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Chemical Compound Review

AC1MHEOC     pyrrolidin-1- ylsulfanylmethanethioamide

Synonyms: Pyrrolidine-Dithiocarbamate, pyrrolidin-1-yl carbamodithioate, Dithiocarbamic acid pyrrolidin-1-yl ester
 
 
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Disease relevance of Pyrrolidine-Dithiocarbamate

  • Desferal (100 microM), a chelator of iron and other metal ions, had no significant effect on bone resorption, indicating (along with the results with NAC) that ROI-scavenging rather than metal chelation is responsible for inhibition of osteoclastic bone resorption by PDTC [1].
 

High impact information on Pyrrolidine-Dithiocarbamate

 

Biological context of Pyrrolidine-Dithiocarbamate

 

Anatomical context of Pyrrolidine-Dithiocarbamate

 

Associations of Pyrrolidine-Dithiocarbamate with other chemical compounds

 

Gene context of Pyrrolidine-Dithiocarbamate

  • This study also addresses PDTC and Sper-NO effects on activation of nuclear factor kappa B (NF-kappaB) induced by TNF-alpha (10 ng/ml) [7].
  • PDTC also decreased the effects of EA on TNF-alpha production significantly [18].
  • PDTC independently decreased both SP-A and SP-B mRNAs [19].
  • PDTC, on the other hand, did not affect the induction of the uPA gene by TNF alpha [16].
  • These findings indicate that TNF-alpha induces NF-kappaB activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC [20].
 

Analytical, diagnostic and therapeutic context of Pyrrolidine-Dithiocarbamate

  • PDTC (0.01 mM) caused no change in the ratio of resorption pit area to resorption pit depth as measured by Lasertec confocal microscopy, indicating that ROI are not involved in the resorptive process per se [1].
  • This paper describes an adhesion/invasion assay, based on combined pyrrolidine dithiocarbamate (PDTC) and antibody treatment of parasites followed by quantitative real-time PCR [21].

References

  1. The role of reactive oxygen intermediates in osteoclastic bone resorption. Hall, T.J., Schaeublin, M., Jeker, H., Fuller, K., Chambers, T.J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  2. Evidence that reactive oxygen species do not mediate NF-kappaB activation. Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., Kikugawa, K. EMBO J. (2003) [Pubmed]
  3. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Koptyra, M., Falinski, R., Nowicki, M.O., Stoklosa, T., Majsterek, I., Nieborowska-Skorska, M., Blasiak, J., Skorski, T. Blood (2006) [Pubmed]
  4. Stimulation of Fc gamma receptors in rat peritoneal macrophages induces the expression of nitric oxide synthase and chemokines by mechanisms showing different sensitivities to antioxidants and nitric oxide donors. Bayón, Y., Alonso, A., Sánchez Crespo, M. J. Immunol. (1997) [Pubmed]
  5. Antioxidants inhibit interleukin-1-induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells. Evidence for post-transcriptional regulation. Tetsuka, T., Baier, L.D., Morrison, A.R. J. Biol. Chem. (1996) [Pubmed]
  6. NF-kappaB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection. Lim, J.W., Kim, H., Kim, K.H. Free Radic. Biol. Med. (2001) [Pubmed]
  7. Effects of antioxidant and nitric oxide on chemokine production in TNF-alpha-stimulated human dermal microvascular endothelial cells. Jiang, M.Z., Tsukahara, H., Ohshima, Y., Sato, S., Todoroki, Y., Hiraoka, M., Mayumi, M. Free Radic. Res. (2004) [Pubmed]
  8. Activation of NF-kappaB is involved in 6-hydroxydopamine-but not MPP+ -induced dopaminergic neuronal cell death: its potential role as a survival determinant. Park, S.H., Choi, W.S., Yoon, S.Y., Ahn, Y.S., Oh, Y.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. Induction of nitric oxide synthase by Oldenlandia diffusa in mouse peritoneal macrophages. Chung, H.S., Jeong, H.J., Hong, S.H., Kim, M.S., Kim, S.J., Song, B.K., Jeong, I.S., Lee, E.J., Ahn, J.W., Baek, S.H., Kim, H.M. Biol. Pharm. Bull. (2002) [Pubmed]
  10. Poorer NF-kappa B signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. Mukhopadhyay, S., Srivastava, V.M., Murthy, P.K., Hasnain, S.E. FEBS Lett. (2004) [Pubmed]
  11. Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells. Jiang, M.Z., Tsukahara, H., Hayakawa, K., Todoroki, Y., Tamura, S., Ohshima, Y., Hiraoka, M., Mayumi, M. Respiratory medicine. (2005) [Pubmed]
  12. Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line. Kone, B.C., Schwöbel, J., Turner, P., Mohaupt, M.G., Cangro, C.B. Am. J. Physiol. (1995) [Pubmed]
  13. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis. Kühn, K., Shikhman, A.R., Lotz, M. J. Cell. Physiol. (2003) [Pubmed]
  14. Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. Kengatharan, M., De Kimpe, S.J., Thiemermann, C. Br. J. Pharmacol. (1996) [Pubmed]
  15. Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium. Ozawa, N., Shichiri, M., Iwashina, M., Fukai, N., Yoshimoto, T., Hirata, Y. Hypertens. Res. (2004) [Pubmed]
  16. Effect of radical scavengers on TNF alpha-mediated activation of the uPA in cultured cells. Egawa, K., Yoshiwara, M., Nose, K. Experientia (1994) [Pubmed]
  17. Induction of nitric oxide synthase by saponins of heat-processed ginseng. Kim, J.Y., Lee, H.J., Kim, J.S., Ryu, J.H. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  18. Activation of inducible nitric oxide synthase by Euonymus alatus in mouse peritoneal macrophages. Chung, H.S., Jeong, H.J., Kim, J.S., Jeong, S.I., Kim, K.S., Kim, K.S., Kang, B.K., Ahn, J.W., Baek, S.H., Kim, H.M. Clin. Chim. Acta (2002) [Pubmed]
  19. Regulation of surfactant proteins A and B by TNF-alpha and phorbol ester independent of NF-kappa B. Pryhuber, G.S., Khalak, R., Zhao, Q. Am. J. Physiol. (1998) [Pubmed]
  20. E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation. Rahman, A., Kefer, J., Bando, M., Niles, W.D., Malik, A.B. Am. J. Physiol. (1998) [Pubmed]
  21. Neospora caninum and Toxoplasma gondii: a novel adhesion/invasion assay reveals distinct differences in tachyzoite-host cell interactions. Naguleswaran, A., Müller, N., Hemphill, A. Exp. Parasitol. (2003) [Pubmed]
 
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