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Chemical Compound Review

Iron nitrosyl     azanylidyneoxidanium; iron

Synonyms: AR-1K9496, AC1L3X2P, A836723, iron; nitrilooxonium, dinitrosyl iron complex, ...
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Disease relevance of dinitrosyl iron complex


High impact information on dinitrosyl iron complex

  • In the third model, mitochondria lost preformed iron-nitrosyl complexes when exposed to blood [4].
  • RESULTS: Iron-nitrosyl complexes and hepatocyte mitochondrial dysfunction were observed in the in vitro model and prevented by an NO synthase inhibitor [4].
  • Here, we discuss some recent studies focusing on iron nutrition in plants as well as evidence from iron homeostasis in animals and propose a new scenario involving the formation of nitric oxide and iron-nitrosyl complexes as part of the dynamic network that governs plant iron homeostasis [5].
  • EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages [6].
  • K562 cells did not produce any appreciable levels of NO, but they were targeted by RNIs released from the cytokine-stimulated vascular cells, as demonstrated by electron paramagnetic resonance spectrometry, which showed formation of nonheme iron-nitrosyl complexes in the tumor cells [7].

Chemical compound and disease context of dinitrosyl iron complex


Biological context of dinitrosyl iron complex


Anatomical context of dinitrosyl iron complex


Associations of dinitrosyl iron complex with other chemical compounds


Gene context of dinitrosyl iron complex

  • Hepatocytes exposed to IFN-gamma, TNF-alpha, IL-1 beta, and LPS demonstrated the appearance of a g = 2.04 axial EPR signal indicative of the formation of nonheme iron-nitrosyl complexes [18].
  • A key factor in the inhibitory effect of IL-1 beta and TNF in rat islets is the generation of nitric oxide which inactivates enzymes such as aconitase and ribonucleotide reductase by formation of iron-nitrosyl complexes [19].
  • These findings suggest specifically N-nitrosation of glutathione reductase as a likely mechanism of inhibition elicited by dinitrosyl-iron complex and demonstrate in general that structural resemblance of an NO carrier with a natural ligand enhances NO+ transfer to the ligand-binding protein [20].
  • The use of several spectroscopic tools such as EPR, ENDOR, FTIR, Mössbauer, and UV-visible spectroscopies as well as mass spectrometry analysis was necessary to characterize the iron-nitrosyl species in Fur [21].
  • Earlier studies showed that the characterization of iron binding to BFR could be aided by EPR analysis of iron-nitrosyl species resulting from the addition of NO to the protein [Le Brun, Cheesman, Andrews, Harrison, Guest, Moore and Thomson (1993) FEBS Lett. 323, 261-266] [16].

Analytical, diagnostic and therapeutic context of dinitrosyl iron complex

  • In contrast, in allografts on POD4, a new axial signal at g = 2.04 and g = 2.02 appeared that was attributed to the dinitrosyl-iron complex formed by nitrosylation of non-heme protein [22].
  • A novel cyclic tetra-nuclear dinitrosyl iron complex [Fe(NO)2(Im-H)]4 was isolated and characterized by X-ray crystallography, and in donor solvents this fragments into 17 e- monomeric units that give EPR spectra analogous to the g= 2.03 species seen in mammalian biology [23].
  • Simultaneously DNIC enhanced the resistance of isolated heart and the organism as a whole to damaging effects of intracellular calcium overload induced by post-ischemic reperfusion or vigorous exercise, respectively [11].


