Disease relevance of Sclerosol

• Peritonitis was produced by injecting a mixture containing 10(8) colony-forming units of bacteria and sterilized talcum into the peritoneum [1].
• Epidemiologic studies have suggested an increased risk for ovarian cancer associated with the use of talcum powder in genital hygiene, but the biologic credibility of the association has been questioned [2].
• Three IV drug abusers and the talcum powder abuser had histologic evidence of chronic hepatitis, most probably of viral etiology [3].
• Shaving and the use of chemical depilatories, deodorants, and talcum powder have been implicated in the initiation of hidradenitis suppurativa [4].
• The biochemical response of rabbit articular cartilage matrix to an induced talcum synovitis [5].

High impact information on Sclerosol

• Using a sterile technique, the pericardium was opened by way of a right thoracotomy, Teflon-coated, stainless steel wire electrodes were fixed to three selected sites on the atria and exteriorized, the atrial surfaces were generously dusted with talcum powder and a single layer of gauze was placed on the free left and right atrial walls [6].
• The catalytic machinery is very similar to that of transaldolase, which together with the overall structural similarity suggests that enzymes of the MipB/TALC subfamily are evolutionary related to the transaldolase family [7].
• The presence of talcum (125 mg) in the peritoneal cavity increased the risk of resistance after therapy [8].
• Mice were given a peritoneal challenge (10(8) cfu plus talcum) and treated by either antibiotic (50 mg/kg/dose, which produced similar antibiotic concentrations in peritoneal fluid in both cases) [9].
• The subjects included one patient who was a sandblaster (silica by inhalation), one patient who was a dental laboratory technician (silica and chromium-cobalt alloy by inhalation), one patient with inhalational talcum powder abuse, and four chronic intravenous (IV) drug abusers (talc by IV injection) [3].

Chemical compound and disease context of Sclerosol

• Granulomatous pneumonitis. A result of intrapleural instillation of quinacrine and talcum powder [10].

Anatomical context of Sclerosol

• Ninety-seven (52%) of the cancer patients habitually used talcum powder on the perineum, compared with 247 (46%) of the controls [11].
• No significant difference (P>0.05) in motility was observed between the control semen and the semen exposed to talcum powdered vinyl gloves [12].
• In this study, examinations for toxic effects of latex and vinyl gloves, used with and without talcum powder on boar spermatozoa, were performed [12].
• A clear histological picture of talcum powder within the vocal cord granulomata in one patient has been described [13].
• The effects of this chemical agent on the central nervous system is related to the percentage of HCP in talcum powder or solution for topical use [14].

Associations of Sclerosol with other chemical compounds

• The ejaculate was divided into 5 equal subsamples of 2 ml each, then randomly assigned to a control group, or treated with a 0.5-cm2 piece of latex or vinyl glove with or without talcum powder [15].

Gene context of Sclerosol

• The authors assessed histories of talcum powder use, tubal sterilization, and hysterectomy with ovarian conservation in 188 women in the San Francisco Bay Area with epithelial ovarian cancers diagnosed in 1983-1985 and in 539 control women [11].
• Mice were challenged (10(8) cfu plus talcum) intraperitoneally with one each of four strains of Ent. cloacae [16].
• STATISTICAL EVALUATION: General linear models for repeated measures (SAS GLM package) compared the interaction effects, group effects and time effects of findings in 19 patients receiving sitosterols with those in 18 patients receiving a placebo (talcum powder) [17].

Analytical, diagnostic and therapeutic context of Sclerosol

• The pattern of the observed changes in the levels of mRNAs for plasma proteins in the liver was independent of whether the acute inflammation was produced by subcutaneous injection of turpentine or intraperitoneal injection of a suspension of talcum [18].
• Parity, history of hormone replacement therapy or unilateral oopherectomy, and previous use of oral contraceptives or talcum powder are not significant predictors of CA125 concentrations (P > 0.05) [19].
• CONCLUSIONS: These results indicate that pleurodesis with iodized talcum slurry is a simple and inexpensive method with high efficacy in controlling malignant and non-malignant pleural effusions [20].
• We also carried out anaerobic bacterial counts for talcum powder as well as tests to detect some potentially hazardous bacteria in all tested samples [21].
• In each pig, one hemithorax underwent thoracoscopy and talc pleurodesis (TALC) [22].

References