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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

San Francisco

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Disease relevance of San Francisco


Psychiatry related information on San Francisco


High impact information on San Francisco

  • To assess the effect of cyclosporine on the use of hospital services, we studied 702 patients who received kidney transplants at the University of California, San Francisco, between July 1982 and June 1986 [9].
  • Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25 [10].
  • Blood samples were cultured from pet and impounded cats (N = 61) in the Greater San Francisco Bay Region, and R henselae was isolated from 41% (25/61) of these cats [11].
  • We investigated the thyroid and pituitary functions of six of the seven patients with nasopharyngeal carcinoma who had been previously treated with external radiation, and who were seen at the San Francisco Veterans Administration Hospital within a recent 18 month period [12].
  • Cervical fluids obtained from 78 premenopausal women seen between July 1983 and March 1984 at the University of California, San Francisco Dysplasia (and diethylstilbestrol) Clinic or in a private practice were tested for mutagenicity by means of the Ames-Salmonella microsomal test [13].

Chemical compound and disease context of San Francisco


Biological context of San Francisco


Anatomical context of San Francisco


Associations of San Francisco with chemical compounds

  • The variant G6PD, which appears to be unique, has been designated G6PD San Francisco. An unusual feature of the variant enzyme, susceptibility to inactivation by brief periods of dialysis, could be prevented by addition of 200 microM NADP to the dialysis solution [29].
  • We specifically studied the combination of cetuximab (Erbitux, C225; ImClone Systems, New York, NY) with either gefitinib (Iressa, ZD1839; AstraZeneca, Macclesfield, UK) or erlotinib (Tarceva, OSI-774; Genentech, South San Francisco, CA) across a variety of human cancer cells [30].
  • In San Francisco in 1987, only 17 out of 110 (15%) HIV-seropositive men without AIDS reported taking zidovudine [31].
  • SETTING: All methadone maintenance and 21-day methadone detoxification programs in San Francisco. PARTICIPANTS: A total of 2351 heterosexual IVDU, of whom 681 were seronegative at first visit and seen at least twice ('repeaters') [32].
  • Two forms of growth hormone were used in these studies, Protropin (Genentech, Inc., San Francisco, CA), a commercially available product that possesses a N-terminal methionine residue not found in the second form Nutropin (Genentech, Inc., San Francisco, CA), which, as yet, is not commercially available [33].

Gene context of San Francisco

  • Recently, HER2-targeting molecular therapy using trastuzumab (Herceptin; Genentech, Inc, South San Francisco, Calif) was revealed to be effective in advanced breast cancers overexpressing HER2 protein [34].
  • These angiogenesis inhibitors, include bevacizumab (Avastin, Genentech, Inc, South San Francisco, CA), which binds free VEGF [35].
  • Erlotinib HCl (Tarceva; Genentech, Inc, South San Francisco, CA) is an orally available, highly selective, reversible inhibitor of epidermal growth factor receptor (HER1/EGFR) tyrosine kinase [36].
  • We determined the hospital incidence (HI) and period prevalence (PP) of RA in African Colombians in Quibdo, Colombia, by using data collected at the Hospital San Francisco de Asis, a primary-to-tertiary care center [37].
  • Among 1194 FAP patients studied in two high risk registries in North America (Familial Gastrointestinal Cancer Registry, Toronto and University California, San Francisco), 16 (1.3%) unrelated patients with FAP associated thyroid cancers were identified [38].

