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Chemical Compound Review

Wellcovorin     calcium(2S)-2-[[4-[(2-amino- 5-methanoyl-4...

Synonyms: Lederfoline, Prestwick_224, CHEMBL1201138, CCG-38930, Uzel (TN), ...
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Disease relevance of leucovorin


High impact information on leucovorin


Chemical compound and disease context of leucovorin


Biological context of leucovorin


Anatomical context of leucovorin


Associations of leucovorin with other chemical compounds


Gene context of leucovorin

  • Twenty six patients with pleural mesothelioma of UICC stage I-IV excluding M1 disease (46% of whom had stage I disease and 38% stage III disease) were treated intravenously with high dose MTX (3 g) and calcium folinate rescue three times at intervals of 2 weeks and three times at intervals of 3 weeks [26].

Analytical, diagnostic and therapeutic context of leucovorin


  1. Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Madajewicz, S., Petrelli, N., Rustum, Y.M., Campbell, J., Herrera, L., Mittelman, A., Perry, A., Creaven, P.J. Cancer Res. (1984) [Pubmed]
  2. Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection. Sirotnak, F.M., Schmid, F.A., DeGraw, J.I. Cancer Res. (1989) [Pubmed]
  3. Effective initial therapy of advanced breast cancer with fluorouracil and high-dose, continuous infusion calcium leucovorin. Margolin, K.A., Doroshow, J.H., Akman, S.A., Leong, L.A., Morgan, R.J., Raschko, J.W., Somlo, G., Blevins, C. J. Clin. Oncol. (1992) [Pubmed]
  4. Phase I and pharmacokinetic study of recombinant human granulocyte-macrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma. Grem, J.L., McAtee, N., Murphy, R.F., Hamilton, J.M., Balis, F., Steinberg, S., Arbuck, S.G., Setser, A., Jordan, E., Chen, A. J. Clin. Oncol. (1994) [Pubmed]
  5. The use of alternate, non-cross-resistant adjuvant chemotherapy on the basis of pathologic response to a neoadjuvant doxorubicin-based regimen in women with operable breast cancer: long-term results from a prospective randomized trial. Thomas, E., Holmes, F.A., Smith, T.L., Buzdar, A.U., Frye, D.K., Fraschini, G., Singletary, S.E., Theriault, R.L., McNeese, M.D., Ames, F., Walters, R., Hortobagyi, G.N. J. Clin. Oncol. (2004) [Pubmed]
  6. Phase I trial of intraperitoneal iododeoxyuridine with and without intravenous high-dose folinic acid in the treatment of advanced malignancies primarily confined to the peritoneal cavity: flow cytometric and pharmacokinetic analysis. Morgan, R.J., Newman, E.M., Doroshow, J.H., McGonigle, K., Margolin, K., Raschko, J., Chow, W., Somlo, G., Leong, L., Tetef, M., Shibata, S., Hamasaki, V., Carroll, M., Vasilev, S., Akman, S., Coluzzi, P., Wagman, L., Longmate, J., Paz, B., Yen, Y., Klevecz, R. Cancer Res. (1998) [Pubmed]
  7. Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis. Mehta, B.M., Glass, J.P., Shapiro, W.R. Cancer Res. (1983) [Pubmed]
  8. Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model. Sirotnak, F.M., Donsbach, R.C., Moccio, D.M., Dorick, D.M. Cancer Res. (1976) [Pubmed]
  9. Leucovorin in combination chemotherapy of breast cancer. Corder, M.P., Sheets, R.F., Stone, W.H., Flannery, E.P., Justice, G.R., Herbst, K.D. Clin. Pharmacol. Ther. (1977) [Pubmed]
  10. Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia. Fulton, B., Wagstaff, A.J., McTavish, D. Drugs (1995) [Pubmed]
  11. Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced hepatocellular carcinoma. Mani, S., Schiano, T., Garcia, J.C., Ansari, R.H., Samuels, B., Sciortino, D.F., Tembe, S., Shulman, K.L., Baker, A., Benner, S.E., Vokes, E.E. Investigational new drugs. (1998) [Pubmed]
  12. High-dose methotrexate for non-AIDS primary central nervous system lymphoma. Report of 13 cases. Gabbai, A.A., Hochberg, F.H., Linggood, R.M., Bashir, R., Hotleman, K. J. Neurosurg. (1989) [Pubmed]
