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Chemical Compound Review

Ethmozine     ethyl N-[10-(3-morpholin-4...

Synonyms: Moracizin, MORICIZINE, Moracizina, Moracizine, Moracizinum, ...
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Disease relevance of MORICIZINE


High impact information on MORICIZINE


Chemical compound and disease context of MORICIZINE


Biological context of MORICIZINE


Anatomical context of MORICIZINE


Associations of MORICIZINE with other chemical compounds


Gene context of MORICIZINE


Analytical, diagnostic and therapeutic context of MORICIZINE


  1. Electrophysiologic response to moricizine in patients with sustained ventricular arrhythmias. Powell, A.C., Gold, M.R., Brooks, R., Garan, H., Ruskin, J.N., McGovern, B.A. Ann. Intern. Med. (1992) [Pubmed]
  2. Efficacy and risks of moricizine in inducible sustained ventricular tachycardia. Damle, R., Levine, J., Matos, J., Greenberg, S., Brooks, R., Frumkin, W., Goldberger, J., Kadish, A.H. Ann. Intern. Med. (1992) [Pubmed]
  3. Mechanism of interruption of atrial flutter by moricizine. Electrophysiological and multiplexing studies in the canine sterile pericarditis model of atrial flutter. Ortiz, J., Nozaki, A., Shimizu, A., Khrestian, C., Rudy, Y., Waldo, A.L. Circulation (1994) [Pubmed]
  4. Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction. A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST). Anderson, J.L., Platia, E.V., Hallstrom, A., Henthorn, R.W., Buckingham, T.A., Carlson, M.D., Carson, P.E. Circulation (1994) [Pubmed]
  5. Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy. Bigger, J.T., Rolnitzky, L.M., Steinman, R.C., Fleiss, J.L. J. Am. Coll. Cardiol. (1994) [Pubmed]
  6. The Cardiac Arrhythmia Suppression Trial: first CAST ... then CAST-II. Greene, H.L., Roden, D.M., Katz, R.J., Woosley, R.L., Salerno, D.M., Henthorn, R.W. J. Am. Coll. Cardiol. (1992) [Pubmed]
  7. Circadian pattern of arrhythmic death in patients receiving encainide, flecainide or moricizine in the Cardiac Arrhythmia Suppression Trial (CAST). Peters, R.W., Mitchell, L.B., Brooks, M.M., Echt, D.S., Barker, A.H., Capone, R., Liebson, P.R., Greene, H.L. J. Am. Coll. Cardiol. (1994) [Pubmed]
  8. Ethmozine (moricizine HCl) therapy for complex ventricular arrhythmias. Hession, M.J., Lampert, S., Podrid, P.J., Lown, B. Am. J. Cardiol. (1987) [Pubmed]
  9. Pharmacokinetics of moricizine in young patients. Rice, P.J., LeClair, I.O., Stone, W.L., Mehta, A.V. Journal of clinical pharmacology. (1995) [Pubmed]
  10. Drug interactions with Ethmozine (moricizine HCl). Kennedy, H.L., Wood, A.J., MacFarland, R.T. Am. J. Cardiol. (1987) [Pubmed]
  11. Antiarrhythmic efficacy of Ethmozine (moricizine HCl) compared with disopyramide and propranolol. Pratt, C.M., Butman, S.M., Young, J.B., Knoll, M., English, L.D. Am. J. Cardiol. (1987) [Pubmed]
  12. Efficacy, safety, hemodynamic effects, and pharmacokinetics of high-dose moricizine during short- and long-term therapy. Salerno, D.M., Sharkey, P.J., Granrud, G.A., Asinger, R.W., Hodges, M. Clin. Pharmacol. Ther. (1987) [Pubmed]
  13. Pharmacokinetic interactions between theophylline and other medication (Part I). Upton, R.A. Clinical pharmacokinetics. (1991) [Pubmed]
  14. Use-dependent block of Ca2+ current by moricizine in guinea-pig ventricular myocytes: a possible ionic mechanism of action potential shortening. Yamane, T., Sunami, A., Sawanobori, T., Hiraoka, M. Br. J. Pharmacol. (1993) [Pubmed]
  15. Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells. Maruyama, K., Kodama, I., Anno, T., Suzuki, R., Toyama, J. Br. J. Pharmacol. (1995) [Pubmed]
  16. The developmental electrophysiologic effects of moricizine HCl on the canine cardiac Purkinje fiber. Case, C.L., Ravin, R.R., Holani, R., Gillette, P.C., Hewett, K.W. Eur. J. Pharmacol. (1992) [Pubmed]
  17. Cardiac electrophysiologic effects of moricizine hydrochloride. Bigger, J.T. Am. J. Cardiol. (1990) [Pubmed]
  18. Distribution of moricizine in human blood: binding to plasma proteins and erythrocytes. Yang, J.M., Chan, K., Chiang, W.T. Therapeutic drug monitoring. (1990) [Pubmed]
  19. Complexation of moricizine with nicotinamide and evaluation of the complexation constants by various methods. Hussain, M.A., DiLuccio, R.C., Maurin, M.B. Journal of pharmaceutical sciences. (1993) [Pubmed]
  20. Pharmacokinetic interactions of moricizine and diltiazem in healthy volunteers. Shum, L., Pieniaszek, H.J., Robinson, C.A., Davidson, A.F., Widner, P.J., Benedek, I.H., Flamenbaum, W. Journal of clinical pharmacology. (1996) [Pubmed]
  21. Serum digoxin concentrations during ethmozine antiarrhythmic therapy. Kennedy, H.L., Sprague, M.K., Redd, R.M., Wiens, R.D., Blum, R.I., Buckingham, T.A. Am. Heart J. (1986) [Pubmed]
  22. Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A. Konishi, H., Morita, K., Minouchi, T., Yamaji, A. Pharmacology (2002) [Pubmed]
  23. Efficacy and safety of moricizine in patients with ventricular tachycardia: results of a placebo-controlled prospective long-term clinical trial. Pratt, C.M., Wierman, A., Seals, A.A., English, L., Leon, C., Young, J.B., Quinones, M.A., Roberts, R. Circulation (1986) [Pubmed]
  24. Moricizine. A review of its pharmacological properties, and therapeutic efficacy in cardiac arrhythmias. Fitton, A., Buckley, M.T. Drugs (1990) [Pubmed]
  25. Natural history of potentially lethal ventricular arrhythmias in patients treated with long-term antiarrhythmic drug therapy. Kennedy, H.L., Sprague, M.K., Homan, S.M., Seiler, S.M., Wiens, R.D., Janosik, D.L., Redd, R.M., Buckingham, T.A. Am. J. Cardiol. (1989) [Pubmed]
  26. Clinical pharmacokinetics of moricizine. Siddoway, L.A., Schwartz, S.L., Barbey, J.T., Woosley, R.L. Am. J. Cardiol. (1990) [Pubmed]
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