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Chemical Compound Review

Prestwick_606     4-chloro-N-(2-methyl-2,3- dihydro-1H-indol...

Synonyms: SureCN3626029, AC1O4WHH, KB-52638
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Disease relevance of indapamide


High impact information on indapamide


Chemical compound and disease context of indapamide


Biological context of indapamide


Anatomical context of indapamide


Associations of indapamide with other chemical compounds


Gene context of indapamide


Analytical, diagnostic and therapeutic context of indapamide

  • Tolerability and well-being with indapamide in the treatment of mild-moderate hypertension. An Italian multicenter study [28].
  • The effect of long-term treatment with indapamide in platelet alpha 2-adrenoceptors has been evaluated in 10 patients with essential hypertension, in a double-blind, cross-over study with placebo [8].
  • Fifteen patients with mild-to-moderate hypertension (10 with normal and five with decreased renal function) were studied after treatment with placebo and low (1 mg), intermediate (2.5 mg), and high (5.0 mg per day) doses of indapamide, each for four weeks [20].
  • Intravenous injections of 0.5 ml/kg of 1 x 10(-5), 1 x 10(-4), and 1 x 10(-3) M indapamide solutions reduced mean arterial pressure from 123 to 114, 130 to 113, and 128 to 114 mm Hg and the plasma phosphate concentrations from 6.4 to 4.2, 6.6 to 4.8, and 7.0 to 4.5 mg/dl, respectively [19].
  • In addition to studies of the efficacy and tolerance of indapamide, the study comprised an assessment of well-being, which was carried out objectively by the physician, and subjectively by the patient himself, by means of a list of complaints and a visual analogue scale [3].


