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Disease relevance of Jaundice


High impact information on Jaundice

  • The serum cholestanol levels were high even in group I (i.e., in patients without icterus) and increased progressively to group III, up to 6 and 13 times those in group I and the control group, respectively [6].
  • One patient developed increased icterus leading to withdrawal of estradiol [7].
  • This report suggests that plasma cholesterol is diminished by hepatitis prior to the development of icterus [8].
  • IgM antibodies to HAV reached highest concentrations between one and three weeks after onset of icterus and were measurable in follow-up sera for at least 12 months after infection [9].
  • Icterus, lipemia, hemoglobin, or disproteinemia had no effect on the analytical recovery of digoxin [10].

Chemical compound and disease context of Jaundice

  • Corneal icterus resulting from stromal bilirubin deposition [11].
  • Obstructive icterus and even pulmonary infiltration responded successfully to treatment with ursodeoxycholic acid [12].
  • Major side effects of the quinolones included persistent icterus in one patient receiving ofloxacin and psychiatric symptoms in one patient receiving ciprofloxacin [13].
  • Caffeine predose monitoring is adequate up to 46 weeks postconceptional, and caffeine half-life determination is mandatory whenever the trough level is too high or too low, icterus is present, and from 46 to 50 weeks postconception [14].
  • In an infant who suffered from prolonged icterus and hepatocellular dysfunction we detected an increase of citrulline and dibasic amino acids in plasma and urine [15].

Biological context of Jaundice


Anatomical context of Jaundice


Gene context of Jaundice

  • We sequenced 2005 bp of the mitochondrial ND2 and cytochrome b genes from the 25 recognized species of New World orioles (Icterus) [20].
  • These doses preventing death reduced liver icterus scores, serum alanine aminotransferase and aspartate aminotransferase levels, and liver and serum virus titers relative to placebo controls [21].
  • Interference by haemolysis, icterus and lipaemia in assays on the Beckman Synchron CX5 and methods for correction [22].
  • Reduced hepatic icterus, serum oxalic acid transaminase, serum glutamic pyruvic acid transaminase, and recoverable virus titers from livers and sera of infected mice were also seen as a result of ribamidine treatment [23].
  • To decide on the acceptability of a specimen for the measurement of serum CK-MB, troponin I and myoglobin, we investigated the influence of hemolysis, turbidity, and icterus on those tests by adding arbitrarily made interferents [24].

