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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Microtomy


High impact information on Microtomy

  • Ultrastructural changes of the luminal plasma membrane were studied with thin sectioning and freeze-fracturing techniques [3].
  • Ethanol treatment of the block face of the sample after microtomy elutes non-cross-linked polymer chains and makes the smallest details of the embedded biomaterial amenable to detection [4].
  • For the TEM examination, the sections were partly decalcified by an aqueous EDTA solution to facilitate ultramicrotomy and to disclose the ultrastructure of the interdiffusion zone [5].
  • Thin-sectioning studies confirmed the image features seen by other techniques, but the addition of tannic acid in the fixation procedure was required to visualize the structure [6].
  • Cryo-sectioning and chemical-fixing ultramicrotomy techniques for imaging rubber latex particle morphology [7].

Chemical compound and disease context of Microtomy


Anatomical context of Microtomy


Associations of Microtomy with chemical compounds


Gene context of Microtomy

  • The AFM images clearly demonstrated the enhanced potential of diamond-knife microtomy for nondestructively producing clean cross-sections through interfaces that allow the interfacial ultra-structure to be imaged by AFM with a resolution equaling that of TEM [18].
  • Using dual immunostaining and thin sectioning techniques, the ventrolateral SCN of light-exposed rats was examined for evidence of individual neurons coexpressing nuclear immunostaining for c-fos proteins (Fos) with cytoplasmic immunoreactivity for GRP or VIP [19].

Analytical, diagnostic and therapeutic context of Microtomy


  1. Pigment containing lipid vesicles. I. Preparation and characterization of chlorophyll a-lecithin vesicles. Ritt, E., Walz, D. J. Membr. Biol. (1976) [Pubmed]
  2. Comparative ultrastructure of selected oral streptococci: thin-sectioning and freeze-etching studies. Holt, S.C., Leadbetter, E.R. Can. J. Microbiol. (1976) [Pubmed]
  3. Luminal plasma membrane organization in rat urinary bladder urothelium after direct exposure in vivo to N-methyl-N-nitrosourea. Hainau, B. Cancer Res. (1979) [Pubmed]
  4. AFM of biological material embedded in epoxy resin. Matsko, N., Mueller, M. J. Struct. Biol. (2004) [Pubmed]
  5. Comparative SEM and TEM examination of the ultrastructure of the resin-dentin interdiffusion zone. Van Meerbeek, B., Dhem, A., Goret-Nicaise, M., Braem, M., Lambrechts, P., VanHerle, G. J. Dent. Res. (1993) [Pubmed]
  6. Periodic surface array in Caulobacter crescentus: fine structure and chemical analysis. Smit, J., Grano, D.A., Glaeser, R.M., Agabian, N. J. Bacteriol. (1981) [Pubmed]
  7. Cryo-sectioning and chemical-fixing ultramicrotomy techniques for imaging rubber latex particle morphology. Subramaniam, N., Simpson, A., Monteiro, M.J., Shaffer, O., Fellows, C.M., Gilbert, R.G. Microsc. Res. Tech. (2004) [Pubmed]
  8. A simple method for maintaining relative positions of separate tissue elements during processing for electron microscopy. Stirling, C.A. Journal of microscopy. (1978) [Pubmed]
  9. Two types of presynaptic configurations in insect central synapses: an ultrastructural analysis. Wood, M.R., Pfenninger, K.H., Cohen, M.J. Brain Res. (1977) [Pubmed]
  10. "Cholinergic" postsynaptic membranes of bullfrog sympathetic ganglia: electron microscopy of thin sections and freeze-fracture replicas. Watanabe, H., Washioka, H., Tonosaki, A. Anat. Rec. (1986) [Pubmed]
  11. Structural abnormalities in the stria vascularis following chronic gentamicin treatment. Forge, A., Fradis, M. Hear. Res. (1985) [Pubmed]
  12. Escherichia coli-induced alterations of human spermatozoa. An electron microscopy analysis. Diemer, T., Huwe, P., Michelmann, H.W., Mayer, F., Schiefer, H.G., Weidner, W. Int. J. Androl. (2000) [Pubmed]
  13. Handling Golgi-impregnated tissue for light microscopy. Berbel, P.J., Fairén, A. Neurosci. Lett. (1983) [Pubmed]
  14. Ultramicrotomy of industrial alumina. Antonovsky, A. Microsc. Res. Tech. (1995) [Pubmed]
  15. Uranium-contaminated soils: ultramicrotomy and electron beam analysis. Buck, E.C., Dietz, N.L., Bates, J.K. Microsc. Res. Tech. (1995) [Pubmed]
  16. A correlative study on the topographical distribution of the receptors for low density lipoprotein (LDL) conjugated to colloid gold in cultured human skin fibroblasts employing thin section, freeze-fracture, deep-etching, and surface replication techniques. Robenek, H., Rassat, J., Hesz, A., Grünwald, J. Eur. J. Cell Biol. (1982) [Pubmed]
  17. The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding. Porter, A.E., Hobbs, L.W., Rosen, V.B., Spector, M. Biomaterials (2002) [Pubmed]
  18. A novel approach to AFM characterization of adhesive tooth-biomaterial interfaces. Yoshida, Y., Van Meerbeek, B., Snauwaert, J., Hellemans, L., Lambrechts, P., Vanherle, G., Wakasa, K., Pashley, D.H. J. Biomed. Mater. Res. (1999) [Pubmed]
  19. Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus. Earnest, D.J., DiGiorgio, S., Olschowka, J.A. Brain Res. (1993) [Pubmed]
  20. An ultrastructural study of calcium phosphate formation in multilamellar liposome suspensions. Heywood, B.R., Eanes, E.D. Calcif. Tissue Int. (1987) [Pubmed]
  21. Freeze-etch characterization of the teguments of three metacestodes: Echinococcus granulosus, Taenia crassiceps, and Taenia taeniaeformis. Conder, G.A., Marchiondo, A.A., Williams, J.F., Andersen, F.L. J. Parasitol. (1983) [Pubmed]
  22. Hot knife microtomy for large area sectioning and combined light and electron microscopy in neuroanatomy and neuropathology. McGee-Russell, S.M., De Bruijn, W.C., Gosztonyi, G. J. Neurocytol. (1990) [Pubmed]
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