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Chemical Compound Review

Calmday     10-chloro-2-phenyl-3,6...

Synonyms: Vegesan, Nordaz, Nordazepam, Nordiazepam, Norprazepam, ...
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Disease relevance of Nordazepam


Psychiatry related information on Nordazepam


High impact information on Nordazepam


Chemical compound and disease context of Nordazepam


Biological context of Nordazepam


Anatomical context of Nordazepam


Associations of Nordazepam with other chemical compounds


Gene context of Nordazepam

  • 5. Our results suggest that in the human liver, the metabolism of diazepam to nordiazepam is mediated by CYP3A4, which has been reported as the most abundant P450 form in human liver as well as 2C19, which has been reported as a polymorphic enzyme [32].
  • The formations of their metabolites, 4'-hydroxymephenytoin (4'-OH-MP), demethyldiazepam, and 5-hydroxyomeprazole (5-OH-OP) are CYP2C19 genotype dependent [33].
  • Although endozepine peaks 1 and 2 had HPLC retention profiles similar to those of nordiazepam and diazepam, respectively, gas chromatography-mass spectrometry as well as high-performance TLC revealed biologically insignificant amounts of diazepam (less than 0.02 pg/g) and nordiazepam (less than 0.02 pg/g) in the purified material [34].
  • Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF [35].
  • The MAbs to 1A1, 1A2, 2A6, 2D6, and 2E1 did not inhibit TMZ or nordiazepam formation; this indicates their noninvolvement in DZ metabolism [36].

Analytical, diagnostic and therapeutic context of Nordazepam


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  13. Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam. Reilly, P.E., Thompson, D.A., Mason, S.R., Hooper, W.D. Mol. Pharmacol. (1990) [Pubmed]
  14. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects. Zhang, Y.A., Reviriego, J., Lou, Y.Q., Sjöqvist, F., Bertilsson, L. Clin. Pharmacol. Ther. (1990) [Pubmed]
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  16. Effects of propranolol, atenolol, and chlordesmethyldiazepam on response to mental stress in patients with recent myocardial infarction. Mazzuero, G., Galdangelo, F., Zotti, A.M., Bertolotti, G., Tavazzi, L. Clinical cardiology. (1987) [Pubmed]
  17. More reliable brain death diagnosis with chromatographic analysis of midazolam, diazepam, thiopentone, and active metabolites. Meinitzer, A., März, W., Mangge, H., Halwachs-Baumann, G. Journal of analytical toxicology. (2006) [Pubmed]
  18. Effects on learning and memory of 2-week treatments with chlordiazepoxide lactam, N-desmethyldiazepam, oxazepam and methyloxazepam, alone or in combination with alcohol. Liljequist, R., Palva, E., Linnoila, M. International pharmacopsychiatry. (1979) [Pubmed]
  19. Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. Klotz, U., Antonin, K.H., Brügel, H., Bieck, P.R. Clin. Pharmacol. Ther. (1977) [Pubmed]
  20. Intravenous diazepam and oral ethanol interaction. Sellers, E.M., Naranjo, C.A., Giles, H.G., Frecker, R.C., Beeching, M. Clin. Pharmacol. Ther. (1980) [Pubmed]
  21. Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector. Dhar, A.K., Kutt, H. Clin. Chem. (1979) [Pubmed]
  22. Kinetics and neuropsychologic effects of IV diazepam in the presence and absence of its active N-desmethyl metabolite in humans. Elsass, P., Hendel, J., Hvidberg, E.F., Hansen, T., Gymoese, E., Rathje, J. Psychopharmacology (Berl.) (1980) [Pubmed]
  23. Entry of diazepam and its major matabolite into cerebrospinal fluid. Greenblatt, D.J., Ochs, H.R., Lloyd, B.L. Psychopharmacology (Berl.) (1980) [Pubmed]
  24. Placental transfer to diazepam and its disposition in the newborn. Mandelli, M., Morselli, P.L., Nordio, S., Pardi, G., Principi, N., Sereni, F., Tognoni, G. Clin. Pharmacol. Ther. (1975) [Pubmed]
  25. Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. Yasumori, T., Li, Q.H., Yamazoe, Y., Ueda, M., Tsuzuki, T., Kato, R. Pharmacogenetics (1994) [Pubmed]
  26. Psychomotor effects of diazepam in anxious patients and healthy volunteers. Linnoila, M., Erwin, C.W., Brendle, A., Simpson, D. Journal of clinical psychopharmacology. (1983) [Pubmed]
  27. Metabolism of prazepam by rat liver microsomes: stereoselective formation and N-dealkylation of 3-hydroxyprazepam. Lu, X.L., Yang, S.K. Mol. Pharmacol. (1989) [Pubmed]
  28. Propranolol interactions with diazepam, lorazepam, and alprazolam. Ochs, H.R., Greenblatt, D.J., Verburg-Ochs, B. Clin. Pharmacol. Ther. (1984) [Pubmed]
  29. N-desmethyldiazepam: a new metabolite of chlordiazepoxide in man. Dixon, R., Brooks, M.A., Postma, E., Hackman, M.R., Spector, S., Moore, J.D., Schwartz, M.A. Clin. Pharmacol. Ther. (1976) [Pubmed]
  30. Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers. Gardner, M.J., Baris, B.A., Wilner, K.D., Preskorn, S.H. Clinical pharmacokinetics. (1997) [Pubmed]
  31. Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography. Greenblatt, D.J., Locniskar, A., Shader, R.I. Psychopharmacology (Berl.) (1983) [Pubmed]
  32. Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Ono, S., Hatanaka, T., Miyazawa, S., Tsutsui, M., Aoyama, T., Gonzalez, F.J., Satoh, T. Xenobiotica (1996) [Pubmed]
  33. CYP2C19 genotype determines enzyme activity and inducibility of S-mephenytoin hydroxylase. Zhou, H.H. Clin. Chim. Acta (2001) [Pubmed]
  34. Purification and characterization of naturally occurring benzodiazepine receptor ligands in rat and human brain. Rothstein, J.D., Garland, W., Puia, G., Guidotti, A., Weber, R.J., Costa, E. J. Neurochem. (1992) [Pubmed]
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  36. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Yang, T.J., Krausz, K.W., Sai, Y., Gonzalez, F.J., Gelboin, H.V. Drug Metab. Dispos. (1999) [Pubmed]
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  40. Effect of antacids on absorption of clorazepate. Chun, A.H., Carrigan, P.J., Hoffman, D.J., Kershner, R.P., Stuart, J.D. Clin. Pharmacol. Ther. (1977) [Pubmed]
  41. Evaluation of an enzyme immunoassay for determining diazepam and nordiazepam in serum and urine. Wallace, J.E., Harris, S.C., Shimek, E.L. Clin. Chem. (1980) [Pubmed]
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