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Chemical Compound Review

L-NMMA     (2S)-2-amino-5-[(N'- methylcarbamimidoyl)am...

Synonyms: ANO-1020, CHEMBL1256175, M7033_SIGMA, CCG-100805, AC1Q5SZL, ...
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Disease relevance of C03884


High impact information on C03884


Chemical compound and disease context of C03884


Biological context of C03884


Anatomical context of C03884


Associations of C03884 with other chemical compounds


Gene context of C03884


Analytical, diagnostic and therapeutic context of C03884


  1. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). Adler, H., Beland, J.L., Del-Pan, N.C., Kobzik, L., Brewer, J.P., Martin, T.R., Rimm, I.J. J. Exp. Med. (1997) [Pubmed]
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  3. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Baron, A.D., Tarshoby, M., Hook, G., Lazaridis, E.N., Cronin, J., Johnson, A., Steinberg, H.O. Diabetes (2000) [Pubmed]
  4. A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1(+) macrophages that suppress naive CD4(+) T cell proliferation via an IFN-gamma and nitric oxide-dependent mechanism. Atochina, O., Daly-Engel, T., Piskorska, D., McGuire, E., Harn, D.A. J. Immunol. (2001) [Pubmed]
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  6. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. Tilton, R.G., Kawamura, T., Chang, K.C., Ido, Y., Bjercke, R.J., Stephan, C.C., Brock, T.A., Williamson, J.R. J. Clin. Invest. (1997) [Pubmed]
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  15. Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia. Masuda, H., Tsujii, T., Okuno, T., Kihara, K., Goto, M., Azuma, H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  16. N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2. Tarumoto, T., Imagawa, S., Ohmine, K., Nagai, T., Higuchi, M., Imai, N., Suzuki, N., Yamamoto, M., Ozawa, K. Blood (2000) [Pubmed]
  17. Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis. Scarim, A.L., Arnush, M., Blair, L.A., Concepcion, J., Heitmeier, M.R., Scheuner, D., Kaufman, R.J., Ryerse, J., Buller, R.M., Corbett, J.A. Am. J. Pathol. (2001) [Pubmed]
  18. Nitric oxide and ocular blood flow in patients with IDDM. Schmetterer, L., Findl, O., Fasching, P., Ferber, W., Strenn, K., Breiteneder, H., Adam, H., Eichler, H.G., Wolzt, M. Diabetes (1997) [Pubmed]
  19. Beta-cell maturation leads to in vitro sensitivity to cytotoxins. Nielsen, K., Karlsen, A.E., Deckert, M., Madsen, O.D., Serup, P., Mandrup-Poulsen, T., Nerup, J. Diabetes (1999) [Pubmed]
  20. Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion. Takizawa, S., Fukuyama, N., Hirabayashi, H., Nakazawa, H., Shinohara, Y. J. Cereb. Blood Flow Metab. (1999) [Pubmed]
  21. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Casini, A., Ceni, E., Salzano, R., Biondi, P., Parola, M., Galli, A., Foschi, M., Caligiuri, A., Pinzani, M., Surrenti, C. Hepatology (1997) [Pubmed]
  22. Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi. Gantt, K.R., Goldman, T.L., McCormick, M.L., Miller, M.A., Jeronimo, S.M., Nascimento, E.T., Britigan, B.E., Wilson, M.E. J. Immunol. (2001) [Pubmed]
  23. Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina. Egashira, K., Katsuda, Y., Mohri, M., Kuga, T., Tagawa, T., Shimokawa, H., Takeshita, A. J. Am. Coll. Cardiol. (1996) [Pubmed]
  24. Nitric oxide promotes infectious bone resorption by enhancing cytokine-stimulated interstitial collagenase synthesis in osteoblasts. Lin, S.K., Kok, S.H., Kuo, M.Y., Lee, M.S., Wang, C.C., Lan, W.H., Hsiao, M., Goldring, S.R., Hong, C.Y. J. Bone Miner. Res. (2003) [Pubmed]
  25. Shear-induced increase in hydraulic conductivity in endothelial cells is mediated by a nitric oxide-dependent mechanism. Chang, Y.S., Yaccino, J.A., Lakshminarayanan, S., Frangos, J.A., Tarbell, J.M. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  26. Unresponsiveness of intrahepatic lymphocytes to bacterial superantigen: rapid development of suppressive Mac-1(high) cells in the mouse liver. Terabe, M., Shimizu, M., Mabuchi, A., Matui, S., Morikawa, H., Kaneda, K., Kakiuchi, T., Yokomuro, K. Hepatology (2000) [Pubmed]
  27. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. Cardounel, A.J., Xia, Y., Zweier, J.L. J. Biol. Chem. (2005) [Pubmed]
  28. Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine. Mühl, H., Dinarello, C.A. J. Immunol. (1997) [Pubmed]
  29. Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. John, S., Delles, C., Jacobi, J., Schlaich, M.P., Schneider, M., Schmitz, G., Schmieder, R.E. J. Am. Coll. Cardiol. (2001) [Pubmed]
  30. Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). Kim, Y.M., Talanian, R.V., Li, J., Billiar, T.R. J. Immunol. (1998) [Pubmed]
  31. Nitric oxide is a key determinant of group B streptococcus-induced murine macrophage apoptosis. Ulett, G.C., Adderson, E.E. J. Infect. Dis. (2005) [Pubmed]
  32. Interleukin-1 inhibits gamma interferon-induced bacteriostasis in human uroepithelial cells. Däubener, W., Hucke, C., Seidel, K., Hadding, U., MacKenzie, C.R. Infect. Immun. (1999) [Pubmed]
  33. The Inhibitory Effect of Leptin on Angiotensin II-Induced Vasoconstriction in Vascular Smooth Muscle Cells Is Mediated via a Nitric Oxide-Dependent Mechanism. Rodr??guez, A., Fortu??o, A., G??mez-Ambrosi, J., Zalba, G., D??ez, J., Fr??hbeck, G. Endocrinology (2007) [Pubmed]
  34. Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. Dearn, S., Rahman, M., Lewis, A., Ahmed, Z., Eggo, M.C., Ahmed, A. Mol. Med. (2000) [Pubmed]
  35. Impairment of the nitric oxide-mediated vasodilator response to mental stress in hypertensive but not in hypercholesterolemic patients. Cardillo, C., Kilcoyne, C.M., Cannon, R.O., Panza, J.A. J. Am. Coll. Cardiol. (1998) [Pubmed]
  36. Regulation of regional lung perfusion by nitric oxide. Rimeika, D., Nyrén, S., Wiklund, N.P., Koskela, L.R., Tørring, A., Gustafsson, L.E., Larsson, S.A., Jacobsson, H., Lindahl, S.G., Wiklund, C.U. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  37. Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis. Kuo, H.P., Wang, C.H., Huang, K.S., Lin, H.C., Yu, C.T., Liu, C.Y., Lu, L.C. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  38. Nitric oxide mediates early dysfunction of rat and mouse islets after transplantation. Stevens, R.B., Ansite, J.D., Mills, C.D., Lokeh, A., Rossini, T.J., Saxena, M., Brown, R.R., Sutherland, D.E. Transplantation (1996) [Pubmed]
  39. Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. Zadeh, M.S., Kolb, J.P., Geromin, D., D'Anna, R., Boulmerka, A., Marconi, A., Dugas, B., Marsac, C., D'Alessio, P. J. Leukoc. Biol. (2000) [Pubmed]
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