Disease relevance of p-Chlorodiphenyl

• A meta cleavage pathway for 4-chlorobenzoate, an intermediate in the metabolism of 4-chlorobiphenyl by Pseudomonas cepacia P166 [1].
• Identification of a catabolic transposon, Tn4371, carrying biphenyl and 4-chlorobiphenyl degradation genes in Alcaligenes eutrophus A5 [2].
• Resting-cell suspensions of genetically engineered E. coli in mineral salts medium (pH 7.0) containing 880 microM 4-chlorobiphenyl produced 110 microM DHCB [3].
• Effect of 4-chlorobiphenyl on substrate transport and phospholipid metabolism in mouse L5178Y lymphoma cells [4].
• The biodegradation products of 4-chlorobiphenyl were analyzed in an Achromobacter sp. strain and a Bacillus brevis strain [5].

High impact information on p-Chlorodiphenyl

• Microsomes contained high oxidative activities for known cytochrome (Cyt) P450 substrates (fatty acids, cinnamic acid, 3- and 4-chlorobiphenyl, 2, 3-dichlorobiphenyl, and isoproturon; up to 54 pkat/mg protein) [6].
• In vitro metabolism of 4-chlorobiphenyl by control and induced rat liver microsomes [7].
• 4-Chlorobiphenyl (PCB 3), PCB 28, and PCB 153 treatment of Sprague-Dawley rats resulted in a large increase in protein binding to a consensus activated protein-1 (AP-1) element [8].
• Pseudomonas cepacia P166 utilizes 4-chlorobiphenyl for growth and produces 4-chlorobenzoate as a central intermediate [1].
• In curing and conjugation experiments, the A5 endogenous 51-kb IncP1 plasmid pSS50 was found to be dispensable for biphenyl and 4-chlorobiphenyl catabolism [2].

Chemical compound and disease context of p-Chlorodiphenyl

• This study demonstrates that the 4-chlorobiphenyl-degrading Alcaligenes sp. strain ALP83 can degrade 4-chlorobenzoate to 4-hydroxybenzoate [9].
• The effect of vitamins on the aerobic degradation and dechlorination of 2-chlorophenol and 4-chlorophenol by Pseudomonas pickettii, strain LD1, and 4-chlorobiphenyl by Pseudomonas sp. strain CPE1 was determined [10].
• The reporter fusion plasmids were introduced into E. coli XL1-Blue, and the transformant reporters examined for the production of fluorescent light by exposure to aromatic compounds, such as biphenyl, 4-chlorobiphenyl, 4-hydroxybiphenyl, 2,3-dihydroxybiphenyl, catechol and 4-chlorocatechol [11].

Biological context of p-Chlorodiphenyl

• Characteristics and restriction analysis of the 4-chlorobiphenyl catabolic plasmid, pSS50 [12].
• Novel biotransformations of 4-chlorobiphenyl by a Pseudomonas sp [13].
• Rates of total mineralization of 4-chlorobiphenyl (at 39 to 385 micrograms ml-1 levels) were dependent on substrate concentration, whereas variation of cell number in the range of 10(5) to 10(7) cells ml-1 had no significant effects [14].
• Cloning of bacterial genes specifying degradation of 4-chlorobiphenyl from Pseudomonas putida OU83 [15].
• Transfer of the biphenyl- and 4-chlorobiphenyl-degrading phenotype by means of pSS50 was observed at a frequency of 10(-5) per transferred plasmid in matings of A5 with other A. eutrophus strains [2].

Anatomical context of p-Chlorodiphenyl

• 4-Chloro-4'-biphenylol (4'-OH-4-CB), a metabolite of 4-chlorobiphenyl (4-CB), stimulated state 4 respiration and released oligomycin-inhibited state 3 respiration of rat liver mitochondria with succinate as the respiratory substrate [16].
• Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model [17].
• At 24 h a greater presence of 4-chlorobiphenyl and 3,3',4.4'-tetrachlorobiphenyl in the plasma, compared with the erythrocytes, was observed [18].
• Theca interna and granulosa cells from small, medium and large preovulatory porcine follicles were cultured as a monolayer to compare the effects of 4-chlorobiphenyl (PCB3) and its metabolites on estradiol secretion [19].
• 1. Analysis of individual PCB-isomers and congeners in extracts of adipose tissue from N = 12 razorbills suggested that 4-chlorobiphenyl was subjected to metabolism [20].

Associations of p-Chlorodiphenyl with other chemical compounds

• Noninduced rat liver microsomes mediated the covalent binding between the 4-chlorobiphenyl and 4'-chloro-4-biphenylol substrates and endogenous microsomal protein [7].
• Whereas the rate of the first oxidation step at 4-chlorobiphenyl seems to be diminished by the decreased bioavailability of the compound, no considerable differences were observed between the degradation of 4-chloro-4'-hydroxybiphenyl and 4-hydroxybiphenyl [21].
• The IC50 values of p-chlorobiphenyl on the arachidonic acid and collagen-induced platelet aggregation were 2.9 +/- 0.5 and 12.8 +/- 2.3 microM, respectively [22].
• The pcbE gene was composed of 783 base pairs encoding 2-hydroxypenta-2,4-dienoate hydratase involved in the 4-chlorobiphenyl catabolism [23].
• To determine decontamination behavior as affected by temperature, shallow beds of a clay-rich, a calcerous, and a sedimentary soil, artificially polluted with hexachlorobenzene, 4-chlorobiphenyl, naphthalene, or n-decane, were separately heated at 5 degrees C min-1 in a thermogravimetric analyzer [24].

Gene context of p-Chlorodiphenyl

• When administered to immature male Wistar rats, HBBp caused a dose-dependent increase in (a) the activity of benzo[a]pyrene (B[a]P) hydroxylase (AHH) and 4-chlorobiphenyl (4-CBP) hydroxylase and (b) the concentration of cytochrome P-450 [25].
• In the present study, we investigated the metabolic activation of one of those compounds, 4-chlorobiphenyl (PCB 3) [17].
• In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: Effects on sex hormone levels and aromatase activity [26].

References