The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Cxcl11  -  chemokine (C-X-C motif) ligand 11

Mus musculus

Synonyms: C-X-C motif chemokine 11, Cxc11, H174, I-TAC, I-tac, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cxcl11


Psychiatry related information on Cxcl11

  • Moreover, food deprivation led to a greater increase in hypothalamic mOX2 beta R gene expression, compared with both mOX1R and mOX2 alpha R. This potentially implicates a fundamental physiological role for these splice variants [5].

High impact information on Cxcl11

  • In this study, we addressed the role of type I IFNs by examining the infection of L. monocytogenes in BALB/c mice lacking the type I IFN receptor (IFN-alpha/betaR-/-) [6].
  • Resistance was correlated with elevated levels of interleukin 12p70 in the blood and increased numbers of CD11b+ macrophages producing tumor necrosis factor alpha in the spleen of IFN-alpha/betaR-/- mice [6].
  • In addition, the intracellular fate of L. monocytogenes in macrophages cultured from IFN-alpha/betaR-/- and wild-type mice was indistinguishable [6].
  • Particularly striking was restoration of near-normal trigeminal ganglion replication and neurovirulence of an ICP34.5 mutant in IFN-alpha/betaR-/- mice [4].
  • Anti-LT-beta-R mAbs were also identified that inhibited ligand-induced cell death, whereas others were found to potentiate the activity of the ligand when added in solution [7].

Biological context of Cxcl11

  • Taken together, these studies suggest that IP-10, MIG, I-TAC, and CXCR3 interactions are involved in mucosal immune responses required for the induction of CD [8].
  • Monokine-induced by IFN-gamma (MIG), IFN-gamma-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10), are chemokines that bind CXCR3 and mediate the chemotaxis of leukocytes [8].
  • The nucleotide sequence of Scyb11 shares 63% identity with its human counterpart [9].
  • Using a BAC clone containing Scyb11, this gene could be mapped to chromosome 5 at position 5E3 [9].
  • A genomic sequence was obtained by genome walking and subcloning DNA fragments from a BAC clone containing Scyb11 [9].

Anatomical context of Cxcl11


Associations of Cxcl11 with chemical compounds

  • Here, we cloned the cDNA of the murine homologue of this protein, Scyb11, from interferon-gamma/lipopolysaccharide-stimulated RAW264.7 mouse macrophage-like cells [9].
  • Intron 1 of Scyb11 is also characterized by a 201-bp stretch with repetitive sequences of high cryptic simplicity [9].
  • The action of core 2 GlcNAc-transferase followed by beta 1-4Gal-transferase provides an N-acetyllactosamine antenna that can be extended with polylactosamine (i.e. repeating Gal beta 1-4GlcNAc beta 1-3) provided UDP-GlcNAc:Gal beta-R beta 1-3GlcNAc-transferase (GlcNAc-transferase) (i)) activity is present [14].
  • The angiogenic activity in the lung was significantly decreased, however, and CXCL11 treatment reduced the total number of endothelial cells in the lung following bleomycin exposure [15].
  • However, a single administration of CORT to adrenalectomized mice significantly decreased the mRNA levels of IFN-alpha/beta R1 in the liver [16].

Regulatory relationships of Cxcl11


Other interactions of Cxcl11

  • 2. Recently, we identified mouse Scyb11 and mapped this gene by fluorescence in situ hybridization (FISH) to mouse Chr 5E3, the orthologous locus to human 4q21 where the other two homologous mouse genes, Scyb9 and Scyb10, have also been localized [18].
  • In vivo trafficking assays demonstrated a requirement for IFN-alpha/betaR signaling for leukocyte localization in, and delivery of MIP-1alpha-producing macrophages to, the liver [19].
  • To identify novel mechanisms involved in combating intracellular infections, experiments were performed in mice with selective defects in the lymphotoxin (LT)/LT beta R pathway [20].
  • IRF-7 and IRF-9 gene expression was increased in LCMV-infected brain from IFN-gamma knockout (KO) but not IFN-alpha/betaR KO animals [21].
  • Overnight treatment of 32D/PDGF-beta R/PKC-delta cells with PDGF-BB induced monocytic differentiation as judged by an increase in expression of cell surface macrophage differentiation markers [22].

