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Chemical Compound Review

Naturine     8-benzyl-10,10-dioxo-4- (trifluoromethyl)...

Synonyms: Aprinox, Berkozide, Livesan, Naturetin, Centyl, ...
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Disease relevance of Bendrofluazide


Psychiatry related information on Bendrofluazide


High impact information on Bendrofluazide


Chemical compound and disease context of Bendrofluazide


Biological context of Bendrofluazide


Anatomical context of Bendrofluazide


Associations of Bendrofluazide with other chemical compounds


Gene context of Bendrofluazide

  • Effect of bendrofluazide on calcium reabsorption in hypoparathyroidism [28].
  • The MRC trial compared bendrofluazide with propranolol and showed a reduction in the incidence of stroke; however, to prevent 1 stroke, 850 patients would have to be treated for 1 year [29].
  • 3. When acutely challenged with bendrofluazide the patients showed a greater increase in plasma renin activity on the second occasion than on the first [30].
  • RESULTS: Urinary calcium decreased dose-dependently in response to the bendroflumethiazide [31].
  • RESULTS: Bendroflumethiazide increased the tubular reabsorption of calcium (TRCa) (+0.46 +/- 0.11%, P=0.009), plasma levels of parathyroid hormones (PTH) (+24 +/- 10%, P=0.06), and 1,25(OH)2D (+12 +/- 6%, P=0.03) [32].