  1. L-cysteine-mediated destabilization of dinitrosyl iron complexes in proteins. Rogers, P.A., Ding, H. J. Biol. Chem. (2001) [Pubmed]
  2. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. Lancaster, J.R., Langrehr, J.M., Bergonia, H.A., Murase, N., Simmons, R.L., Hoffman, R.A. J. Biol. Chem. (1992) [Pubmed]
  3. NO-dependent mechanisms of adaptation to hypoxia. Malyshev, I.Y., Zenina, T.A., Golubeva, L.Y., Saltykova, V.A., Manukhina, E.B., Mikoyan, V.D., Kubrina, L.N., Vanin, A.F. Nitric Oxide (1999) [Pubmed]
  4. Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo. Fisch, C., Robin, M.A., Letteron, P., Fromenty, B., Berson, A., Renault, S., Chachaty, C., Pessayre, D. Gastroenterology (1996) [Pubmed]
  5. Nitric oxide and iron in plants: an emerging and converging story. Graziano, M., Lamattina, L. Trends Plant Sci. (2005) [Pubmed]
  6. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Lancaster, J.R., Hibbs, J.B. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha. Geng, Y.J., Hellstrand, K., Wennmalm, A., Hansson, G.K. Cancer Res. (1996) [Pubmed]
  8. Repair of nitric oxide-modified ferredoxin [2Fe-2S] cluster by cysteine desulfurase (IscS). Yang, W., Rogers, P.A., Ding, H. J. Biol. Chem. (2002) [Pubmed]
  9. S-nitrosation of serum albumin by dinitrosyl-iron complex. Boese, M., Mordvintcev, P.I., Vanin, A.F., Busse, R., Mülsch, A. J. Biol. Chem. (1995) [Pubmed]
  10. The relation between sphingomyelinase activity, lipid peroxide oxidation and NO-releasing in mice liver and brain. Alessenko, A.V., Shupik, M.A., Bugrova, A.E., Dudnik, L.B., Shingarova, L.N., Mikoyan, A., Vanin, A.F. FEBS Lett. (2005) [Pubmed]
  11. Nitric oxide increases gene expression of Ca(2+)-ATPase in myocardial and skeletal muscle sarcoplasmic reticulum: physiological implications. Malyshev, I.Y., Aymasheva, N.P., Malenyuk, E.B., Manukhina, E.B., Khaspekov, G.L., Mikoyan, V.D., Kubrina, L.N., Vanin, A.F. Med. Sci. Monit. (2000) [Pubmed]
  12. Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. Corbett, J.A., Lancaster, J.R., Sweetland, M.A., McDaniel, M.L. J. Biol. Chem. (1991) [Pubmed]
  13. Coinduction of nitric oxide synthesis and intracellular nonheme iron-nitrosyl complexes in murine cytokine-treated fibroblasts. Lancaster, J.R., Werner-Felmayer, G., Wachter, H. Free Radic. Biol. Med. (1994) [Pubmed]
  14. Bioactivation of nitroprusside by porcine endothelial cells. Rochelle, L.G., Kruszyna, H., Kruszyna, R., Barchowsky, A., Wilcox, D.E., Smith, R.P. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  15. The origin of dinitrosyl-iron complex in endothelial cells. Komarov, A.M., Mak, I.T., Weglicki, W.B. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  16. Interaction of nitric oxide with non-haem iron sites of Escherichia coli bacterioferritin: reduction of nitric oxide to nitrous oxide and oxidation of iron(II) to iron(III). Le Brun, N.E., Andrews, S.C., Moore, G.R., Thomson, A.J. Biochem. J. (1997) [Pubmed]
  17. The mechanisms of S-nitrosothiol decomposition catalyzed by iron. Vanin, A.F., Papina, A.A., Serezhenkov, V.A., Koppenol, W.H. Nitric Oxide (2004) [Pubmed]
  18. Nonheme iron-nitrosyl complex formation in rat hepatocytes: detection by electron paramagnetic resonance spectroscopy. Stadler, J., Bergonia, H.A., Di Silvio, M., Sweetland, M.A., Billiar, T.R., Simmons, R.L., Lancaster, J.R. Arch. Biochem. Biophys. (1993) [Pubmed]
  19. Cytokines, nitric oxide and insulin secreting cells. Cunningham, J.M., Green, I.C. Growth Regul. (1994) [Pubmed]
  20. Inhibition of glutathione reductase by dinitrosyl-iron-dithiolate complex. Boese, M., Keese, M.A., Becker, K., Busse, R., Mülsch, A. J. Biol. Chem. (1997) [Pubmed]
  21. Spectroscopic description of the two nitrosyl-iron complexes responsible for fur inhibition by nitric oxide. D'Autréaux, B., Horner, O., Oddou, J.L., Jeandey, C., Gambarelli, S., Berthomieu, C., Latour, J.M., Michaud-Soret, I. J. Am. Chem. Soc. (2004) [Pubmed]
  22. Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Pieper, G.M., Halligan, N.L., Hilton, G., Konorev, E.A., Felix, C.C., Roza, A.M., Adams, M.B., Griffith, O.W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. A cyclic tetra-nuclear dinitrosyl iron complex [Fe(NO)2(imidazolate)]4: synthesis, structure and stability. Wang, X., Sundberg, E.B., Li, L., Kantardjieff, K.A., Herron, S.R., Lim, M., Ford, P.C. Chem. Commun. (Camb.) (2005) [Pubmed]
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