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Chemical Compound Review

Amoscanate     N-(4-isothiocyanatophenyl)-4- nitro-aniline

Synonyms: Amoscanato, Amoscanatum, Nithiocyamine, CHEMBL93385, CCRIS 4111, ...
 
 
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Disease relevance of GO 9333

 

High impact information on GO 9333

 

Chemical compound and disease context of GO 9333

 

Biological context of GO 9333

 

Anatomical context of GO 9333

 

Associations of GO 9333 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of GO 9333

References

  1. Efficacy of amoscanate against experimental schistosomal infections in monkeys. Crawford, K.A., Asch, H.L., Bruce, J.I., Bueding, E., Smith, E.R. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  2. Clinical evaluation of amoscanate in healthy male volunteers. Shapiro, T.A., Were, J.B., Talalay, P., Bueding, E., Rocco, L., Danso, K., Massof, R., Green, R., Mellits, E.D., Lietman, P.S. Am. J. Trop. Med. Hyg. (1986) [Pubmed]
  3. Clinical trials of a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), for the cure of hookworm infection. Doshi, J.C., Vaidya, A.B., Sen, H.G., Mankodi, N.A., Nair, C.N., Grewal, R.S. Am. J. Trop. Med. Hyg. (1977) [Pubmed]
  4. Parasite-specific inhibition of 5'-nucleotidase from Onchocerca volvulus and Dirofilaria immitis by the amoscanate-derivative CGP 8065. Walter, R.D., Albiez, E. Mol. Biochem. Parasitol. (1985) [Pubmed]
  5. In vivo effect of benzothiazole and amoscanate derivatives on the fine structure of adult Brugia spp. and Litomosoides carinii. Franz, M., Zahner, H., Mehlhorn, H., Striebel, H.P. Parasitol. Res. (1990) [Pubmed]
  6. Protection by antibiotics against experimental focal cholangitis produced in mice by a schistosomicidal isothiocyanate. Batzinger, R.P., Bueding, E., Popper, H. Hepatology (1981) [Pubmed]
  7. Schistosomiasis drug therapy and treatment considerations. Shekhar, K.C. Drugs (1991) [Pubmed]
  8. Conversion of amoscanate to a mutagenic metabolite in gnotobiotic mice implanted with Streptococcus equinus. Reddy, B.S., Batzinger, R.P., Molineaux, C.J., Bueding, E. Antimicrob. Agents Chemother. (1982) [Pubmed]
  9. Persistence of hepatic fibrosis and tissue eggs following treatment of Schistosoma japonicum infected mice. Cheever, A.W., Deb, S. Am. J. Trop. Med. Hyg. (1989) [Pubmed]
  10. Use of the DNA-repair host-mediated assay for determining the organ distribution of genotoxic factors in mice treated orally with nitro-aromatic compounds. Knasmüller, S., Kerklaan, P., Mohn, G.R. Mutat. Res. (1986) [Pubmed]
  11. Comparison of praziquantel, amoscanate and hexachloroparaxylol in clonorchiasis sinensis. Wang, Q.N., Liu, J.B., Liu, Y.H., Chen, R.X., Qiu, Z.D., Qu, Z.Q. Chin. Med. J. (1980) [Pubmed]
  12. Hymenolepis diminuta: effects of amoscanate on energy metabolism and ultrastructure. Nelson, N.F., Saz, H.J. Exp. Parasitol. (1983) [Pubmed]
  13. The immune response to a schistosomacide, amoscanate. I. Serum antibody responses. Barton, B.E., Levy, D.A. Journal of immunopharmacology. (1985) [Pubmed]
  14. Systolic time intervals in chronic anaemia before and after 4-isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540). A new anthelmintic. Mankodi, N.A., Vaidya, A.B., Pillay, M.G., Nargunde, H.S., Paul, T., Sheth, U.K., Kaul, C.L., Nair, K.G. The Journal of the Association of Physicians of India. (1981) [Pubmed]
  15. Electroretinographic assessment of early retinopathy in rats. Maertins, T., Kroetlinger, F., Sander, E., Pauluhn, J., Machemer, L. Arch. Toxicol. (1993) [Pubmed]
  16. Litomosoides carinii: mode of action in vitro of benzothiazole and amoscanate derivatives with antifilarial activity. Davies, K.P., Zahner, H., Köhler, P. Exp. Parasitol. (1989) [Pubmed]
  17. Schistosoma mansoni: tegumental surface alterations induced by subcurative doses of the schistosomicide amoscanate. Voge, M., Bueding, E. Exp. Parasitol. (1980) [Pubmed]
  18. Effects of amoscanate on the utilization of glucose by Brugia pahangi and Litomosoides carinii. Nelson, N.F., Saz, H.J. J. Parasitol. (1984) [Pubmed]
  19. Prevention of the mutagenic activation of an antischistosomal isothiocyanate in primates by an antibiotic. Batzinger, R.P., Bueding, E., Crawford, K., Bruce, J. Environmental mutagenesis. (1979) [Pubmed]
  20. Schistosoma haematobium: amoscanate and adult worm ultrastructure. Leitch, B., Probert, A.J. Exp. Parasitol. (1984) [Pubmed]
  21. Detectability and measurability of amoscanate in plasma by TLC and HPLC. Kofi-Tsekpo, W.M., Karekezi, C.W. Drugs under experimental and clinical research. (1988) [Pubmed]
  22. Histological changes elicited in Schistosoma japonicum infected rabbits following curative chemotherapy with 4-isothiocyano-4'-nitro-diphenylamine (C9333-Go/CGP 4540). Robinson, A., Lewert, R.M. Trans. R. Soc. Trop. Med. Hyg. (1981) [Pubmed]
 
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