Analytical, diagnostic and therapeutic context of Cxcl11


  1. A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo. Hamilton, N.H., Mahalingam, S., Banyer, J.L., Ramshaw, I.A., Thomson, S.A. Scand. J. Immunol. (2004) [Pubmed]
  2. The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions. Flier, J., Boorsma, D.M., Bruynzeel, D.P., Van Beek, P.J., Stoof, T.J., Scheper, R.J., Willemze, R., Tensen, C.P. J. Invest. Dermatol. (1999) [Pubmed]
  3. The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8+ T lymphocytes but not inhibition of angiogenesis. Hensbergen, P.J., Wijnands, P.G., Schreurs, M.W., Scheper, R.J., Willemze, R., Tensen, C.P. J. Immunother. (2005) [Pubmed]
  4. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. Leib, D.A., Harrison, T.E., Laslo, K.M., Machalek, M.A., Moorman, N.J., Virgin, H.W. J. Exp. Med. (1999) [Pubmed]
  5. Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. Chen, J., Randeva, H.S. Mol. Endocrinol. (2004) [Pubmed]
  6. Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. Auerbuch, V., Brockstedt, D.G., Meyer-Morse, N., O'Riordan, M., Portnoy, D.A. J. Exp. Med. (2004) [Pubmed]
  7. Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines. Browning, J.L., Miatkowski, K., Sizing, I., Griffiths, D., Zafari, M., Benjamin, C.D., Meier, W., Mackay, F. J. Exp. Med. (1996) [Pubmed]
  8. IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. Singh, U.P., Singh, S., Iqbal, N., Weaver, C.T., McGhee, J.R., Lillard, J.W. J. Interferon Cytokine Res. (2003) [Pubmed]
  9. Cloning, genomic sequence, and chromosome mapping of Scyb11, the murine homologue of SCYB11 (alias betaR1/H174/SCYB9B/I-TAC/IP-9/CXCL11). Meyer, M., Erdel, M., Duba, H.C., Werner, E.R., Werner-Felmayer, G. Cytogenet. Cell Genet. (2000) [Pubmed]
  10. The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant) is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia. Widney, D.P., Xia, Y.R., Lusis, A.J., Smith, J.B. J. Immunol. (2000) [Pubmed]
  11. PDGF and its receptors in the developing rodent retina and optic nerve. Mudhar, H.S., Pollock, R.A., Wang, C., Stiles, C.D., Richardson, W.D. Development (1993) [Pubmed]
  12. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. Barton, E.S., Lutzke, M.L., Rochford, R., Virgin, H.W. J. Virol. (2005) [Pubmed]
  13. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. Samuel, M.A., Diamond, M.S. J. Virol. (2005) [Pubmed]
  14. Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis. Yousefi, S., Higgins, E., Daoling, Z., Pollex-Krüger, A., Hindsgaul, O., Dennis, J.W. J. Biol. Chem. (1991) [Pubmed]
  15. CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling. Burdick, M.D., Murray, L.A., Keane, M.P., Xue, Y.Y., Zisman, D.A., Belperio, J.A., Strieter, R.M. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  16. Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. Koyanagi, S., Suyama, H., Kuramoto, Y., Matsunaga, N., Takane, H., Soeda, S., Shimeno, H., Higuchi, S., Ohdo, S. Endocrinology (2006) [Pubmed]
  17. IFN-gamma regulates murine interferon-inducible T cell alpha chemokine (I-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis (EAE). Hamilton, N.H., Banyer, J.L., Hapel, A.J., Mahalingam, S., Ramsay, A.J., Ramshaw, I.A., Thomson, S.A. Scand. J. Immunol. (2002) [Pubmed]
  18. High-resolution mapping of the human 4q21 and the mouse 5E3 SCYB chemokine cluster by fiber-fluorescence in situ hybridization. Erdel, M., Theurl, M., Meyer, M., Duba, H.C., Utermann, G., Werner-Felmayer, G. Immunogenetics (2001) [Pubmed]
  19. Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver. Salazar-Mather, T.P., Lewis, C.A., Biron, C.A. J. Clin. Invest. (2002) [Pubmed]
  20. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. Ehlers, S., Hölscher, C., Scheu, S., Tertilt, C., Hehlgans, T., Suwinski, J., Endres, R., Pfeffer, K. J. Immunol. (2003) [Pubmed]
  21. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. Ousman, S.S., Wang, J., Campbell, I.L. J. Virol. (2005) [Pubmed]
  22. Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta. Li, W., Yu, J.C., Michieli, P., Beeler, J.F., Ellmore, N., Heidaran, M.A., Pierce, J.H. Mol. Cell. Biol. (1994) [Pubmed]
  23. Allelic exclusion of a T cell receptor-beta minilocus. van Meerwijk, J.P., Iglesias, A., Hansen-Hagge, T., Bluethmann, H., Steinmetz, M. J. Immunol. (1991) [Pubmed]
WikiGenes - Universities