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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Optical Rotation

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Disease relevance of Optical Rotation


High impact information on Optical Rotation


Biological context of Optical Rotation


Anatomical context of Optical Rotation

  • We have discussed the nature of a scleral lens that will allow us to follow changes in aqueous humor glucose levels in animals by a method based on optical rotation and a technique described in an earlier paper [12].

Associations of Optical Rotation with chemical compounds


Gene context of Optical Rotation

  • An analysis of the data gave the difference in free energy between the low- and high-energy conformers as 1315 cal/mol and gave the optical rotation of the low-energy conformer and the average of the rotations of the higher energy forms [18].
  • The reaction conditions were mild and there was no acyl migration, as shown by optical rotation of the monoacyl-sn-glycerols [19].
  • Regeneration of ribonuclease A from the reduced protein. 1. Conformational analysis of the intermediates by measurements of enzymatic activity, optical density, and optical rotation [20].
  • Intrinsic viscosity and optical rotation data obtained on hemoglobin and myoglobin at high salt concentrations, above the unfolding transition regions, indicate that the product of denaturation by the aliphatic acid salts is less unfolded than in 6 M guanidine hydrochloride solutions [21].
  • Furthermore, a racemic sample of N-acylated hexafluoroleucine was enzymatically resolved by treatment with porcine kidney acylase I and was found to have the same optical rotation as a synthetic sample of 6 [22].

Analytical, diagnostic and therapeutic context of Optical Rotation


  1. Salmonella typhimurium neuraminidase acts with inversion of configuration. Guo, X., Sinnott, M.L. Biochem. J. (1993) [Pubmed]
  2. Polarimetric assay for the medium-throughput determination of alpha-amino acid racemase activity. Schönfeld, D.L., Bornscheuer, U.T. Anal. Chem. (2004) [Pubmed]
  3. Structures of the O-specific polysaccharide chains of Pectinatus cerevisiiphilus and Pectinatus frisingensis lipopolysaccharides. Senchenkova, S.N., Shashkov, A.S., Moran, A.P., Helander, I.M., Knirel, Y.A. Eur. J. Biochem. (1995) [Pubmed]
  4. Ammodendrine and N-methylammodendrine enantiomers: isolation, optical rotation, and toxicity. Lee, S.T., Molyneux, R.J., Panter, K.E., Chang, C.W., Gardner, D.R., Pfister, J.A., Garrossian, M. J. Nat. Prod. (2005) [Pubmed]
  5. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Pollick, C., Giacomini, K.M., Blaschke, T.F., Nelson, W.L., Turner-Tamiyasu, K., Briskin, V., Popp, R.L. Circulation (1982) [Pubmed]
  6. Activation of a cryptic gene encoding a kinase for L-xylulose opens a new pathway for the utilization of L-lyxose by Escherichia coli. Sánchez, J.C., Gímenez, R., Schneider, A., Fessner, W.D., Baldomà, L., Aguilar, J., Badía, J. J. Biol. Chem. (1994) [Pubmed]
  7. Archaea contain a novel diether phosphoglycolipid with a polar head group identical to the conserved core of eucaryal glycosyl phosphatidylinositol. Nishihara, M., Utagawa, M., Akutsu, H., Koga, Y. J. Biol. Chem. (1992) [Pubmed]
  8. Properties of aspartate racemase, a pyridoxal 5'-phosphate-independent amino acid racemase. Yamauchi, T., Choi, S.Y., Okada, H., Yohda, M., Kumagai, H., Esaki, N., Soda, K. J. Biol. Chem. (1992) [Pubmed]
  9. Structural heterogeneity among unique sulfated L-galactans from different species of ascidians (tunicates). Pavão, M.S., Albano, R.M., Lawson, A.M., Mourão, P.A. J. Biol. Chem. (1989) [Pubmed]
  10. Immunochemical and structural characterization of the antigenic polysaccharide from Eubacterium saburreum T18. Nakazawa, F., Hoshino, E. Oral Microbiol. Immunol. (1992) [Pubmed]
  11. Synthesis of O-glycosylated tuftsins by utilizing threonine derivatives containing an unprotected monosaccharide moiety. Filira, F., Biondi, L., Cavaggion, F., Scolaro, B., Rocchi, R. Int. J. Pept. Protein Res. (1990) [Pubmed]
  12. Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens. March, W.F., Rabinovitch, B., Adams, R.L. Diabetes Care (1982) [Pubmed]
  13. Chemical structure of the galactomannan from the cell wall of Aspergillus niger. Bardalaye, P.C., Nordin, J.H. J. Biol. Chem. (1977) [Pubmed]
  14. Stereochemical course of the adenosine triphosphate phosphoribosyltransferase reaction in histidine biosynthesis. Chelsky, D., Parsons, S.M. J. Biol. Chem. (1975) [Pubmed]
  15. Complex formation between mycobacterial polysaccharides or cyclodextrins and palmitoyl coenzyme A. Bergeron, R., Machida, Y., Bloch, K. J. Biol. Chem. (1975) [Pubmed]
  16. Coupled cluster and density functional theory studies of the vibrational contribution to the optical rotation of (S)-propylene oxide. Kongsted, J., Pedersen, T.B., Jensen, L., Hansen, A.E., Mikkelsen, K.V. J. Am. Chem. Soc. (2006) [Pubmed]
  17. Stability and melting kinetics of structural domains in the myosin rod. Tsong, T.Y., Himmelfarb, S., Harrington, W.F. J. Mol. Biol. (1983) [Pubmed]
  18. Conformational effects on optical rotation. 3-substituted 1-butenes. Wiberg, K.B., Vaccaro, P.H., Cheeseman, J.R. J. Am. Chem. Soc. (2003) [Pubmed]
  19. Improved method for the synthesis of 1- or 3-acyl-sn-glycerols. Kodali, D.R. J. Lipid Res. (1987) [Pubmed]
  20. Regeneration of ribonuclease A from the reduced protein. 1. Conformational analysis of the intermediates by measurements of enzymatic activity, optical density, and optical rotation. Konishi, Y., Scheraga, H.A. Biochemistry (1980) [Pubmed]
  21. Effects of the aliphatic carboxylate series of salts on the conformation of proteins. Ibanez, V.S., Herskovits, T.T. Biochemistry (1976) [Pubmed]
  22. A novel synthesis of enantiomerically pure 5,5,5,5',5',5'-hexafluoroleucine. Xing, X., Fichera, A., Kumar, K. Org. Lett. (2001) [Pubmed]
  23. Cell-wall lipopolysaccharide of the 'Shigella-like' Escherichia coli 0124. Structure of the polysaccharide chain. Dmitriev, B.A., Lvov, V.L., Kochetkov, N.K., Jann, B., Jann, K. Eur. J. Biochem. (1976) [Pubmed]
  24. Analysis of chiral pharmaceuticals using HPLC with CD detection. Jenkins, A.L., Hedgepeth, W.A. Chirality. (2005) [Pubmed]
  25. An NMR and circular dichroism study of the interaction of thiocyanate with human and cross-linked hemoglobin: identification of Lys-alpha-99 as a possible dissociation linked binding site. Sau, A.K., Currell, D., Mazumdar, S., Mitra, S. Biophys. Chem. (2003) [Pubmed]
  26. A novel enzymatic approach to the massproduction of L-galactose from L-sorbose. Leang, K., Maekawa, K., Menavuvu, B.T., Morimoto, K., Granström, T.B., Takada, G., Izumori, K. J. Biosci. Bioeng. (2004) [Pubmed]
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