The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Calmday     10-chloro-2-phenyl-3,6...

Synonyms: Vegesan, Nordaz, Nordazepam, Nordiazepam, Norprazepam, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nordazepam

 

Psychiatry related information on Nordazepam

 

High impact information on Nordazepam

 

Chemical compound and disease context of Nordazepam

 

Biological context of Nordazepam

 

Anatomical context of Nordazepam

 

Associations of Nordazepam with other chemical compounds

 

Gene context of Nordazepam

  • 5. Our results suggest that in the human liver, the metabolism of diazepam to nordiazepam is mediated by CYP3A4, which has been reported as the most abundant P450 form in human liver as well as 2C19, which has been reported as a polymorphic enzyme [32].
  • The formations of their metabolites, 4'-hydroxymephenytoin (4'-OH-MP), demethyldiazepam, and 5-hydroxyomeprazole (5-OH-OP) are CYP2C19 genotype dependent [33].
  • Although endozepine peaks 1 and 2 had HPLC retention profiles similar to those of nordiazepam and diazepam, respectively, gas chromatography-mass spectrometry as well as high-performance TLC revealed biologically insignificant amounts of diazepam (less than 0.02 pg/g) and nordiazepam (less than 0.02 pg/g) in the purified material [34].
  • Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF [35].
  • The MAbs to 1A1, 1A2, 2A6, 2D6, and 2E1 did not inhibit TMZ or nordiazepam formation; this indicates their noninvolvement in DZ metabolism [36].
 

