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MeSH Review

Fractures, Open

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Disease relevance of Fractures, Open


High impact information on Fractures, Open

  • METHODS: Adult patients with an open fracture of the lower extremity were prospectively randomized to receive irrigation with either a bacitracin solution or a nonsterile castile soap solution [3].
  • In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment [4].
  • The patients were randomized to one of the two single-dose cephalosporin regimens and by operative procedure groups that included hysterectomies, genitourinary procedures, gastrointestinal operations, and the "other procedures" category that was dominated by orthopedic cases, such as total joint replacements and open fracture reductions [5].
  • The apparent lack of deep preferential pathways for TCE migration, such as open fractures, is probably due to the softness of the silty aquitard deposit and minimal physical or chemical weathering of the aquitard [6].
  • Low-temperature calcite and opal record the past seepage of water into open fractures and lithophysal cavities in the unsaturated zone at Yucca Mountain, Nevada, site of a proposed high-level radioactive waste repository [7].

Chemical compound and disease context of Fractures, Open


Anatomical context of Fractures, Open

  • Immediate consultation should be obtained with nerve or vascular damage, fracture-dislocation injuries, open fractures, substantial skin loss, or flexor tendon injuries at or distal to the wrist [13].

Gene context of Fractures, Open

  • The clinical usefulness of C-reactive protein (CRP) and of transthyretin (TTR) for the early diagnosis and follow-up of infection after an open fracture was prospectively investigated (cohort A) [14].
  • The use of the Vidal-Adrey external fixation system. Part 1: The treatment of open fractures [15].
  • There is well-documented evidence justifying, perhaps demanding, the obligatory use of early, anticipatory treatment in open fractures and in penetrating abdominal wounds, and equally convincing evidence that they are not indicated in fractures of the base of the skull with CSF leaks, in thermal injuries, or in simple lacerations [16].
  • From October 1976 till May 1978 we treated 39 open shank fractures; 24 of them were 2nd and 3rd degree open fractures [17].
  • In Banda Aceh, the surgical procedures that we could do were limited to external fixation of open fractures and debriding infected wounds at the Indonesian Red Crescent field hospital [18].

Analytical, diagnostic and therapeutic context of Fractures, Open


  1. Reduced sensitivity to beta-lactam antibiotics arising during ceftazidime treatment of Pseudomonas aeruginosa infections. King, A., Shannon, K., Eykyn, S., Phillips, I. J. Antimicrob. Chemother. (1983) [Pubmed]
  2. Use of antibiotic-loaded polymethyl methacrylate beads in the management of musculoskeletal sepsis--a retrospective study. Mohanty, S.P., Kumar, M.N., Murthy, N.S. Journal of orthopaedic surgery (Hong Kong) (2003) [Pubmed]
  3. Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study. Anglen, J.O. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  4. Duration of preventive antibiotic administration for open extremity fractures. Dellinger, E.P., Caplan, E.S., Weaver, L.D., Wertz, M.J., Droppert, B.M., Hoyt, N., Brumback, R., Burgess, A., Poka, A., Benirschke, S.K. Archives of surgery (Chicago, Ill. : 1960) (1988) [Pubmed]
  5. Single-dose cephalosporin prophylaxis of 929 surgical procedures in a prepaid group practice: a prospective, randomized comparison of cefoperazone and cefotaxime. Jones, R.N., Wojeski, W.V. Diagn. Microbiol. Infect. Dis. (1987) [Pubmed]
  6. Field study of TCE diffusion profiles below DNAPL to assess aquitard integrity. Parker, B.L., Cherry, J.A., Chapman, S.W. J. Contam. Hydrol. (2004) [Pubmed]
  7. Estimation of past seepage volumes from calcite distribution in the Topopah Spring Tuff, Yucca Mountain, Nevada. Marshall, B.D., Neymark, L.A., Peterman, Z.E. J. Contam. Hydrol. (2003) [Pubmed]
  8. Once daily, high dose versus divided, low dose gentamicin for open fractures. Sorger, J.I., Kirk, P.G., Ruhnke, C.J., Bjornson, S.H., Levy, M.S., Cockrin, J., Tang, P. Clin. Orthop. Relat. Res. (1999) [Pubmed]
  9. Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. Patzakis, M.J., Bains, R.S., Lee, J., Shepherd, L., Singer, G., Ressler, R., Harvey, F., Holtom, P. Journal of orthopaedic trauma. (2000) [Pubmed]
  10. A double-blind clinical trial of prophylactic cloxacillin in open fractures. Braun, R., Enzler, M.A., Rittmann, W.W. Journal of orthopaedic trauma. (1987) [Pubmed]
  11. Cephradine and flucloxacillin in the prophylaxis of infection in patients with open fractures. Alpar, E.K. Journal of clinical pharmacy and therapeutics. (1988) [Pubmed]
  12. Delayed local treatment of rabbit tibial fractures with biodegradable cefazolin microspheres. Jacob, E., Cierny, G., Zorn, K., McNeill, J.F., Fallon, M.T. Clin. Orthop. Relat. Res. (1997) [Pubmed]
  13. Emergency management of hand injuries. When to repair, when to refer. Sturm, J.T., Cicero, J.J. Postgraduate medicine. (1986) [Pubmed]
  14. C-reactive protein to transthyretin ratio for the early diagnosis and follow-up of postoperative infection. Férard, G., Gaudias, J., Bourguignat, A., Ingenbleek, Y. Clin. Chem. Lab. Med. (2002) [Pubmed]
  15. The use of the Vidal-Adrey external fixation system. Part 1: The treatment of open fractures. Krempen, J.F., Silver, R.A., Sotelo, A. Clin. Orthop. Relat. Res. (1979) [Pubmed]
  16. Prophylactic antibiotics in traumatic wounds. Sacks, T. J. Hosp. Infect. (1988) [Pubmed]
  17. External fixation as an alternative when treating 2nd and 3rd degree open lower leg fractures. Schöntag, H., Schöttle, H., Jungbluth, K.H. Archives of orthopaedic and traumatic surgery. Archiv für orthopädische und Unfall-Chirurgie. (1980) [Pubmed]
  18. The Malaysian Orthopaedic Association humanitarian mission to Indonesia and Sri Lanka. Sharaf, I., Saw, A., Hyzan, Y., Sivananthan, K.S. Med. J. Malaysia (2005) [Pubmed]
  19. The prophylactic use of antibiotic impregnated beads in open fractures. Henry, S.L., Ostermann, P.A., Seligson, D. The Journal of trauma. (1990) [Pubmed]
  20. A survey, in Scotland, of measures to prevent infection following orthopaedic surgery. Wilson, N.I. J. Hosp. Infect. (1987) [Pubmed]
  21. Open fractures of the forearm in children. Greenbaum, B., Zionts, L.E., Ebramzadeh, E. Journal of orthopaedic trauma. (2001) [Pubmed]
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