Analytical, diagnostic and therapeutic context of San Francisco


  1. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Dean, M., Carrington, M., Winkler, C., Huttley, G.A., Smith, M.W., Allikmets, R., Goedert, J.J., Buchbinder, S.P., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R., O'Brien, S.J. Science (1996) [Pubmed]
  2. HIV infection and risk behaviors among heterosexuals in alcohol treatment programs. Avins, A.L., Woods, W.J., Lindan, C.P., Hudes, E.S., Clark, W., Hulley, S.B. JAMA (1994) [Pubmed]
  3. Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study. Eley, J.W., Hill, H.A., Chen, V.W., Austin, D.F., Wesley, M.N., Muss, H.B., Greenberg, R.S., Coates, R.J., Correa, P., Redmond, C.K. JAMA (1994) [Pubmed]
  4. Survival trends for patients with AIDS. Lemp, G.F., Payne, S.F., Neal, D., Temelso, T., Rutherford, G.W. JAMA (1990) [Pubmed]
  5. Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. Osmond, D.H., Buchbinder, S., Cheng, A., Graves, A., Vittinghoff, E., Cossen, C.K., Forghani, B., Martin, J.N. JAMA (2002) [Pubmed]
  6. Development of an instrument to measure disability in parenting activity among women with rheumatoid arthritis. Katz, P.P., Pasch, L.A., Wong, B. Arthritis Rheum. (2003) [Pubmed]
  7. Human T cell leukemia virus (HTLV-I/II) serodiagnostic testing: disparate results among a cohort of intravenous drug users. Aboulafia, D.M., Feigal, E., Vranzian, K., Bennett, C., Blattner, W., Moss, A., Slamon, D. AIDS Res. Hum. Retroviruses (1993) [Pubmed]
  8. Gender differences in sexual and injection risk behavior among active young injection drug users in San Francisco (the UFO Study). Evans, J.L., Hahn, J.A., Page-Shafer, K., Lum, P.J., Stein, E.S., Davidson, P.J., Moss, A.R. Journal of urban health : bulletin of the New York Academy of Medicine. (2003) [Pubmed]
  9. The effect of cyclosporine on the use of hospital resources for kidney transplantation. Showstack, J., Katz, P., Amend, W., Bernstein, L., Lipton, H., O'Leary, M., Bindman, A., Salvatierra, O. N. Engl. J. Med. (1989) [Pubmed]
  10. Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS. Kalyanaraman, V.S., Cabradilla, C.D., Getchell, J.P., Narayanan, R., Braff, E.H., Chermann, J.C., Barré-Sinoussi, F., Montagnier, L., Spira, T.J., Kaplan, J. Science (1984) [Pubmed]
  11. Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir. Koehler, J.E., Glaser, C.A., Tappero, J.W. JAMA (1994) [Pubmed]
  12. Primary and secondary hypothyroidism in nasopharyngeal carcinoma. Rosenthal, M.B., Goldfine, I.D. JAMA (1976) [Pubmed]
  13. Mutagenic mucus in the cervix of smokers. Holly, E.A., Petrakis, N.L., Friend, N.F., Sarles, D.L., Lee, R.E., Flander, L.B. J. Natl. Cancer Inst. (1986) [Pubmed]
  14. Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era. Martin, J.N., Rose, D.A., Hadley, W.K., Perdreau-Remington, F., Lam, P.K., Gerberding, J.L. J. Infect. Dis. (1999) [Pubmed]
  15. Dapsone treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Mills, J., Leoung, G., Medina, I., Hopewell, P.C., Hughes, W.T., Wofsy, C. Antimicrob. Agents Chemother. (1988) [Pubmed]
  16. Decreased serum dehydroepiandrosterone is associated with an increased progression of human immunodeficiency virus infection in men with CD4 cell counts of 200-499. Jacobson, M.A., Fusaro, R.E., Galmarini, M., Lang, W. J. Infect. Dis. (1991) [Pubmed]
  17. Progression and clinical outcome of infection due to human immunodeficiency virus. Lifson, A.R., Hessol, N.A., Rutherford, G.W. Clin. Infect. Dis. (1992) [Pubmed]
  18. Social class and the black/white crossover in the age-specific incidence of breast cancer: a study linking census-derived data to population-based registry records. Krieger, N. Am. J. Epidemiol. (1990) [Pubmed]
  19. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Mann, M., Sheng, H., Shao, J., Williams, C.S., Pisacane, P.I., Sliwkowski, M.X., DuBois, R.N. Gastroenterology (2001) [Pubmed]
