Disease relevance of Intracranial Arteriosclerosis

• These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2) High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia [1].
• 3 of the patients also had symptoms related to cerebral arteriosclerosis and 2 had mild Parkinson's disease without levodopa therapy [2].
• Inflammatory markers, infection, homocysteine and sleep-disordered breathing rank as the four most important new risk factors in cerebral atherosclerosis [3].
• Iron deposits in ethionine induced aortic siderosis of rats, in splenic deposits in sickle cell anemia and siderocalcific vessels in cerebral arteriosclerosis were completely removed by exposure to 20 percent hydrochloric acid for 30 min [4].
• The first publications regarding clinical use of taurine were Italian reports claiming therapeutic efficacy in angina, intermittent claudication and symptomatic cerebral arteriosclerosis [5].

High impact information on Intracranial Arteriosclerosis

• Cerebral atherosclerosis in Japanese. Part 5: relationship between cholesterol deposition and glycosaminoglycans [6].
• Testing regional cerebral blood flow with CO2 appears to be a useful, harmless screening test for cerebral atherosclerosis [7].
• Caution should also be observed in patients with previous epilepsy or severe cerebral arteriosclerosis [8].
• The serum cholesterol level correlated better with the severity of aortic than cerebral atherosclerosis [9].
• The relationship between endothelin-1, event-related P300 potentials, and prognosis in cerebral arteriosclerosis [10].

Chemical compound and disease context of Intracranial Arteriosclerosis

• Cyclandelate in the treatment of cerebral arteriosclerosis [11].
• Using the xenon-133 inhalation method, we studied the age-related decline in regional cerebral blood flow, calculated as the initial slope index (ISI), in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (154 men and 123 women), ranging in age from 19 to 88 years [12].
• OBJECTIVES: To search for a potential role of endothelin-1 (ET-1), a potent vasoconstrictor and presumably neurotoxic 21-amino acid peptide, for dysfunction of brain signal processing and cerebrovascular morbidity in nondemented patients with cerebral arteriosclerosis [10].
• These data demonstrate that flunarizine treatment counteracts the haemodynamic effects of cerebral atherosclerosis [13].
• The ability of platelets to synthetise thromboxane B2 and hydroxylated fatty acids from arachidonic acid was studied simultaneously with arachidonic acid-induced aggregation in 42 patients suffering from severe cerebral atherosclerosis and also in 34 healthy controls [14].

Biological context of Intracranial Arteriosclerosis

• Cerebral vasodilator responses to hypercarbia were tested during inhalation of 5% CO2 in air by normal volunteers with and without risk factors for cerebral atherosclerosis [7].
• This article reviews the indications for endovascular stenting for cerebral aneurysms and intracranial atherosclerosis and describes the peri-procedure management and technique applied at the Department of Neurosurgery at the University at Buffalo [15].
• We investigated the correlation of the changes in hemostatic system (platelet aggregation, anti-thrombin III, D-dimer, protein C, factor VII, factor VIII, PAI-1) compared to the degree of cerebral atherosclerosis (ultrasonographically) and compared to the observed groups of patients [16].

Anatomical context of Intracranial Arteriosclerosis

• Effect of cardiac glycosides on the release of adenylate kinase into cerebrospinal fluid of patients with cerebral arteriosclerosis [17].
• The usefulness of the inhibitors on cyclic AMP phospodiesterase of arterial endothelial cells and platelets and on that of brain, such as EG467 AND EG626, has been suggested in the treatment of atherosclerotic disorders, especially of cerebral atherosclerosis [18].
• Bilateral basal ganglia infarctions in two patients were probably related to methanol intoxication and meningoencephalitis, and unilateral basal ganglia infarctions in two other patients were presumably due to cerebral atherosclerosis and/or hypertension [19].

Gene context of Intracranial Arteriosclerosis

• The degree of coronary or cerebral atherosclerosis was not related to the amount of amyloid accumulation in the frontal and temporal cortices or in the hippocampal structures [20].
• Diabetes mellitus (OR, 6.04; CI, 1.1 to 32.2; P=0.03) and a higher endostatin/VEGF ratio (OR, 15.7; CI, 2.2 to 112.3; P=0.006) were independently associated with a greater extent of intracranial atherosclerosis [21].
• Cerebral atherosclerosis in Japanese. Part 4: relationship between lipid content and macroscopic severity of atherosclerosis [22].
• Recently, however, a growing body of evidence seems to suggest that in certain pathological situations, such as human intracranial atherosclerosis, vasa vasorum are present [23].
• The approach to PAOD has come in a completely new light in medicine since it is has been recognised as a major marker of coronary or cerebral atherosclerosis [24].

References