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Spheroids, Cellular

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Analytical, diagnostic and therapeutic context of Spheroids, Cellular


  1. Development of a 9L rat brain tumor cell multicellular spheroid system and its response to 1,3-bis(2-chloroethyl)-1-nitrosourea and radiation. Deen, D.F., Hoshino, T., Williams, M.E., Muraoka, I., Knebel, K.D., Barker, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  2. Noninvasive detection of elevated glutathione levels in MCF-7 cells resistant to 4-hydroperoxycyclophosphamide. Gamcsik, M.P., Millis, K.K., Colvin, O.M. Cancer Res. (1995) [Pubmed]
  3. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Comerford, K.M., Wallace, T.J., Karhausen, J., Louis, N.A., Montalto, M.C., Colgan, S.P. Cancer Res. (2002) [Pubmed]
  4. In vitro modulation of haematoporphyrin derivative photodynamic therapy on colorectal carcinoma multicellular spheroids by verapamil. Purkiss, S.F., Grahn, M.F., Turkish, M., Macey, M.G., Williams, N.S. The British journal of surgery. (1992) [Pubmed]
  5. Quantification of viability in organotypic multicellular spheroids of human malignant glioma using lactate dehydrogenase activity: a rapid and reliable automated assay. De Witt Hamer, P.C., Jonker, A., Leenstra, S., Ruijter, J.M., Van Noorden, C.J. J. Histochem. Cytochem. (2005) [Pubmed]
  6. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. St Croix, B., Flørenes, V.A., Rak, J.W., Flanagan, M., Bhattacharya, N., Slingerland, J.M., Kerbel, R.S. Nat. Med. (1996) [Pubmed]
  7. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). St Croix, B., Sheehan, C., Rak, J.W., Flørenes, V.A., Slingerland, J.M., Kerbel, R.S. J. Cell Biol. (1998) [Pubmed]
  8. Polyamines are necessary for the survival of human small-cell lung carcinoma in culture. Luk, G.D., Goodwin, G., Marton, L.J., Baylin, S.B. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  9. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Burns, J.S., Abdallah, B.M., Guldberg, P., Rygaard, J., Schrøder, H.D., Kassem, M. Cancer Res. (2005) [Pubmed]
  10. Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. LaRue, K.E., Khalil, M., Freyer, J.P. Cancer Res. (2004) [Pubmed]
  11. Effects of alpha-difluoromethylornithine on the growth of 9L rat brain tumor multicellular spheroids and their response to 1,3-bis(2-chloroethyl)-1-nitrosourea. Sano, Y., Deen, D.F., Oredsson, S.M., Marton, L.J. Cancer Res. (1984) [Pubmed]
  12. The effects of dexamethasone on C6 astrocytoma radiosensitivity. Lordo, C.D., Stroude, E.C., Del Maestro, R.F. J. Neurosurg. (1989) [Pubmed]
  13. The relative effectiveness of analogues of cisplatin in the experimental chemotherapy of human non-small-cell lung cancer and neuroblastoma grown as multicellular spheroids. Russell, J., Adam, J., Wheldon, T.E., Kaye, S.B. Cancer Chemother. Pharmacol. (1989) [Pubmed]
  14. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. Orlandi, P., Barbara, C., Bocci, G., Fioravanti, A., Di Paolo, A., Del Tacca, M., Danesi, R. Journal of chemotherapy (Florence, Italy) (2005) [Pubmed]
  15. Leukotriene and 5-lipoxygenase inhibitor induced variations in thymidine uptake in a human glioma cell line cultured as monolayers or as multicellular spheroids. Gáti, I., Bergström, M., Muhr, C., Carlsson, J. Anticancer Res. (1994) [Pubmed]
  16. Interaction of radiation and AT 1727 in HeLa S-3 cells in culture. He, S.Q., Kim, S.H., Kim, J.H. Int. J. Radiat. Oncol. Biol. Phys. (1985) [Pubmed]
  17. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Mueller-Klieser, W., Freyer, J.P., Sutherland, R.M. Br. J. Cancer (1986) [Pubmed]
  18. Cell-density dependency in the survival kinetics of neocarzinostatin-treated HeLa cells in monolayer cultures and in spheroids. Sasaki, T., Kuroda, Y., Hoshino, F. J. Radiat. Res. (1991) [Pubmed]
