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Chemical Compound Review

Hibiclens     2-[N'-[6-[[amino-[[amino- [(4...

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Disease relevance of Hibiclens

  • The aim of the present study was to evaluate the effect of TNP-470, an anti-angiogenic compound, on the development of peritoneal fibrosis induced by chlorhexidine gluconate (CG) [1].
  • Three commercial sanitizers containing iodophor (I), peracetic acid/ hydrogen peroxide (PAH), or chlorhexidine gluconate (CG) were evaluated in vitro against planktonic and sessile Bacillus subtilis or Pseudomonas fluorescens cells grown in Standard One Nutrient Broth [2].
  • Peridex was the most effective in inhibiting plaque and gingivitis formation over that period of time [3].
  • Hibiclens keratitis and the TCA masque: reply [4].
  • Colitis after Hibiclens enema [5].

High impact information on Hibiclens

  • Immunoreactivity for endogenous endostatin (whole molecule) and endostatin receptor alpha5beta1-integrin was increased and colocalized to CD31(+) blood vessels in the thickened peritonea of CG-injected mice [6].
  • RESULTS: CG-injected mice showed thickening of the submesothelial zone and increased number of vessels, myofibroblasts, and infiltrating macrophages [1].
  • METHODS: Peritoneal fibrosis was induced by injection of CG into peritoneal cavity of Institute for Cancer Research (ICR) mice [1].
  • Treatment with antisense ODNs, but not sense ODNs, abrogated CG-induced changes in the expression of HSP47, type I and III collagen, alpha-SMA, and the number of infiltrating macrophages and vessels [7].
  • RESULTS: Mice receiving peritoneal infusions of CHG saline every other day for 2 weeks developed increasing numbers of FSP1+ fibroblasts in the subserosal layers of the visceral peritoneum [8].

Chemical compound and disease context of Hibiclens


Biological context of Hibiclens

  • BACKGROUND: Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming [13].
  • Measures taken to hamper the spread included contact precautions throughout the unit, cleansing and disinfection of equipment and surfaces, bathing children with 2% chlorhexidine-gluconate-containing soap, professional reeducation, and reinforcement of all measures to prevent infections [14].

Anatomical context of Hibiclens

  • There were no significant differences in numbers of colony-forming units between participants in the CHG or ALC group at any time period [15].
  • The aim of this study was to examine the changes in the cultivable microflora of carious dentin before and after atraumatic restorative treatment (ART) and investigate the inhibitory effect of chlorhexidine-gluconate-based cavity disinfectant in the microflora [16].
  • The expression of HSP-47 was evident in mesothelial cells and submesothelial connective tissue after day 7 of treatment with CG, and increased thereafter [17].
  • Over a 3-year period, 371 patients (total of 654 impacted mandibular third molars) received either no treatment (group 1), 2 weeks of twice daily Peridex rinse postsurgery (group 2), or one rinse presurgery (group 3) [18].
  • We used peridex, composed of chlorhexidine for antiseptic treatment of oral cavity [19].

Associations of Hibiclens with other chemical compounds


Gene context of Hibiclens

  • On the other hand, in the CHG group, expression of AQP-1 and AQP-4 were significantly suppressed, and ultrafiltration volume was lost [25].
  • On the stain intensity index there was a significant statistical difference on buccal surfaces between Crest and Rembrandt with placebo compared to Crest with Peridex [26].

Analytical, diagnostic and therapeutic context of Hibiclens

  • Male ICR mice received intraperitoneal injections of chlorhexidine gluconate (CG) every other day to induce peritoneal sclerosis [6].
  • After four hours of gloving on both days 1 and 5, microbial counts on hands of subjects using ALC, TRI and CHG were significantly lower than counts for the control (p less than .001), whereas there was no significant difference in counts between the PI and control groups (p = .41) [27].
  • The interview also addressed awareness of skin care issues involving the compatibility of moisturizers with latex gloves and handwashing agents that contain CHG [20].
  • On the basis of a crossover study design, a plain soap and one containing 4% chlorhexidine gluconate (CHG) were used alternatively in each ward for 4 consecutive months [28].
  • From 12 patients assigned to the test group rinsing 2 x daily with 15 ml of 0.12% CHX solution (Peridex) starting 2 days after tooth extraction and from 11 patients assigned to the control group rinsing with a placebo solution, standardized radiographs were available taken immediately after tooth extraction and 1, 2, 3 and 6 months thereafter [29].


