Disease relevance of NITROGEN DIOXIDE

• Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2 [1].
• Nitrogen dioxide and the gas fraction of welding fumes, a complex gas mixture which contains high concentrations of nitrogen dioxide, were tested for mutagenicity in Salmonella typhimurium tester strains, TA1535 and TA1538 [2].
• Nitrogen dioxide (NO2), an air pollutant produced by burning fossil fuels and a component of cigarette smoke, is thought to contribute to the pathogenesis of pulmonary diseases, such as emphysema [3].
• Nitrogen dioxide is formed during delivery of inhaled nitric oxide for the treatment of patients with pulmonary hypertension [4].
• Nitrogen dioxide pneumonitis in ice hockey players [5].

High impact information on NITROGEN DIOXIDE

• Nitrogen dioxide-induced expression of a 78 kDa protein in pulmonary artery endothelial cells [6].
• Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner [7].
• Nitrogen dioxide exposure: effects on airway and blood cells [8].
• Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein [9].
• Nitrogen dioxide induced a more modest drop in cell viability after 30 min exposure to 0.1%, while 0.005% and 0.05% were nontoxic [10].

Biological context of NITROGEN DIOXIDE

• Nitrogen dioxide (NO2) is a relatively insoluble, reactive gas that, on inhalation, generates a diverse array of pulmonary toxic effects [11].
• We propose that the nitration occurs in solution by transfer of a nitronium-like species from the active site on one superoxide dismutase dimer to the Tyr-108 of a second dimer [12].
• Nitrogen dioxide exposure activates gamma-glutamyl transferase gene expression in rat lung [13].
• Nitrogen dioxide (NO2), is a major air pollutant, that causes bronchoconstriction and bronchial hyperreactivity, and may also lead to damage and inflammation of the airway epithelium [14].
• Nitrogen dioxide (NO2) was selected for analysis as an indicator of traffic-related air pollution [15].

Anatomical context of NITROGEN DIOXIDE

• Nitrogen dioxide (NO2), an environmental oxidant, alters the plasma membrane structure and function of pulmonary artery endothelial cells through peroxidative injury [16].
• Nitrogen dioxide-induced reactive oxygen intermediates production by human alveolar macrophages and peripheral blood mononuclear cells [17].
• Nitrogen dioxide and pulmonary proteolytic enzymes. Effect on lung tissue and macrophages [18].
• Nitrogen dioxide and the erythrocyte redox state [19].
• Nitrogen dioxide exposure-induced mucosal pathology of the guinea pig trachea was studied [20].

Associations of NITROGEN DIOXIDE with other chemical compounds

• The calculated energy for separating peroxynitrous acid into hydroxide ion and nitronium ion is 13 kcal.mol-1 at pH 7 [21].
• We investigated possible mechanisms of tyrosine modification by various reactive nitrogen species, including ONOO-, 3-morpholinosydnonimine (SIN-1), and .NO2 [22].

Gene context of NITROGEN DIOXIDE

• Nitrogen dioxide also failed to elevate the levels of the mRNAs in non-smoker's cells but, again, tended to diminish the levels, particularly of IL-1 beta mRNA [23].
• Nitrogen dioxide has a significant impact on COPD hospitalization [24].
• Nitrogen dioxide exposure--influence on rat testes [25].
• Nitrogen dioxide is thought to have a role in PAH nitration in the Antarctic particulate matter [26].
• Nitrogen dioxide at 0.5 microl liter(-1) reduced RGR and NAR by 47% and 51%, respectively [27].

Analytical, diagnostic and therapeutic context of NITROGEN DIOXIDE

• Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction [28].
• Nitrogen dioxide, the oxides of nitrogen, and infants' health symptoms. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood [29].
• Nitrogen dioxide production in a nitric oxide inhalation system using the Servo Ventilator 900C [30].
• Nitrogen dioxide and respiratory illness in children. Part III: Quality assurance in an epidemiologic study [31].

References