retinoids in rat plasma and tissues. Van Bennekum, A.M., Emeis, J.J., Kooistra, T., Hendriks, H.F. Am. J. Physiol. (1993) [Pubmed]
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