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MeSH Review


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Disease relevance of Reticulocytosis


Psychiatry related information on Reticulocytosis


High impact information on Reticulocytosis


Chemical compound and disease context of Reticulocytosis


Anatomical context of Reticulocytosis


Gene context of Reticulocytosis

  • Neutralisation of endogenous EPO during infection leads to lethal anaemia while timely administration of exogenous EPO rescues mice although reticulocytosis is suppressed in proportion to the parasitemia level [21].
  • Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis [22].
  • The patients with ankyrin gene mutations tended to be more anemic with a higher level of reticulocytosis than those without these mutations [23].
  • Recombinant human erythropoietin induces a delayed increase in reticulocytosis and in soluble transferrin receptor levels [24].
  • The abnormality, ie, a significantly impaired calcium ATPase activity and a parallel marked increase of intracellular calcium levels, was characteristic of the acute hemolytic crisis although unrelated to the attendant reticulocytosis [25].

Analytical, diagnostic and therapeutic context of Reticulocytosis


  1. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Donahue, R.E., Wang, E.A., Stone, D.K., Kamen, R., Wong, G.G., Sehgal, P.K., Nathan, D.G., Clark, S.C. Nature (1986) [Pubmed]
  2. Azathioprine-induced pure red blood cell aplasia. Old, C.W., Flannery, E.P., Grogan, T.M., Stone, W.H., San Antonio, R.P. JAMA (1978) [Pubmed]
  3. Hereditary spherocytosis with normal osmotic fragility after incubation. Is the autohemolysis test really obsolete? Fukagawa, N., Friedman, S., Gill, F.M., Schwartz, E., Shaller, C. JAMA (1979) [Pubmed]
  4. Hereditary nonspherocytic hemolytic anemia due to a new hexokinase variant with reduced stability. Magnani, M., Stocchi, V., Cucchiarini, L., Novelli, G., Lodi, S., Isa, L., Fornaini, G. Blood (1985) [Pubmed]
  5. Primary biliary cirrhosis. A patient with adverse reactions to tiopronin and autoimmune hemolytic anemia with reticulocytopenia. Shichiri, M., Koyama, W., Tozuka, S., Sakamoto, S., Kanayama, M. Arch. Intern. Med. (1984) [Pubmed]
  6. Impaired pentose phosphate shunt function in sickle cell disease: a potential mechanism for increased Heinz body formation and membrane lipid peroxidation. Lachant, N.A., Davidson, W.D., Tanaka, K.R. Am. J. Hematol. (1983) [Pubmed]
  7. Requirement for increased IL-10 in the development of B-1 lymphoproliferative disease in a murine model of CLL. Ramachandra, S., Metcalf, R.A., Fredrickson, T., Marti, G.E., Raveche, E. J. Clin. Invest. (1996) [Pubmed]
  8. Stimulation of erythropoietic differentiation in BALB/c mice infected with Rauscher leukemia virus. Weitz-Hamburger, A., Fredrickson, T.N., LoBue, J., Hardy, W.D., Camiscoli, J.F., Ferdinand, P., Gallicchio, V., Gordon, A.S. J. Natl. Cancer Inst. (1975) [Pubmed]
  9. Evidence that histidine is an essential amino acid in normal and chronically uremic man. Kopple, J.D., Swendseid, M.E. J. Clin. Invest. (1975) [Pubmed]
  10. Inappropriately low reticulocytosis in severe malarial anemia correlates with suppression in the development of late erythroid precursors. Chang, K.H., Tam, M., Stevenson, M.M. Blood (2004) [Pubmed]
  11. Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte. Vigário, A.M., Belnoue, E., Cumano, A., Marussig, M., Miltgen, F., Landau, I., Mazier, D., Gresser, I., Rénia, L. Blood (2001) [Pubmed]
  12. Angiosarcoma with pulmonary siderosis and persistent reticulocytosis. Steroid responsiveness suggests an immune basis. Rajdev, N., Green, R., Crosby, W.H. Arch. Intern. Med. (1978) [Pubmed]
  13. Pure red cell aplasia associated with administration of sustained-release procainamide. Giannone, L., Kugler, J.W., Krantz, S.B. Arch. Intern. Med. (1987) [Pubmed]
  14. Folacin, cobalamin, and hematological status during pregnancy in rural Kenya: the influence of parity, gestation, and Plasmodium falciparum malaria. Brabin, B.J., van den Berg, H., Nijmeyer, F. Am. J. Clin. Nutr. (1986) [Pubmed]
  15. Blood cell flow cytometry in paroxysmal nocturnal hemoglobinuria: a tool for measuring the extent of the PNH clone. Alfinito, F., Del Vecchio, L., Rocco, S., Boccuni, P., Musto, P., Rotoli, B. Leukemia (1996) [Pubmed]
  16. Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes. Kerler, F., Hültner, L., Ziegler, I., Katzenmaier, G., Bacher, A. J. Cell. Physiol. (1990) [Pubmed]
  17. Impaired adenylate cyclase activity of phenylhydrazine-induced reticulocytes. Cooper, D.M., Jagus, R. J. Biol. Chem. (1982) [Pubmed]
  18. Insulin-driven erythropoiesis may underlie impairment of erythrocyte deformability in hyperinsulinaemic, hyperglycaemic ob/ob-mice. Engström, K.G., Grankvist, K., Täljedal, I.B. Diabetologia (1990) [Pubmed]
  19. Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. Nakano, M., Ohneda, K., Yamamoto-Mukai, H., Shimizu, R., Ohneda, O., Ohmura, S., Suzuki, M., Tsukamoto, S., Yanagawa, T., Yoshida, H., Takakuwa, Y., Yamamoto, M. Genes Cells (2005) [Pubmed]
  20. Chloramine-induced haemolysis presenting as erythropoietin resistance. Fluck, S., McKane, W., Cairns, T., Fairchild, V., Lawrence, A., Lee, J., Murray, D., Polpitiye, M., Palmer, A., Taube, D. Nephrol. Dial. Transplant. (1999) [Pubmed]
  21. Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. Chang, K.H., Stevenson, M.M. Int. J. Parasitol. (2004) [Pubmed]
  22. Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis. Chang, K.H., Tam, M., Stevenson, M.M. J. Infect. Dis. (2004) [Pubmed]
  23. Ankyrin gene mutations in japanese patients with hereditary spherocytosis. Nakanishi, H., Kanzaki, A., Yawata, A., Yamada, O., Yawata, Y. Int. J. Hematol. (2001) [Pubmed]
  24. Pharmacokinetic-pharmacodynamic modelling of recombinant human erythropoietin in athletes. Varlet-Marie, E., Gaudard, A., Audran, M., Gomeni, R., Bressolle, F. International journal of sports medicine. (2003) [Pubmed]
  25. Favism: disordered erythrocyte calcium homeostasis. De Flora, A., Benatti, U., Guida, L., Forteleoni, G., Meloni, T. Blood (1985) [Pubmed]
  26. Erythropoietin production by the fetal liver in an adult environment. Flake, A.W., Harrison, M.R., Adzick, N.S., Zanjani, E.D. Blood (1987) [Pubmed]
  27. Subclinical hemolytic disease of the newborn due to anti-e. Hanzlick, R.L., Senhauser, D.A. Am. J. Clin. Pathol. (1979) [Pubmed]
  28. The effects of maternal phlebotomy and orally-administered erythropoietin (Ep) on erythropoiesis in the suckling rat. Carmichael, R.D., Gordon, A.S., LoBue, J. Biol. Neonate (1978) [Pubmed]
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