  13. Salvage chemotherapy for advanced Hodgkin's disease. Garbes, I.D., Gomez, G.A., Han, T., Henderson, E.S. Med. Pediatr. Oncol. (1987) [Pubmed]
  14. Oxaliplatin: a review of its use in the management of metastatic colorectal cancer. Wiseman, L.R., Adkins, J.C., Plosker, G.L., Goa, K.L. Drugs & aging. (1999) [Pubmed]
  15. Transient encephalopathy during the late course of treatment with high-dose methotrexate. Fritsch, G., Urban, C. Cancer (1984) [Pubmed]
  16. Pharmacokinetic and pharmacodynamic comparison of two doses of calcium folinate combined with continuous fluorouracil infusion in patients with advanced colorectal cancer. Stremetzne, S., Streit, M., Kreuser, E.D., Schunack, W., Jaehde, U. Pharmacy world & science : PWS. (1999) [Pubmed]
  17. The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Studenberg, S.D., Woolley, J.L., Deangelis, D.V., Wargin, W.A. Biopharmaceutics & drug disposition. (1997) [Pubmed]
  18. Disposition of 5-formyl- and 5-methyltetrahydrofolic acid in serum after i.v. bolus of calcium folinate: pharmacokinetic drug interaction with preadministered interferon-alpha-2b. Czejka, M.J., Schüller, J., Weiss, C., Bandak, S., Meyer, B., Simon, D. European journal of drug metabolism and pharmacokinetics. (1995) [Pubmed]
  19. Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate. Browman, G.P., Booker, L., Spiegl, P. Cancer Chemother. Pharmacol. (1985) [Pubmed]
  20. Use of the 13C-sucrose breath test to assess chemotherapy-induced small intestinal mucositis in the rat. Clarke, J.M., Pelton, N.C., Bajka, B.H., Howarth, G.S., Read, L.C., Butler, R.N. Cancer Biol. Ther. (2006) [Pubmed]
  21. A phase II survival comparison of patients with adenocarcinoma of the pancreas treated with 5-fluorouracil and calcium leucovorin versus a matched tumor registry control population. Weinerman, B.H., MacCormick, R.E. Am. J. Clin. Oncol. (1994) [Pubmed]
  22. The influence of calcium leucovorin on the co-trimoxazole induced inhibition of leukocyte regeneration after bone marrow transplantation in mice. Heidt, P.J., Kieskamp, M.J., Timmermans, C.P. Prog. Clin. Biol. Res. (1985) [Pubmed]
  23. Outcome of rectal and sigmoid carcinoma patients receiving adjuvant chemoradiotherapy in Marmara University Hospital. Yumuk, P.F., Abacioglu, U., Caglar, H., Gumus, M., Sengoz, M., Turhal, N.S. Journal of chemotherapy (Florence, Italy) (2003) [Pubmed]
  24. Oral Xeloda plus bi-platinu two-way combined chemotherapy in treatment of advanced gastrointestinal malignancies. Fan, L., Liu, W.C., Zhang, Y.J., Ren, J., Pan, B.R., Liu, D.H., Chen, Y., Yu, Z.C. World J. Gastroenterol. (2005) [Pubmed]
  25. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Lundell, K., Qazi, S., Eddy, L., Uckun, F.M. Arzneimittel-Forschung. (2006) [Pubmed]
  26. High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma. Halme, M., Knuuttila, A., Vehmas, T., Tammilehto, L., Mäntylä, M., Salo, J., Mattson, K. Br. J. Cancer (1999) [Pubmed]
  27. LC-MS characterization of trace impurities contained in calcium folinate. Francese, G., Corana, F., Meneghetti, O., Marazza, F. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  28. Influence of high-dose leucovorin and 5-fluorouracil chemotherapy regimen on P wave duration and dispersion. Ceyhan, C., Meydan, N., Barutca, S., Tekten, T., Onbasili, A.O., Ozturk, B., Unal, S., Bayrak, I. Journal of clinical pharmacy and therapeutics. (2004) [Pubmed]
  29. Paclitaxel and UFT plus oral calcium folinate in pretreated metastatic breast cancer. Klaassen, U., Borquez, D., Lang, S., Oberhoff, C., Harstrick, A., Seeber, S., Benner, S. Oncology (Williston Park, N.Y.) (1999) [Pubmed]
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