Disease relevance of Osteochondritis

• In contrast, C3c and C9 deposits were not found in chronic conditions associated with degenerative diseases (osteoarthritis and osteochondritis dissecans) or mechanical causes (patellar luxation and a ruptured meniscus), in which also the protectin expression was prominent in synovial lining, endothelial and some stromal cells [1].
• Chondrocalcinosis, defined as radiopaque deposits in the joint cartilages and in semilunar cartilages of the knee joint, develops frequently in patients in whom osteochondritis dissecans is diagnosed after the epiphyseal line of the distal end of the femur is closed [2].
• Gadopentetate-dimeglumine-enhanced MR imaging of osteonecrosis and osteochondritis dissecans of the elbow: initial experience [3].
• Pathology of the os trigonum-talar process is the most common cause of this syndrome, but it also may result from flexor hallucis longus tenosynovitis, ankle osteochondritis, subtalar joint disease, and fracture [4].
• Sixteen patients had posttraumatic degenerative joint disease, three patients suffered from a previous infection, four patients had rheumatoid arthritis, and three patients had an osteochondritis dissecans in their past history [5].

High impact information on Osteochondritis

• Family study of inherited syndrome with multiple congenital deformities: symphalangism, carpal and tarsal fusion, brachydactyly, craniosynostosis, strabismus, hip osteochondritis [6].
• BACKGROUND: Optimal treatment of osteochondritis dissecans of the knee is still controversial [7].
• METHODS: A total of 14 patients (15 knees) with osteochondritis dissecans of the knee were treated with arthroscopic titanium Herbert screw fixation of the osteochondral fragment [7].
• Juvenile osteochondritis dissecans of the lateral femoral condyle after lateral discoid meniscal surgery [8].
• The results identify differential alterations in aggrecan and type-II collagen turnover in the cartilage matrix in young animals with osteochondrosis that may contribute to the pathological degeneration of articular cartilage in this disease [9].

Chemical compound and disease context of Osteochondritis

• In young horses with osteochondrosis, there was a significant increase of C-propeptide of type-II procollagen accompanied by a decrease in the 846 and keratan sulfate epitopes [9].
• Activation of the complement system and adverse effects of biodegradable pins of polylactic acid (Biofix) in osteochondritis dissecans [10].
• It was concluded that the development of osteochondrosis is associated with increased exposure to zinc and possibly cadmium [11].
• Strontium-85 uptake in knee joints with osteochondritis dissecans [12].
• Multinucleate cells and mononucleate cells with dense cytoplasm and a delicate periphery were seen in smears from cases with clinical diagnoses of osteochondrosis or fracture; interpretation of these cells as osteoclasts and their mononucleate precursors was supported by positive staining with tartrate-resistant acid phosphatase [13].

Anatomical context of Osteochondritis

• We used immunoassays that measure a keratan sulfate epitope and the epitope 846 on the cartilage proteoglycan aggrecan and the C-propeptide of cartilage type-II procollagen, which is released following the synthesis of this molecule, to analyse synovial fluids from equine tarsocrural joints with and without osteochondrosis [9].
• PURPOSE: The purpose of this study was to describe the clinical presentation of 6 athletically active children with symptomatic osteochondritis dissecans (OCD) of the lateral femoral condyle following total resection for a torn discoid lateral meniscus and to discuss its cause [14].
• Demonstration of osteochondritis dissecans of the talus by coronal computed tomographic arthrography [15].

Gene context of Osteochondritis

• Familial polyarticular osteochondritis dissecans masquerading as juvenile rheumatoid arthritis [16].
• It has been suggested that osteochondrosis is the underlying cause of osteochondritis dissecans in humans [17].
• Familial osteochondritis dissecans and carpal tunnel syndrome [18].

Analytical, diagnostic and therapeutic context of Osteochondritis

• Direct coronal computed tomography arthrography of osteochondritis dissecans of the talus [19].
• We describe using a core harvester, the Osteochondral Autograft Transfer System (OATS; Arthrex, Naples, Fla), to remove a Herbert-Whipple screw placed earlier in a failed attempt to fix an osteochondritis dissecans lesion on the lateral aspect of the medial femoral condyle [20].

References