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MeSH Review

Mouth Floor

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Disease relevance of Mouth Floor


High impact information on Mouth Floor

  • One hundred and forty nine patients with carcinoma of the tongue or floor of mouth were treated with interstitial irradiation (+/- external beam therapy) using caesium needles or iridium wires between 1970 and 1986 [6].
  • The purpose of this study was to determine the benefit of our 10-year follow-up program in patients with stage I and II squamous cell carcinoma (SCC) of the floor of mouth and tongue [7].
  • An immunohistochemical analysis of 32 cases of oral squamous cell carcinoma (eight in the inferior lip, eight in the lateral angle of the tongue, eight in the palate and eight in the mouth floor) was performed to evaluate the expression pattern of c-erbB-2 protein and S-100-positive cells in the lesions [8].
  • MRI with or without gadopentetate dimeglumine (Gd-DTPA)-enhancement in seven lesions of the sublingual regions was performed [9].
  • METHOD: Archival paraffin sections from 48 oral squamous cell carcinomas (SCC) (23 floor of mouth, 25 tongue) and 56 oesophageal carcinomas (41 SCC, 15 adenocarcinomas) were evaluated for hTR expression using a radiolabelled riboprobe [10].

Chemical compound and disease context of Mouth Floor


Biological context of Mouth Floor


Anatomical context of Mouth Floor


Associations of Mouth Floor with chemical compounds


Gene context of Mouth Floor

  • The diagnostic information content of currently applied imaging protocols for sestamibi in SCC of the mouth floor is not affected by tumor-specific properties [20].
  • Sonography of the tongue and floor of mouth. Part I: Anatomy [21].
  • Three types of reconstruction (skin grafts, hemitongue flaps, and myocutaneous flaps) and results of a series of tests given to 15 surgical patients with T2 and T3 tongue and/or floor of mouth lesions were evaluated [22].
  • Over a 15-year period, 251 patients with cancer of the floor of mouth were seen and treated at Roswell Park Memorial Institute. Of this group, 34 patients underwent a marginal mandibular resection as part of their curative surgical treatment [23].
  • CONCLUSIONS: An abnormal airway was significantly more likely after a high-velocity injury, and when the tongue, floor of mouth, midline or bilateral facial skeletal bones were involved [24].

Analytical, diagnostic and therapeutic context of Mouth Floor

  • METHODS: In a longitudinal cohort study involving 102 patients who were treated with curative intent for a pT1-2N0M0 SCC of the floor of mouth and tongue from 1989-1998 with a minimum follow-up of 5 years, we evaluated the effect of routine follow-up [7].
  • Twenty-three patients with squamous cell carcinoma (SCC) of the mouth floor who were scheduled for surgery were imaged 5 min. p.i. with a triple-head gamma camera (360 degrees, 3 degrees/step SPECT, UHRPAR collimators) [20].
  • Using an in vivo orthotopic floor-of-mouth xenograft model, locoregional tumor invasion of SCC-1 into muscle, vessel, bone, and perineural tissues was inhibited in C225-treated mice [25].