  1. TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. Yoshio, Y., Miyazaki, M., Abe, K., Nishino, T., Furusu, A., Mizuta, Y., Harada, T., Ozono, Y., Koji, T., Kohno, S. Kidney Int. (2004) [Pubmed]
  2. Different responses of planktonic and attached Bacillus subtilis and Pseudomonas fluorescens to sanitizer treatment. Lindsay, D., von Holy, A. J. Food Prot. (1999) [Pubmed]
  3. Efficacy on supragingival plaque control of cetylpyridinium chloride in a slow-release dosage form. Vandekerckhove, B.N., Van Steenberghe, D., Tricio, J., Rosenberg, D., Encarnacion, M. Journal of clinical periodontology. (1995) [Pubmed]
  4. Hibiclens keratitis and the TCA masque: reply. Resnik, B.I., Resnik, S.S., Chiarello, S. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1997) [Pubmed]
  5. Colitis after Hibiclens enema. Hardin, R.D., Tedesco, F.J. J. Clin. Gastroenterol. (1986) [Pubmed]
  6. Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model. Tanabe, K., Maeshima, Y., Ichinose, K., Kitayama, H., Takazawa, Y., Hirokoshi, K., Kinomura, M., Sugiyama, H., Makino, H. Kidney Int. (2007) [Pubmed]
  7. Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats. Nishino, T., Miyazaki, M., Abe, K., Furusu, A., Mishima, Y., Harada, T., Ozono, Y., Koji, T., Kohno, S. Kidney Int. (2003) [Pubmed]
  8. Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome. Okada, H., Inoue, T., Kanno, Y., Kobayashi, T., Watanabe, Y., Ban, S., Neilson, E.G., Suzuki, H. Kidney Int. (2003) [Pubmed]
  9. In vitro activity of chlorhexidine against enteric rods, pseudomonads and acinetobacter from human periodontitis. Slots, J., Rams, T.E., Schonfeld, S.E. Oral Microbiol. Immunol. (1991) [Pubmed]
  10. The effect of 3 mouthrinses on plaque and gingivitis development. Maruniak, J., Clark, W.B., Walker, C.B., Magnusson, I., Marks, R.G., Taylor, M., Clouser, B. Journal of clinical periodontology. (1992) [Pubmed]
  11. The antimicrobial activity in vitro of chlorhexidine, a mixture of isothiazolinones ('Kathon' CG) and cetyl trimethyl ammonium bromide (CTAB). Nicoletti, G., Boghossian, V., Gurevitch, F., Borland, R., Morgenroth, P. J. Hosp. Infect. (1993) [Pubmed]
  12. Review of disinfectant susceptibility of bacteria isolated in hospital to commonly used disinfectants. Shiraishi, T., Nakagawa, Y. Postgraduate medical journal. (1993) [Pubmed]
  13. Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application. Hobson, D.W., Woller, W., Anderson, L., Guthery, E. American journal of infection control. (1998) [Pubmed]
  14. Clustering of Enterococcus faecalis infections in a cardiology hospital neonatal intensive care unit. Strabelli, T.M., Cais, D.P., Zeigler, R., Siciliano, R., Rodrigues, C., Carrara, D., Neres, S., Lessa, S., Uip, D.E. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. (2006) [Pubmed]
  15. Assessment of two hand hygiene regimens for intensive care unit personnel. Larson, E.L., Aiello, A.E., Bastyr, J., Lyle, C., Stahl, J., Cronquist, A., Lai, L., Della-Latta, P. Crit. Care Med. (2001) [Pubmed]
  16. Inhibition of cultivable bacteria by chlorhexidine treatment of dentin lesions treated with the ART technique. Ersin, N.K., Uzel, A., Aykut, A., Candan, U., Eronat, C. Caries Res. (2006) [Pubmed]
  17. Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis. Mishima, Y., Miyazaki, M., Abe, K., Ozono, Y., Shioshita, K., Xia, Z., Harada, T., Taguchi, T., Koji, T., Kohno, S. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2003) [Pubmed]
  18. Effect of chlorhexidine rinse on the incidence of dry socket in impacted mandibular third molar extraction sites. Bonine, F.L. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1995) [Pubmed]
  19. Comprehensive treatment of generalized parodontitis. Mdinaradze, N. Georgian medical news. (2006) [Pubmed]
  20. Washington State hospital survey 2000: gloves, handwashing agents, and moisturizers. Marino, C., Cohen, M. American journal of infection control. (2001) [Pubmed]
  21. Comparison of the immediate, residual, and cumulative antibacterial effects of Novaderm R,* Novascrub R,* Betadine Surgical Scrub, Hibiclens, and liquid soap. Faoagali, J., Fong, J., George, N., Mahoney, P., O'Rourke, V. American journal of infection control. (1995) [Pubmed]
  22. Antiseptic vs. saline lavage in purulent and faecal peritonitis. Vallance, S., Waldron, R. J. Hosp. Infect. (1985) [Pubmed]
  23. Clinical effects of a 0.12% chlorhexidine rinse as an adjunct to scaling and root planing. Beiswanger, B.B., Mallat, M.E., Jackson, R.D., Mau, M.S., Farah, C.F., Bosma, M.L., Bollmer, B.W., Hancock, E.B. The Journal of clinical dentistry. (1992) [Pubmed]
  24. Laboratory evaluation of anti-biofilm agents for use in dental unit waterlines. Meiller, T.F., Kelley, J.I., Baqui, A.A., DePaola, L.G. The Journal of clinical dentistry. (2001) [Pubmed]
  25. Glucocorticoid restores the deterioration of water transport in the peritoneum through increment in aquaporin. Imai, H., Nakamoto, H., Ishida, Y., Inoue, T., Kanno, Y., Okada, H., Suzuki, S., Okano, H., Suzuki, H. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (2000) [Pubmed]
  26. Rembrandt toothpaste stain prevention with and without the use of Peridex. Emling, R.C., Levin, S., Shi, X., Weinberg, S., Yankell, S.L. The Journal of clinical dentistry. (1992) [Pubmed]
  27. Alcohol for surgical scrubbing? Larson, E.L., Butz, A.M., Gullette, D.L., Laughon, B.A. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1990) [Pubmed]
  28. Assessment of handwashing practices with chemical and microbiologic methods: preliminary results from a prospective crossover study. Marena, C., Lodola, L., Zecca, M., Bulgheroni, A., Carretto, E., Maserati, R., Zambianchi, L. American journal of infection control. (2002) [Pubmed]
  29. Effect of chlorhexidine (0.12%) rinses on periodontal tissue healing after tooth extraction. (II). Radiographic parameters. Brägger, U., Schild, U., Lang, N.P. Journal of clinical periodontology. (1994) [Pubmed]
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