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Gene Review

SLC7A11  -  solute carrier family 7 (anionic amino...

Homo sapiens

Synonyms: Amino acid transport system xc-, CCBR1, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, Solute carrier family 7 member 11, ...
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Disease relevance of SLC7A11


Psychiatry related information on SLC7A11

  • KSHV target cell permissiveness correlated closely with endogenous expression of xCT messenger RNA and protein in diverse human and nonhuman cell types [6].

High impact information on SLC7A11


Chemical compound and disease context of SLC7A11


Biological context of SLC7A11


Anatomical context of SLC7A11


Associations of SLC7A11 with chemical compounds


Physical interactions of SLC7A11

  • Surprisingly, xCT transport activity in HEK293 cells is not dependent on the co-expression of the exogenous 4F2hc [17].

Other interactions of SLC7A11

  • Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc- [10].

Analytical, diagnostic and therapeutic context of SLC7A11


  1. Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. Bridges, C.C., Hu, H., Miyauchi, S., Siddaramappa, U.N., Ganapathy, M.E., Ignatowicz, L., Maddox, D.M., Smith, S.B., Ganapathy, V. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. RhoA-GTPase Facilitates Entry of Kaposi's Sarcoma-Associated Herpesvirus into Adherent Target Cells in a Src-Dependent Manner. Veettil, M.V., Sharma-Walia, N., Sadagopan, S., Raghu, H., Sivakumar, R., Naranatt, P.P., Chandran, B. J. Virol. (2006) [Pubmed]
  3. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Kanai, Y., Endou, H. Curr. Drug Metab. (2001) [Pubmed]
  4. Expression of the cystine-glutamate exchanger (x(c) (-)) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Dun, Y., Mysona, B., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V., Smith, S.B. Cell Tissue Res. (2006) [Pubmed]
  5. Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. Shih, A.Y., Erb, H., Sun, X., Toda, S., Kalivas, P.W., Murphy, T.H. J. Neurosci. (2006) [Pubmed]
  6. Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. Kaleeba, J.A., Berger, E.A. Science (2006) [Pubmed]
  7. The cystine-glutamate transporter in the accumbens: a novel role in cocaine relapse. Lu, L., Hope, B.T., Shaham, Y. Trends Neurosci. (2004) [Pubmed]
  8. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Huang, Y., Dai, Z., Barbacioru, C., Sadée, W. Cancer Res. (2005) [Pubmed]
  9. Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter. Wang, L., Hinoi, E., Takemori, A., Nakamichi, N., Yoneda, Y. J. Biol. Chem. (2006) [Pubmed]
  10. Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. Bassi, M.T., Gasol, E., Manzoni, M., Pineda, M., Riboni, M., Martín, R., Zorzano, A., Borsani, G., Palacín, M. Pflugers Arch. (2001) [Pubmed]
  11. Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. Sasaki, H., Sato, H., Kuriyama-Matsumura, K., Sato, K., Maebara, K., Wang, H., Tamba, M., Itoh, K., Yamamoto, M., Bannai, S. J. Biol. Chem. (2002) [Pubmed]
  12. Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway. Jiménez-Vidal, M., Gasol, E., Zorzano, A., Nunes, V., Palacín, M., Chillarón, J. J. Biol. Chem. (2004) [Pubmed]
  13. Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility. Gasol, E., Jiménez-Vidal, M., Chillarón, J., Zorzano, A., Palacín, M. J. Biol. Chem. (2004) [Pubmed]
  14. Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. Bridges, C.C., Kekuda, R., Wang, H., Prasad, P.D., Mehta, P., Huang, W., Smith, S.B., Ganapathy, V. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  15. Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells. Ruiz, E., Siow, R.C., Bartlett, S.R., Jenner, A.M., Sato, H., Bannai, S., Mann, G.E. Free Radic. Biol. Med. (2003) [Pubmed]
  16. Expression and function of cystine/glutamate transporter in neutrophils. Sakakura, Y., Sato, H., Shiiya, A., Tamba, M., Sagara, J., Matsuda, M., Okamura, N., Makino, N., Bannai, S. J. Leukoc. Biol. (2007) [Pubmed]
  17. xCt cystine transporter expression in HEK293 cells: pharmacology and localization. Shih, A.Y., Murphy, T.H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  18. Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. Sato, H., Tamba, M., Kuriyama-Matsumura, K., Okuno, S., Bannai, S. Antioxid. Redox Signal. (2000) [Pubmed]
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