  1. Iridium-192 curietherapy for T1 and T2 epidermoid carcinomas of the floor of mouth. Mazeron, J.J., Grimard, L., Raynal, M., Haddad, E., Piedbois, P., Martin, M., Marinello, G., Nair, R.C., Le Bourgeois, J.P., Pierquin, B. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  2. Short-term chloral hydrate administration and cancer in humans. Haselkorn, T., Whittemore, A.S., Udaltsova, N., Friedman, G.D. Drug safety : an international journal of medical toxicology and drug experience. (2006) [Pubmed]
  3. Use of the CO2 laser for malignant disease of the oral cavity. Duncavage, J.A., Ossoff, R.H. Lasers in surgery and medicine. (1986) [Pubmed]
  4. Prognostic staging system for recurrent, persistent, and second primary cancers of the oral cavity and oropharynx. Yueh, B., Feinstein, A.R., Weaver, E.M., Sasaki, C.T., Concato, J. Arch. Otolaryngol. Head Neck Surg. (1998) [Pubmed]
  5. The midline sagittal glossotomy for treatment of dermoid cysts of the mouth floor. Brusati, R., Galioto, S., Tullio, A., Moscato, G. J. Oral Maxillofac. Surg. (1991) [Pubmed]
  6. Interstitial irradiation for carcinoma of the tongue and floor of mouth: Royal Marsden Hospital Experience 1970-1986. Dearnaley, D.P., Dardoufas, C., A'Hearn, R.P., Henk, J.M. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1991) [Pubmed]
  7. Effectiveness of routine follow-up of patients treated for T1-2N0 oral squamous cell carcinomas of the floor of mouth and tongue. Merkx, M.A., van Gulick, J.J., Marres, H.A., Kaanders, J.H., Bruaset, I., Verbeek, A., de Wilde, P.C. Head & neck. (2006) [Pubmed]
  8. Correlation of c-erbB-2 and S-100 expression with the malignancy grading and anatomical site in oral squamous cell carcinoma. Albuquerque, R.L., Miguel, M.C., Costa, A.L., Souza, L.B. International journal of experimental pathology. (2003) [Pubmed]
  9. Assessment of carcinoma in the sublingual region based on magnetic resonance imaging. Asaumi, J., Shigehara, H., Konouchi, H., Yanagi, Y., Hisatomi, M., Matsuzaki, H., Kishi, K. Oncol. Rep. (2002) [Pubmed]
  10. Expression of telomerase RNA in oesophageal and oral cancer. Downey, M.G., Going, J.J., Stuart, R.C., Keith, W.N. J. Oral Pathol. Med. (2001) [Pubmed]
  11. Squamous cell carcinoma of tongue and floor of mouth associated with syndrome of inappropriate secretion of antidiuretic hormone. Okutomi, T., Sakata, S., Tatematsu, N., Oka, N. J. Oral Maxillofac. Surg. (1987) [Pubmed]
  12. Aspects of cell proliferation in oral epithelial dysplastic lesions. Oliver, R.J., MacDonald, D.G., Felix, D.H. J. Oral Pathol. Med. (2000) [Pubmed]
  13. Enhanced penetration of nitrosonornicotine across oral mucosa in the presence of ethanol. Squier, C.A., Cox, P., Hall, B.K. J. Oral Pathol. (1986) [Pubmed]
  14. Patterns of care outcome survey: national outcome data for six disease sites. Hanks, G.E., Kramer, S., Diamond, J.J., Herring, D.F. Am. J. Clin. Oncol. (1982) [Pubmed]
  15. Overexpression of the Wilms' tumor gene WT1 in head and neck squamous cell carcinoma. Oji, Y., Inohara, H., Nakazawa, M., Nakano, Y., Akahani, S., Nakatsuka, S., Koga, S., Ikeba, A., Abeno, S., Honjo, Y., Yamamoto, Y., Iwai, S., Yoshida, K., Oka, Y., Ogawa, H., Yoshida, J., Aozasa, K., Kubo, T., Sugiyama, H. Cancer Sci. (2003) [Pubmed]
  16. Carcinoma of the floor of the mouth. Nakissa, N., Hornback, N.B., Shidnia, H., Sayoc, E. Cancer (1978) [Pubmed]
  17. Iridium-192 implantation for T1 and T2a carcinoma of the tongue and floor of mouth: retrospective study of the results of treatment at the Royal Berkshire Hospital. Wadsley, J.C., Patel, M., Tomlins, C.D., Gildersleve, J.Q. The British journal of radiology. (2003) [Pubmed]
  18. Androgen receptors and antiandrogen therapy for laryngeal carcinoma. Mattox, D.E., Von Hoff, D.D., McGuire, W.L. Archives of otolaryngology (Chicago, Ill. : 1960) (1984) [Pubmed]
  19. Carcinoma of the tongue and floor of the mouth. Preliminary results of a multidisciplinary approach. Airoldi, M., Fazio, M., Gandolfo, S., Ozzello, F., Pedani, F. Journal of maxillofacial surgery. (1985) [Pubmed]
  20. Is early sestamibi imaging in head and neck cancer affected by MDR status, p53 expression, or cell proliferation? Leitha, T., Glaser, C., Lang, S. Nucl. Med. Biol. (1998) [Pubmed]
  21. Sonography of the tongue and floor of mouth. Part I: Anatomy. Neuhold, A., Frühwald, F., Balogh, B., Wicke, L. European journal of radiology. (1986) [Pubmed]
  22. A comparison of three methods of oral reconstruction. McConnel, F.M., Teichgraeber, J.F., Adler, R.K. Arch. Otolaryngol. Head Neck Surg. (1987) [Pubmed]
  23. Mandible preservation in the treatment of cancer of the floor of the mouth. Beecroft, W.A., Sako, K., Razack, M.S., Shedd, D.P. Journal of surgical oncology. (1982) [Pubmed]
  24. Airway status in civilian maxillofacial gunshot injuries in Johannesburg, South Africa. Tsakiris, P., Cleaton-Jones, P.E., Lownie, M.A. S. Afr. Med. J. (2002) [Pubmed]
  25. Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade. Huang, S.M., Li, J., Harari, P.M. Mol. Cancer Ther. (2002) [Pubmed]
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