Analytical, diagnostic and therapeutic context of Jaundice


  1. Microencapsulated antibodies in radioimmunoassay. III. Determination of cortisol. Bordens, R.W., Halpern, E.P. Clin. Chem. (1980) [Pubmed]
  2. Inapparent infection of hepatitis A virus. Yang, N.Y., Yu, P.H., Mao, Z.X., Chen, N.L., Chai, S.A., Mao, J.S. Am. J. Epidemiol. (1988) [Pubmed]
  3. Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response. Delwaide, J., Bourgeois, N., Gérard, C., De Maeght, S., Mokaddem, F., Wain, E., Bastens, B., Fevery, J., Géhénot, M., Le Moine, O., Martinet, J.P., Robaeys, G., Servais, B., Van Gossum, M., Van Vlierberghe, H. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  4. Hepatotoxicity with antiretroviral treatment of pregnant women. Hill, J.B., Sheffield, J.S., Zeeman, G.G., Wendel, G.D. Obstetrics and gynecology. (2001) [Pubmed]
  5. Use of hepatobiliary scintigraphy to diagnose bile duct atresia in a lamb. Lofstedt, J., Koblik, P.D., Jakowski, R.M., McMillan, M.C., Engelking, L.R. J. Am. Vet. Med. Assoc. (1988) [Pubmed]
  6. High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation. Nikkilä, K., Höckerstedt, K., Miettinen, T.A. Hepatology (1991) [Pubmed]
  7. Effect of estradiol upon serum enzymes in primary biliary cirrhosis. Guattery, J.M., Faloon, W.W. Hepatology (1987) [Pubmed]
  8. The effect of hepatitis B on plasma cholesterol and sterol balance. Saudek, C.D. Am. J. Med. (1977) [Pubmed]
  9. A solid-phase radioimmunoassay for detection of IgM antibodies to hepatitis A virus. Flehmig, B., Ranke, M., Berthold, H., Gerth, H.J. J. Infect. Dis. (1979) [Pubmed]
  10. Microencapsulated antibodies in radioimmunoassay--I. Determination of digoxin. Halpern, E.P., Bordens, R.W. Clin. Chem. (1979) [Pubmed]
  11. Corneal icterus resulting from stromal bilirubin deposition. Phinney, R.B., Mondino, B.J., Abrahim, A. Ophthalmology (1989) [Pubmed]
  12. Sjögren's syndrome with chronic pancreatitis, sclerosing cholangitis, and pulmonary infiltrations. Nieminen, U., Koivisto, T., Kahri, A., Färkkilä, M. Am. J. Gastroenterol. (1997) [Pubmed]
  13. Infection prophylaxis in neutropenic patients with acute leukaemia--a randomized, comparative study with ofloxacin, ciprofloxacin and co-trimoxazole/colistin. Arning, M., Wolf, H.H., Aul, C., Heyll, A., Scharf, R.E., Scheider, W. J. Antimicrob. Chemother. (1990) [Pubmed]
  14. Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. Le Guennec, J.C., Billon, B., Paré, C. Pediatrics (1985) [Pubmed]
  15. Infantile citrullinemia caused by citrin deficiency with increased dibasic amino acids. Ben-Shalom, E., Kobayashi, K., Shaag, A., Yasuda, T., Gao, H.Z., Saheki, T., Bachmann, C., Elpeleg, O. Mol. Genet. Metab. (2002) [Pubmed]
  16. Challenging diagnosis--icterus associated with a single perforating duodenal ulcer after long-term nonsteroidal antiinflammatory drug administration in a dog. Duerr, F.M., Carr, A.P., Bebchuk, T.N., Pople, N.C. Can. Vet. J. (2004) [Pubmed]
  17. Heinz bodies, methemoglobinemia, and hemolytic anemia induced in rats by 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline. Fort, F.L., Pratt, M.C., Carter, G.W., Lewkowski, J.P., Heyman, I.A., Cusick, P.K., Kesterson, J.W. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1984) [Pubmed]
  18. Erythrocyte damage in newborn babies caused by hyperbilirubinaemia and hypoxia. Oláh, V.A., Csáthy, L., Karmazsin, L. Acta paediatrica Hungarica. (1991) [Pubmed]
  19. Transformation of bilirubin in gastrointestinal tract and its relationship to neonatal icterus. Jirsová, V., Jirsa, M., Miková, M. Czechoslovak medicine. (1982) [Pubmed]
  20. A molecular phylogeny of the New World orioles (Icterus): the importance of dense taxon sampling. Omland, K.E., Lanyon, S.M., Fritz, S.J. Mol. Phylogenet. Evol. (1999) [Pubmed]
  21. Prophylactic and therapeutic activities of 7-thia-8-oxoguanosine against Punta Toro virus infections in mice. Smee, D.F., Huffman, J.H., Gessaman, A.C., Huggins, J.W., Sidwell, R.W. Antiviral Res. (1991) [Pubmed]
  22. Interference by haemolysis, icterus and lipaemia in assays on the Beckman Synchron CX5 and methods for correction. Randall, A.G., Garcia-Webb, P., Beilby, J.P. Ann. Clin. Biochem. (1990) [Pubmed]
  23. Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections. Sidwell, R.W., Huffman, J.H., Barnard, D.L., Pifat, D.Y. Antiviral Res. (1988) [Pubmed]
  24. The influence of hemolysis, turbidity and icterus on the measurements of CK-MB, troponin I and myoglobin. Kwon, H.J., Seo, E.J., Min, K.O. Clin. Chem. Lab. Med. (2003) [Pubmed]
  25. Interference of cerebral near-infrared oximetry in patients with icterus. Madsen, P.L., Skak, C., Rasmussen, A., Secher, N.H. Anesth. Analg. (2000) [Pubmed]
  26. Rapid improvement of icterus and pruritus by the oral administration of colestimide in two cases of drug-induced hepatitis. Tani, M., Hayashi, Y., Okamoto, S., Yokohama, S., Inaba, M., Kubota, H., Nakamura, K. Intern. Med. (2001) [Pubmed]
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