Analytical, diagnostic and therapeutic context of Nordazepam

References

  1. Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy. Basile, A.S., Harrison, P.M., Hughes, R.D., Gu, Z.Q., Pannell, L., McKinney, A., Jones, E.A., Williams, R. Hepatology (1994) [Pubmed]
  2. N-desmethyldiazepam physical dependence in dogs. McNicholas, L.F., Martin, W.R., Pruitt, T.A. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  3. Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam. Klockowski, P.M., Levy, G. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  4. Benzodiazepines: a summary of pharmacokinetic properties. Greenblatt, D.J., Shader, R.I., Divoll, M., Harmatz, J.S. British journal of clinical pharmacology. (1981) [Pubmed]
  5. Benzodiazepine withdrawal symptoms and propranolol. Tyrer, P., Rutherford, D., Huggett, T. Lancet (1981) [Pubmed]
  6. Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice. de Angelis, L., File, S.E. Psychopharmacology (Berl.) (1979) [Pubmed]
  7. Effect of N-desmethyldiazepam (nordiazepam) and a precursor, potassium clorazepate, on sleep in man. Nicholson, A.N., Stone, B.M., Clarke, C.H., Ferres, H.M. British journal of clinical pharmacology. (1976) [Pubmed]
  8. The effects of chlordesmethyldiazepam on behavioral performance and subjective judgment in normal subjects. Zimmermann-Tansella, C., Tansella, M., Lader, M. Journal of clinical pharmacology. (1976) [Pubmed]
  9. The use of short- and long-acting hypnotics in clinical medicine. Nicholson, A.N. British journal of clinical pharmacology. (1981) [Pubmed]
  10. Rapid recovery from massive diazepam overdose. Greenblatt, D.J., Woo, E., Allen, M.D., Orsulak, P.J., Shader, R.I. JAMA (1978) [Pubmed]
  11. Interethnic difference in omeprazole's inhibition of diazepam metabolism. Caraco, Y., Tateishi, T., Wood, A.J. Clin. Pharmacol. Ther. (1995) [Pubmed]
  12. Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Sohn, D.R., Kusaka, M., Ishizaki, T., Shin, S.G., Jang, I.J., Shin, J.G., Chiba, K. Clin. Pharmacol. Ther. (1992) [Pubmed]
  13. Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam. Reilly, P.E., Thompson, D.A., Mason, S.R., Hooper, W.D. Mol. Pharmacol. (1990) [Pubmed]
  14. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects. Zhang, Y.A., Reviriego, J., Lou, Y.Q., Sjöqvist, F., Bertilsson, L. Clin. Pharmacol. Ther. (1990) [Pubmed]
  15. Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog. Sloan, J.W., Martin, W.R., Wala, E., Dickey, K.M. Drug and alcohol dependence. (1991) [Pubmed]
  16. Effects of propranolol, atenolol, and chlordesmethyldiazepam on response to mental stress in patients with recent myocardial infarction. Mazzuero, G., Galdangelo, F., Zotti, A.M., Bertolotti, G., Tavazzi, L. Clinical cardiology. (1987) [Pubmed]
  17. More reliable brain death diagnosis with chromatographic analysis of midazolam, diazepam, thiopentone, and active metabolites. Meinitzer, A., März, W., Mangge, H., Halwachs-Baumann, G. Journal of analytical toxicology. (2006) [Pubmed]
  18. Effects on learning and memory of 2-week treatments with chlordiazepoxide lactam, N-desmethyldiazepam, oxazepam and methyloxazepam, alone or in combination with alcohol. Liljequist, R., Palva, E., Linnoila, M. International pharmacopsychiatry. (1979) [Pubmed]
  19. Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. Klotz, U., Antonin, K.H., Brügel, H., Bieck, P.R. Clin. Pharmacol. Ther. (1977) [Pubmed]
  20. Intravenous diazepam and oral ethanol interaction. Sellers, E.M., Naranjo, C.A., Giles, H.G., Frecker, R.C., Beeching, M. Clin. Pharmacol. Ther. (1980) [Pubmed]
  21. Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector. Dhar, A.K., Kutt, H. Clin. Chem. (1979) [Pubmed]
  22. Kinetics and neuropsychologic effects of IV diazepam in the presence and absence of its active N-desmethyl metabolite in humans. Elsass, P., Hendel, J., Hvidberg, E.F., Hansen, T., Gymoese, E., Rathje, J. Psychopharmacology (Berl.) (1980) [Pubmed]
  23. Entry of diazepam and its major matabolite into cerebrospinal fluid. Greenblatt, D.J., Ochs, H.R., Lloyd, B.L. Psychopharmacology (Berl.) (1980) [Pubmed]
  24. Placental transfer to diazepam and its disposition in the newborn. Mandelli, M., Morselli, P.L., Nordio, S., Pardi, G., Principi, N., Sereni, F., Tognoni, G. Clin. Pharmacol. Ther. (1975) [Pubmed]
  25. Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. Yasumori, T., Li, Q.H., Yamazoe, Y., Ueda, M., Tsuzuki, T., Kato, R. Pharmacogenetics (1994) [Pubmed]
  26. Psychomotor effects of diazepam in anxious patients and healthy volunteers. Linnoila, M., Erwin, C.W., Brendle, A., Simpson, D. Journal of clinical psychopharmacology. (1983) [Pubmed]
  27. Metabolism of prazepam by rat liver microsomes: stereoselective formation and N-dealkylation of 3-hydroxyprazepam. Lu, X.L., Yang, S.K. Mol. Pharmacol. (1989) [Pubmed]
  28. Propranolol interactions with diazepam, lorazepam, and alprazolam. Ochs, H.R., Greenblatt, D.J., Verburg-Ochs, B. Clin. Pharmacol. Ther. (1984) [Pubmed]
  29. N-desmethyldiazepam: a new metabolite of chlordiazepoxide in man. Dixon, R., Brooks, M.A., Postma, E., Hackman, M.R., Spector, S., Moore, J.D., Schwartz, M.A. Clin. Pharmacol. Ther. (1976) [Pubmed]
  30. Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers. Gardner, M.J., Baris, B.A., Wilner, K.D., Preskorn, S.H. Clinical pharmacokinetics. (1997) [Pubmed]
  31. Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography. Greenblatt, D.J., Locniskar, A., Shader, R.I. Psychopharmacology (Berl.) (1983) [Pubmed]
  32. Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Ono, S., Hatanaka, T., Miyazawa, S., Tsutsui, M., Aoyama, T., Gonzalez, F.J., Satoh, T. Xenobiotica (1996) [Pubmed]
  33. CYP2C19 genotype determines enzyme activity and inducibility of S-mephenytoin hydroxylase. Zhou, H.H. Clin. Chim. Acta (2001) [Pubmed]
  34. Purification and characterization of naturally occurring benzodiazepine receptor ligands in rat and human brain. Rothstein, J.D., Garland, W., Puia, G., Guidotti, A., Weber, R.J., Costa, E. J. Neurochem. (1992) [Pubmed]
  35. Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF. Hallstrom, C., Lader, M.H. British journal of clinical pharmacology. (1980) [Pubmed]
  36. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Yang, T.J., Krausz, K.W., Sai, Y., Gonzalez, F.J., Gelboin, H.V. Drug Metab. Dispos. (1999) [Pubmed]
  37. A rapid and sensitive radioreceptor assay for benzodiazepine in plasma. Skolnick, P., Goodwin, F.K., Paul, S.M. Arch. Gen. Psychiatry (1979) [Pubmed]
  38. Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy. Basile, A.S., Pannell, L., Jaouni, T., Gammal, S.H., Fales, H.M., Jones, E.A., Skolnick, P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  39. Diazepam effects and kinetics in Caucasians and Orientals. Ghoneim, M.M., Korttila, K., Chiang, C.K., Jacobs, L., Schoenwald, R.D., Mewaldt, S.P., Kayaba, K.O. Clin. Pharmacol. Ther. (1981) [Pubmed]
  40. Effect of antacids on absorption of clorazepate. Chun, A.H., Carrigan, P.J., Hoffman, D.J., Kershner, R.P., Stuart, J.D. Clin. Pharmacol. Ther. (1977) [Pubmed]
  41. Evaluation of an enzyme immunoassay for determining diazepam and nordiazepam in serum and urine. Wallace, J.E., Harris, S.C., Shimek, E.L. Clin. Chem. (1980) [Pubmed]
 
WikiGenes - Universities