Analytical, diagnostic and therapeutic context of Bendrofluazide


  1. Low renin hypertension. A distinct entity. Thurston, H., Swales, J.D. Lancet (1976) [Pubmed]
  2. Amelioration of bendrofluazide-induced hypokalemia by timolol. Hettiarachchi, J., Ramsay, L.E., Davies, D.L., Fraser, R., Watson, W.S. Clin. Pharmacol. Ther. (1977) [Pubmed]
  3. Aging and susceptibility to drug-induced orthostatic hypotension. Tonkin, A., Wing, L. Clin. Pharmacol. Ther. (1992) [Pubmed]
  4. Role of sodium depletion in acute antidiuretic effect of bendroflumethiazide in rats with nephrogenic diabetes insipidus. Janjua, N.R., Jonassen, T.E., Langhoff, S., Thomsen, K., Christensen, S. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  5. Influence of renal nerves and sodium balance on the acute antidiuretic effect of bendroflumethiazide in rats with diabetes insipidus. Spannow, J., Thomsen, K., Petersen, J.S., Haugan, K., Christensen, S. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  6. A randomized comparison of a conventional dose, a low dose and alternate-day dosing of bendrofluazide in hypertensive patients. Girvin, B., Johnston, G.D. J. Hypertens. (1998) [Pubmed]
  7. The effects of antihypertensive treatment on cognitive function: results from the HOPE study. Starr, J.M., Whalley, L.J., Deary, I.J. Journal of the American Geriatrics Society. (1996) [Pubmed]
  8. Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension. Marshall, A.J., Barritt, D.W., Pocock, J., Heaton, S.T. Lancet (1977) [Pubmed]
  9. Adrenocortical steroids increase renal thiazide diuretic receptor density and response. Chen, Z., Vaughn, D.A., Blakely, P., Fanestil, D.D. J. Am. Soc. Nephrol. (1994) [Pubmed]
  10. Influence of gender on renal thiazide diuretic receptor density and response. Chen, Z., Vaughn, D.A., Fanestil, D.D. J. Am. Soc. Nephrol. (1994) [Pubmed]
  11. Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. Pickkers, P., Garcha, R.S., Schachter, M., Smits, P., Hughes, A.D. Hypertension (1999) [Pubmed]
  12. Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations. Winchester, J.F., Kellett, R.J., Boddy, K., Boyle, P., Dargie, H.J., Mahaffey, M.E., Ward, D.M., Kennedy, A.C. Clin. Pharmacol. Ther. (1980) [Pubmed]
  13. Comparison of the effects of a 7-day period of non-compliance on blood pressure control using three different antihypertensive agents. Girvin, B.G., Johnston, G.D. J. Hypertens. (2004) [Pubmed]
  14. Enalapril versus bendroflumethiazide in type 2 diabetes complicated by hypertension. Nielsen, S., Schmitz, A., Knudsen, R.E., Dollerup, J., Mogensen, C.E. QJM : monthly journal of the Association of Physicians. (1994) [Pubmed]
  15. Indapamide and bendrofluazide: a comparison in the management of essential hypertension. Bing, R.F., Russell, G.I., Swales, J.D., Thurston, H. British journal of clinical pharmacology. (1981) [Pubmed]
  16. The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide. Sigurd, B., Olesen, K.H., Wennevold, A. Am. Heart J. (1975) [Pubmed]
  17. Pharmacokinetics of bendroflumethiazide. Beermann, B., Groschinsky-Grind, M., Lindström, B. Clin. Pharmacol. Ther. (1977) [Pubmed]
  18. Comparison of the hypotensive and metabolic effects of bendrofluazide therapy and a high fibre, low fat, low sodium diet in diabetic subjects with mild hypertension. Pacy, P.J., Dodson, P.M., Kubicki, A.J., Fletcher, R.F., Taylor, K.G. J. Hypertens. (1984) [Pubmed]
  19. The systemic haemodynamic and cerebral autoregulatory effects of bendrofluazide in the subacute post-stroke period. Eames, P.J., Robinson, T.G., Panerai, R.B., Potter, J.F. J. Hypertens. (2004) [Pubmed]
  20. Effects of long term treatment with pinacidil and nifedipine on left ventricular anatomy and function in patients with mild to moderate systemic hypertension. Steensgaard-Hansen, F., Carlsen, J.E. Drugs (1988) [Pubmed]
  21. The blood pressure response to antihypertensive treatment with lisinopril or bendrofluazide is related to the calcium and magnesium contents in skeletal muscle. Haenni, A., Lind, L., Lithell, H. Am. J. Hypertens. (1996) [Pubmed]
  22. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Lysaa, R.A., Giverhaug, T., Wold, H.L., Aarbakke, J. Eur. J. Clin. Pharmacol. (1996) [Pubmed]
  23. Effect of bendroflumethiazide on Na+ and Ca++ transport in rat and guinea pig jejunum. Jorgensen, F.S., Rask-Madsen, J. Acta pharmacologica et toxicologica. (1976) [Pubmed]
  24. Effects of diuretic and beta-blocker therapy in the Medical Research Council Trial. Greenberg, G., Brennan, P.J., Miall, W.E. Am. J. Med. (1984) [Pubmed]
  25. A double-blind study of the blood pressure lowering effect of a thiazide diuretic in hypertensive patients already on nifedipine and a beta-blocker. Cappuccio, F.P., Markandu, N.D., Tucker, F.A., Shore, A.C., MacGregor, G.A. J. Hypertens. (1987) [Pubmed]
  26. Effects of combination therapy with an angiotensin converting enzyme inhibitor and thiazide diuretic on insulin action in essential hypertension. Hunter, S.J., Harper, R., Ennis, C.N., Crothers, E., Sheridan, B., Johnston, G.D., Atkinson, A.B., Bell, P.M. J. Hypertens. (1998) [Pubmed]
  27. Comparison of enalapril and bendrofluazide for treatment of systemic hypertension. Zezulka, A.V., Gill, J.S., Dews, I., Joy, M.D., Beevers, D.G. Am. J. Cardiol. (1987) [Pubmed]
  28. Effect of bendrofluazide on calcium reabsorption in hypoparathyroidism. Newman, G.H., Wade, M., Hosking, D.J. Eur. J. Clin. Pharmacol. (1984) [Pubmed]
  29. Future approaches to the treatment of hypertension in the light of results from recent trials. Ball, S.G. Drugs (1988) [Pubmed]
  30. Plasma renin in long-term diuretic treatment of hypertension: effect of discontinuation and restarting therapy. Swart, S., Bing, R.F., Swales, J.D., Thurston, H. Clin. Sci. (1982) [Pubmed]
  31. Dose-effect relations of loop- and thiazide-diuretics on calcium homeostasis: a randomized, double-blinded Latin-square multiple cross-over study in postmenopausal osteopenic women. Rejnmark, L., Vestergaard, P., Pedersen, A.R., Heickendorff, L., Andreasen, F., Mosekilde, L. Eur. J. Clin. Invest. (2003) [Pubmed]
  32. Effects of thiazide- and loop-diuretics, alone or in combination, on calcitropic hormones and biochemical bone markers: a randomized controlled study. Rejnmark, L., Vestergaard, P., Heickendorff, L., Andreasen, F., Mosekilde, L. J. Intern. Med. (2001) [Pubmed]
  33. Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol. Lipworth, B.J., McDevitt, D.G., Struthers, A.D. Am. J. Med. (1989) [Pubmed]
  34. Electrolyte changes and metabolic effects of lisinopril/bendrofluazide treatment. Results from a randomized, double-blind study with parallel groups. Haenni, A., Andersson, P.E., Lind, L., Berne, C., Lithell, H. Am. J. Hypertens. (1994) [Pubmed]
  35. High-performance liquid chromatographic analysis of nadolol and bendroflumethiazide combination tablet formulations. Perlman, S., Szyper, M., Kirschbaum, J.J. Journal of pharmaceutical sciences. (1984) [Pubmed]
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