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  2. Endothelial dysfunction and cardiorenal injury in experimental salt-sensitive hypertension: effects of antihypertensive therapy. Hayakawa, H., Coffee, K., Raij, L. Circulation (1997) [Pubmed]
  3. Assessment of indapamide in elderly hypertensive patients with special emphasis on well-being. Werning, C., Weitz, T., Ludwig, B. Am. J. Med. (1988) [Pubmed]
  4. Hypertension in elderly patients. A comparative study between indapamide and hydrochlorothiazide. Plante, G.E., Dessurault, D.L. Am. J. Med. (1988) [Pubmed]
  5. Efficacy of indapamide in central diabetes insipidus. Tetiker, T., Sert, M., Koçak, M. Arch. Intern. Med. (1999) [Pubmed]
  6. Effects of the diuretic agent indapamide on Na+, transient outward, and delayed rectifier currents in canine atrial myocytes. Lu, Y., Yue, L., Wang, Z., Nattel, S. Circ. Res. (1998) [Pubmed]
  7. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. Lalande, A., Roux, S., Denne, M.A., Stanley, E.R., Schiavi, P., Guez, D., De Vernejoul, M.C. J. Bone Miner. Res. (2001) [Pubmed]
  8. Platelet alpha 2-adrenoceptor modifications induced by long-term treatment with indapamide in essential hypertension. Carretta, R., Fabris, B., Fischetti, F., Muiesan, S., Bardelli, M., Melchior, C., Cesanelli, R., Pizzolitto, A., Giraldi, T., Greco, P.L. Am. J. Med. (1988) [Pubmed]
  9. Analysis of well-being and 24-hour blood pressure recording in a comparative study between indapamide and captopril. Lacourciere, Y. Am. J. Med. (1988) [Pubmed]
  10. The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension. Hayakawa, H., Raij, L. Hypertension (1997) [Pubmed]
  11. Fixed-dose combination of perindopril with indapamide in spontaneously hypertensive rats: haemodynamic, biological and structural effects. Richard, V., Joannides, R., Henry, J.P., Mulder, P., Mace, B., Guez, D., Schiavi, P., Thuillez, C. J. Hypertens. (1996) [Pubmed]
  12. Clinical positioning of indapamide sustained release 1.5mg in management protocols for hypertension. Leonetti, G. Drugs (2000) [Pubmed]
  13. Severe lithium toxicity associated with indapamide therapy. Hanna, M.E., Lobao, C.B., Stewart, J.T. Journal of clinical psychopharmacology. (1990) [Pubmed]
  14. Indapamide-induced inhibition of calcium movement in smooth muscles. Mironneau, J. Am. J. Med. (1988) [Pubmed]
  15. A review of 10 years of experience with indapamide as an antihypertensive agent. Thomas, J.R. Hypertension (1985) [Pubmed]
  16. Thiazide-induced vasodilation in humans is mediated by potassium channel activation. Pickkers, P., Hughes, A.D., Russel, F.G., Thien, T., Smits, P. Hypertension (1998) [Pubmed]
  17. Galenic development and pharmacokinetic profile of indapamide sustained release 1.5 mg. Damien, G., Huet de Barochez, B., Schiavi, P. Clinical pharmacokinetics. (1999) [Pubmed]
  18. Sodium and large arteries in hypertension. Effects of indapamide. Safar, M., Laurent, S., Safavian, A., Pannier, B., Asmar, R. Am. J. Med. (1988) [Pubmed]
  19. Effect of indapamide on phosphate metabolism and vascular reactivity. Plante, G.E., Lafreniere, M.C., Tam, P.T., Sirois, P. Am. J. Med. (1988) [Pubmed]
  20. Cardiovascular effects of indapamide in hypertensive patients with or without renal failure. A dose-response curve. Leenen, F.H., Smith, D.L., Farkas, R.M., Boer, W.H., Reeves, R.A., Marquez-Julio, A. Am. J. Med. (1988) [Pubmed]
  21. Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats. Contard, F., Sabri, A., Glukhova, M., Sartore, S., Marotte, F., Pomies, J.P., Schiavi, P., Guez, D., Samuel, J.L., Rappaport, L. Hypertension (1993) [Pubmed]
  22. Indapamide in the treatment of hypertension in non-insulin-dependent diabetes. Raggi, U., Palumbo, P., Moro, B., Bevilacqua, M., Norbiato, G. Hypertension (1985) [Pubmed]
  23. Serum lipoprotein levels during long-term treatment of hypertension with indapamide. Meyer-Sabellek, W., Gotzen, R., Heitz, J., Arntz, H.R., Schulte, K.L. Hypertension (1985) [Pubmed]
  24. Demonstration of an in vitro direct vascular relaxant effect of diuretics in the presence of plasma. Abrahams, Z., Tan, L.L., Pang, M.Y., Abrahams, B., Tan, M.M., Wright, J.M. J. Hypertens. (1996) [Pubmed]
  25. The inhibitory effect of diuretics on carbonic anhydrases. Puscas, I., Coltau, M., Baican, M., Pasca, R., Domuta, G. Res. Commun. Mol. Pathol. Pharmacol. (1999) [Pubmed]
  26. Growth inhibitory activity of indapamide on vascular smooth muscle cells. Ganado, P., Ruiz, E., Del Rio, M., Larcher, F., Sanz, M., Steinert, J.R., Tejerina, T. Eur. J. Pharmacol. (2001) [Pubmed]
  27. Alteration of renal receptors for atrial natriuretic peptide and vasopressin in spontaneously hypertensive rats treated with antihypertensive diuretics. Ogura, T., Nishida, N., Watanabe, H., Omiya, T., Yamauchi, T., Hosoya, M., Hirata, H., Kashihara, N., Ota, Z. Res. Commun. Chem. Pathol. Pharmacol. (1994) [Pubmed]
  28. Tolerability and well-being with indapamide in the treatment of mild-moderate hypertension. An Italian multicenter study. Leonetti, G., Rappelli, A., Salvetti, A., Scapellato, L. Am. J. Med. (1988) [Pubmed]
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