  19. Mitochondrial function in oncogene-transfected rat fibroblasts isolated from multicellular spheroids. Kunz-Schughart, L.A., Habbersett, R.C., Freyer, J.P. Am. J. Physiol. (1997) [Pubmed]
  20. Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids. Ponce de León, V., Barrera-Rodríguez, R. Cancer Cell Int. (2005) [Pubmed]
  21. Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma. Waleh, N.S., Gallo, J., Grant, T.D., Murphy, B.J., Kramer, R.H., Sutherland, R.M. Cancer Res. (1994) [Pubmed]
  22. Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids. Sakata, K., Kwok, T.T., Gordon, G.R., Waleh, N.S., Sutherland, R.M. Int. J. Cancer (1994) [Pubmed]
  23. Importance of cell aggregation for expression of liver functions and regeneration demonstrated with primary cultured hepatocytes. Yuasa, C., Tomita, Y., Shono, M., Ishimura, K., Ichihara, A. J. Cell. Physiol. (1993) [Pubmed]
  24. A heterologous in vitro coculture system to study interaction between human bladder cancer cells and fibroblasts. Schuster, U., Büttner, R., Hofstädter, F., Knüchel, R. J. Urol. (1994) [Pubmed]
  25. The role of heat shock protein 70 in the thermoresistance of prostate cancer cell line spheroids. Khoei, S., Goliaei, B., Neshasteh-Riz, A., Deizadji, A. FEBS Lett. (2004) [Pubmed]
  26. Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply. Freyer, J.P., Sutherland, R.M. Cancer Res. (1986) [Pubmed]
  27. Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids. Nederman, T. Cancer Res. (1984) [Pubmed]
  28. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Serganova, I., Doubrovin, M., Vider, J., Ponomarev, V., Soghomonyan, S., Beresten, T., Ageyeva, L., Serganov, A., Cai, S., Balatoni, J., Blasberg, R., Gelovani, J. Cancer Res. (2004) [Pubmed]
  29. Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. Lelièvre, S., Larsen, A.K. Cancer Res. (1994) [Pubmed]
  30. Activity of 4'-(9-acridinylamino)methanesulfon-m-anisidide against Chinese hamster cells in multicellular spheroids. Wilson, W.R., Whitmore, G.F., Hill, R.P. Cancer Res. (1981) [Pubmed]
  31. Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids. Sutherland, R., Buchegger, F., Schreyer, M., Vacca, A., Mach, J.P. Cancer Res. (1987) [Pubmed]
  32. Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture. Görlach, A., Fandrey, J., Holtermann, G., Acker, H. FEBS Lett. (1994) [Pubmed]
  33. Differential expression of adhesion molecules (CD44, ICAM-1 and LFA-3) in cancer cells grown in monolayer or as multicellular spheroids. Rainaldi, G., Calcabrini, A., Arancia, G., Santini, M.T. Anticancer Res. (1999) [Pubmed]
  34. Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages. Hausmann, M., Bataille, F., Spoettl, T., Schreiter, K., Falk, W., Schoelmerich, J., Herfarth, H., Rogler, G. J. Immunol. (2005) [Pubmed]
  35. Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease. Schreiter, K., Hausmann, M., Spoettl, T., Strauch, U.G., Bataille, F., Schoelmerich, J., Herfarth, H., Falk, W., Rogler, G. Gut (2005) [Pubmed]
  36. Effect of cytochalasin B, nocodazole and irradiation on migration and internalization of cells and microspheres in tumor cell spheroids. Dorie, M.J., Kallman, R.F., Coyne, M.A. Exp. Cell Res. (1986) [Pubmed]
  37. Stimulation of glioma-cell migration by laminin and inhibition by anti-alpha3 and anti-beta1 integrin antibodies. Tysnes, B.B., Larsen, L.F., Ness, G.O., Mahesparan, R., Edvardsen, K., Garcia-Cabrera, I., Bjerkvig, R. Int. J. Cancer (1996) [Pubmed]
  38. A three-dimensional cell culture model for bovine endometrium: regeneration of a multicellular spheroid using ascorbate. Yamauchi, N., Yamada, O., Takahashi, T., Imai, K., Sato, T., Ito, A., Hashizume, K. Placenta (2003) [Pubmed]
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