Disease relevance of Hytuss

• Impairment of hemostasis in patients with severe hemophilia. Failure of diphenhydramine, chlorpromazine, and guaifenesin [1].
• Among women in the National Birth Defects Prevention Study, the use of acetaminophen, pseudoephedrine, diphenhydramine, and guaifenesin was higher during pregnancy than before pregnancy [2].
• Guaifenesin therapy in HIV+ patients led to a significant improvement in the SNOT-16 score (P < .05) [3].
• PROCEDURE: Guaifenesin (150 mg/kg of body weight, IV) was administered during a 5-minute period [4].
• Guaifenesin appears to be effective in managing HIV-infected patients with symptomatic rhinosinusitis and may be a useful adjunct for treating acute and chronic sinusitis in this population [5].

Psychiatry related information on Hytuss

• Psychosocial determinants of mothers' health behavior related to oresol use [6].

High impact information on Hytuss

• Twenty-three patients with severe hemophilia were given single or multiple doses of diphenhydramine hydrochloride, chlorpromazine hydrochloride, or guaifenesin to test their effects on hemostasis [1].
• Glyceryl guaiacolate inhibited aggregation one hour after ingestion but had no effect on bleeding time [7].
• BACKGROUND: Guaifenesin, a commonly used agent for the treatment of cough, is termed an expectorant since it is believed to alleviate cough discomfort by increasing sputum volume and decreasing its viscosity, thereby promoting effective cough [8].
• Drug releases of guaifenesin (mw 198.2), timolol (mw 332.4), sodium salicylate (mw 160.1) and FITC-dextran (mw 4400) from PDLLA and PEA films and microspheres were examined in PBS (pH 7.4, 37 degrees C) [9].
• After premedication with romifidine 100 microg kg(-1), anaesthesia was induced with ketamine 2.2 mg kg(-1) and maintained with halothane in oxygen (HA) or by an intravenous infusion of ketamine, guaiphenesin and romifidine (IV) [10].

Chemical compound and disease context of Hytuss

• Horses were anesthetized by way of 3 commonly used regimens, including xylazine (1.1 mg/kg of body weight) and ketamine hydrochloride (2.2 mg/kg); thiopental sodium (7.7 mg/kg), followed by halothane vaporized in oxygen; and thiopental sodium (2.5 g) in guaifenesin (100 mg/ml) solution given to effect, followed by halothane in oxygen [11].
• Six adult horses were anesthetized, using xylazine (2.2 mg/kg of body weight, IM), guaifenesin (50 mg/kg, IV), thiamylal Na (4.4 mg/kg, IV), and halothane (1.5 to 2% inspired) in 100% O2 [12].
• A separate group of 20 HIV+ patients participated in the second arm of the study and underwent saccharin testing before and after a 3-week course of guaifenesin or placebo [3].
• Ephedrine has been used as a stimulant and weight-loss product, guaifenesin as an expectorant and cough suppressant; both are found in combination in many antitussives and expectorants [13].
• A solution of 5% guaifenesin in a 5% dextrose solution or 5% guaifenesin in 0.9% saline produced minimal hemolysis in vitro [14].

Biological context of Hytuss

• Guaifenesin irreversibly disrupted mucociliary transport when applied directly to the frog palate [15].
• The administration of guaifenesin caused insignificant (P less than 0.05) changes in heart rate, respiratory rate, right atrial pressure, pulmonary arterial pressure, and cardiac output [16].
• Heart and respiratory rate, ECG, mean arterial blood pressure (MABP), cardiac index (CI), blood gases and plasma cortisol, ketamine and guaiphenesin were measured [17].
• Anesthesia was induced with IM administration of etorphine, and, to facilitate endotracheal intubation, muscle relaxation was achieved by IV administration of additional etorphine, acepromazine maleate, guaifenesin, and thiamylal sodium [18].
• The presence of guaifenesin in the sustained release tablet did not influence pseudoephedrine bioavailability [19].

Anatomical context of Hytuss

• Twenty-three of 26 (88 percent) patients receiving guaifenesin also reported reduction in sputum quantity compared to 15 of 24 (62.5 percent) receiving the vehicle (p = 0.07, Fisher exact test) [20].
• The hemolytic effect on bovine red blood cells of 5%, 10%, and 15% guaifenesin solutions in 5% dextrose, 0.9% saline (NaCl), or distilled water was determined in vitro at 2 plasma concentrations (250 micrograms/ml, 500 micrograms/ml) [14].
• Effects of 5% and 10% guaifenesin infusion on equine vascular endothelium [21].
• Neurotone therapy: a preliminary report of its effect on electrical activity of forebrain structures [22].
• Guaifenesin in water (100 mg/kg or a maximum dose of 50 grams) was infused into one jugular vein and an equal volume of 0.9% saline solution was infused into the other jugular vein [21].

Associations of Hytuss with other chemical compounds

• Simultaneous determination of acetaminophen, guaifenesin, pseudoephedrine, pholcodine, and paraben preservatives in cough mixture by high-performance liquid chromatography [23].
• Acetaminophen (I), guaifenesin (II), and dextromethorphan hydrobromide (III) were separated and quantitated simultaneously in cough syrup by high-pressure liquid chromatography [24].
• An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterol [15].
• Simultaneous determination of theophylline and guaiphenesin by third-derivative ultraviolet spectrophotometry and high-performance liquid chromatography [25].
• General anaesthesia was maintained in 40 horses by the continuous intravenous infusion of a mixture of 500 ml 10% guaifenesin solution, 1 g ketamine and 500 mg xylazine [26].

Gene context of Hytuss

• The electrochemical oxidation of Guaifenesin in a pharmaceutical formulation containing Guaifenesin has been carried out in Britton-Robinson buffer (BRB) (0.04 mol L-1) on platinum electrode [27].

Analytical, diagnostic and therapeutic context of Hytuss

• Guaifenesin effects on the guaiac test for occult blood [28].
• Isolation, partial identification and quantitative determination of four guaiphenesin glucuronides in plasma and urine of the horse by high-performance liquid chromatography [29].
• The determination of bifunctional compounds. IX. A selective reaction for the determination of guaifenesin in plasma by gas chromatography [30].
• HPLC determination of guaifenesin with selected medications on underivatized silica with an aqueous-organic mobile phase [31].
• CONCLUSIONS AND CLINICAL RELEVANCE: We concluded that guaifenesin synchronized the patterns of electroencephalograms [4].

References