Disease relevance of Developmental Disabilities

• Fragile X syndrome (fraX) is the most common known cause of inherited developmental disability. fraX is associated with a CGG expansion in the FMR1 gene on the long arm of the X chromosome [1].
• Heterozygous carriers of an ataxia-telangiectasia (A-T), Fanconi anemia (FA), or xeroderma pigmentosum (XP) gene may be predisposed to some of the same congenital malformations or developmental disabilities that are common among homozygotes [2].
• We reflect on the proceedings of a symposium at a conference of the Centers for Disease Control and Prevention National Center on Birth Defects and Developmental Disabilities [3].
• Movement disorders in children with developmental disabilities taking risperidone [4].
• Prevalence of epilepsy and epileptic seizures in 10-year-old children: results from the Metropolitan Atlanta Developmental Disabilities Study [5].

Psychiatry related information on Developmental Disabilities

• Mental retardation and developmental disabilities influenced by environmental neurotoxic insults [6].
• Melatonin for treatment of sleep disorders in children with developmental disabilities [7].
• To assess the clinical impact of microcephaly among children with developmental disabilities, we reviewed the charts of 1393 consecutive patients from birth to 5 years of age referred to our child development center [8].
• Dana and Rick, two adults with developmental disabilities enrolled in a restaurant training program, had poor prospects for long-term employment because of inappropriate social behavior [9].
• This study examined the psychometric properties of the Matson Evaluation of Social Skills for Individuals with Severe Retardation (MESSIER)--a new scale designed to measure social skills in adults with severe developmental disabilities [10].

High impact information on Developmental Disabilities

• Brain dysfunction is the most important sequelae of the fragile X (FMR-1) mutation, the most common heritable cause of developmental disability [11].
• The outcome is poor in children who survive prolonged neonatal hyperammonemic coma, with most manifesting developmental disabilities [12].
• We describe the investigation and control of a community-acquired outbreak of MRSA skin infections in a closed community of institutionalized adults with developmental disabilities [13].
• This patient had a subsequent history of poor compliance with pyridoxine therapy and severe developmental disability [14].
• Although both children showed developmental disabilities, the degree of cognitive delay was significantly less than that described in previous reports of children with Joubert syndrome [15].

Chemical compound and disease context of Developmental Disabilities

• METHOD: A retrospective longitudinal analysis was performed for a sample of 41 adults with developmental disabilities and comorbid psychiatric and/or behavioral syndromes for whom treatment was converted from typical antipsychotics to olanzapine or risperidone for a minimum period of 2 years [16].
• Does methylmercury have a role in causing developmental disabilities in children [17]?
• Review of fenfluramine in the treatment of the developmental disabilities [18].
• To determine if maternal toluene abuse produces any structural or developmental disabilities in the developing fetus, a cohort of toluene-exposed infants was ascertained and examined [19].
• OBJECTIVE: This was a double-blind, placebo-controlled, crossover design study of the safety and efficacy of methylphenidate (MPH) in 11 preschool children (aged 4.0-5.11 years) with developmental disabilities and attention-deficit hyperactivity disorder (ADHD) [20].

Biological context of Developmental Disabilities

• The number of trinucleotide repeats in the 5' untranslated regions of the FMR1 and FMR2 genes was determined by PCR in 254 Fragile XA-negative Javanese male children with developmental disabilities [21].
• The human PCLO gene maps to 7q11.23-q21.3, a region of chromosome 7 implicated as a linkage site for autism and Williams Syndrome suggesting that alterations in the expression of Piccolo or the PCLO gene could contribute to developmental disabilities and mental retardation [22].
• Apart from the annual general assembly, the Society's main activities include the publication of two official journals--"No To Hattatsu" and "Brain & Development" both bimonthly--the sponsorship of postgraduate seminars on child neurology every year and the organization of International Symposia on Developmental Disabilities on a biennial bases [23].

Gene context of Developmental Disabilities

• Like the symptoms of a developmental disability, the symptoms of ADHD must be evaluated in the context of age-based norms; therefore, the current criteria for ADHD, which are not age referenced, may minimize the rate of persistence of ADHD into adulthood [24].
• Fragile X syndrome is the most common form of inherited mental retardation currently known, associated with a wide range of developmental disabilities in both males and females, caused by a large expansion of a (CGG)n repeat in the first exon of the FMR1 gene [25].
• BACKGROUND: Velocardiofacial syndrome (VCFS) is a common microdeletion syndrome associated with psychiatric morbidity and developmental disabilities [26].
• Epilepsy and developmental disabilities (DD) often occur together but affect individuals differently and have a complex causal relationship [27].
• There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum alpha-fetoprotein [28].

Analytical, diagnostic and therapeutic context of Developmental Disabilities

• We compared the efficacy and safety of diazepam rectal gel to IV lorazepam in our long-term care facility for adults with developmental disabilities [29].
• Epilepsy is a significant comorbid condition in institutionalized persons with developmental disabilities and may contribute significant additional costs [30].
• Our results emphasize the importance of a structured approach to these problems, and we propose a diagnostic and treatment algorithm for children with developmental disabilities and suspected feeding disorders.children, developmental disabilities, fundoplication, gastroesophageal reflux, gastrostomy, hospitalization, nutrition [31].

References