  20. Bioavailability of organic matter in a highly disturbed estuary: the role of detrital and algal resources. Sobczak, W.V., Cloern, J.E., Jassby, A.D., Müller-Solger, A.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  21. The primosomal protein n' of Escherichia coli is a DNA helicase. Lasken, R.S., Kornberg, A. J. Biol. Chem. (1988) [Pubmed]
  22. Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. Tang, J., Shelton, B., Makhatadze, N.J., Zhang, Y., Schaen, M., Louie, L.G., Goedert, J.J., Seaberg, E.C., Margolick, J.B., Mellors, J., Kaslow, R.A. J. Virol. (2002) [Pubmed]
  23. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. Huang, L., Beard, C.B., Creasman, J., Levy, D., Duchin, J.S., Lee, S., Pieniazek, N., Carter, J.L., del Rio, C., Rimland, D., Navin, T.R. J. Infect. Dis. (2000) [Pubmed]
  24. Outbreak of Burkitt's-like lymphoma in homosexual men. Ziegler, J.L., Drew, W.L., Miner, R.C., Mintz, L., Rosenbaum, E., Gershow, J., Lennette, E.T., Greenspan, J., Shillitoe, E., Beckstead, J., Casavant, C., Yamamoto, K. Lancet (1982) [Pubmed]
  25. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Chang, K., Adleman, N.E., Dienes, K., Simeonova, D.I., Menon, V., Reiss, A. Arch. Gen. Psychiatry (2004) [Pubmed]
  26. Circulating red cells usually remain of host origin after bone marrow transplantation for severe combined immunodeficiency. Brady, K.A., Cowan, M.J., Leavitt, A.D. Transfusion (1996) [Pubmed]
  27. The pulmonary manifestations of AIDS-related non-Hodgkin's lymphoma. Eisner, M.D., Kaplan, L.D., Herndier, B., Stulbarg, M.S. Chest (1996) [Pubmed]
  28. The clinical spectrum of patients with aneurysms of the ascending aorta. Eisenberg, M.J., Rice, S.A., Paraschos, A., Caputo, G.R., Schiller, N.B. Am. Heart J. (1993) [Pubmed]
  29. G6PD San Francisco: a new variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia. Mentzer, W.C., Warner, R., Addiego, J., Smith, B., Walter, T. Blood (1980) [Pubmed]
  30. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Huang, S., Armstrong, E.A., Benavente, S., Chinnaiyan, P., Harari, P.M. Cancer Res. (2004) [Pubmed]
  31. Use of therapeutic and prophylactic drugs for AIDS by homosexual and bisexual men in three US cities. Holmberg, S.D., Conley, L.J., Buchbinder, S.P., Judson, F.N., Bush, T.J., Katz, M.H., Penley, K.A., Hershow, R.C. AIDS (1993) [Pubmed]
  32. HIV seroconversion in intravenous drug users in San Francisco, 1985-1990. Moss, A.R., Vranizan, K., Gorter, R., Bacchetti, P., Watters, J., Osmond, D. AIDS (1994) [Pubmed]
  33. Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Gilpin, D.A., Barrow, R.E., Rutan, R.L., Broemeling, L., Herndon, D.N. Ann. Surg. (1994) [Pubmed]
  34. Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein. Ogawa, T., Nagashima, Y., Wada, H., Akimoto, K., Chiba, Y., Nagatani, T., Inayama, Y., Yao, M., Aoki, I., Ikezawa, Z. Hum. Pathol. (2005) [Pubmed]
  35. Angiogenesis inhibitors in the treatment of colorectal cancer. Iqbal, S., Lenz, H.J. Semin. Oncol. (2004) [Pubmed]
  36. Preclinical studies with Erlotinib (Tarceva). Akita, R.W., Sliwkowski, M.X. Semin. Oncol. (2003) [Pubmed]
  37. Rheumatoid arthritis in African Colombians from Quibdo. Anaya, J.M., Correa, P.A., Mantilla, R.D., Jimenez, F., Kuffner, T., McNicholl, J.M. Semin. Arthritis Rheum. (2001) [Pubmed]
  38. Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. Truta, B., Allen, B.A., Conrad, P.G., Kim, Y.S., Berk, T., Gallinger, S., Bapat, B., Terdiman, J.P., Sleisenger, M.H. Fam. Cancer (2003) [Pubmed]
  39. Effects on quality of life of combined trastuzumab and chemotherapy in women with metastatic breast cancer. Osoba, D., Slamon, D.J., Burchmore, M., Murphy, M. J. Clin. Oncol. (2002) [Pubmed]
  40. Use of beta 2-microglobulin level and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Anderson, R.E., Lang, W., Shiboski, S., Royce, R., Jewell, N., Winkelstein, W. Arch. Intern. Med. (1990) [Pubmed]
  41. Outcomes of intensive care for patients with human immunodeficiency virus infection. Nickas, G., Wachter, R.M. Arch. Intern. Med. (2000) [Pubmed]
  42. Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer. Hortobagyi, G.N. Semin. Oncol. (2001) [Pubmed]
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