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Chemical Compound Review

Bufenine     4-[1-hydroxy-2-(4- phenylbutan-2...

Synonyms: Bufenina, Buphenin, nylidrin, Arlidin, Buphenine, ...
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Disease relevance of nylidrin


High impact information on nylidrin


Chemical compound and disease context of nylidrin


Biological context of nylidrin


Anatomical context of nylidrin


Associations of nylidrin with other chemical compounds


Gene context of nylidrin

  • At the age of 12 months the children in the indomethacin group showed poor outcome (death or severe BPD and/or CP and/or severe ROP) in 23% and the children in the nylidrin group in 5% (p = 0.039, Fisher Exact Test) [18].
  • Nylidrin (RHC 3432-A) has been investigated for its antiallergic activity in three in vitro models [19].

Analytical, diagnostic and therapeutic context of nylidrin


  1. Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin. Mittag, T.W., Tormay, A., Messenger, M., Podos, S.M. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  2. Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. Eronen, M., Pesonen, E., Kurki, T., Teramo, K., Ylikorkala, O., Hallman, M. J. Pediatr. (1994) [Pubmed]
  3. Vasocilators in the canine mesenteric circulation. Evaluation of a potential aid in the diagnosis of gastrointestinal bleeding. Sovak, M., Rösch, J., Lakin, R.C. Investigative radiology. (1975) [Pubmed]
  4. Treatment of imminent premature labour. Castrén, O., Gummerus, M., Saarikoski, S. Acta obstetricia et gynecologica Scandinavica. (1975) [Pubmed]
  5. Nylidrin: a potent anti-hypertensive agent in hypertensive rats. Yen, T.T., Pearson, D.V. Res. Commun. Chem. Pathol. Pharmacol. (1979) [Pubmed]
  6. Subtype-selective antagonism of NMDA receptors by nylidrin. Whittemore, E.R., Ilyin, V.I., Konkoy, C.S., Woodward, R.M. Eur. J. Pharmacol. (1997) [Pubmed]
  7. Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin. Kurki, T., Laatikainen, T., Salminen-Lappalainen, K., Ylikorkala, O. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  8. The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study. Eronen, M., Pesonen, E., Kurki, T., Ylikorkala, O., Hallman, M. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  9. A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Kurki, T., Eronen, M., Lumme, R., Ylikorkala, O. Obstetrics and gynecology. (1991) [Pubmed]
  10. Central cardiovascular effects of nylidrin (buphenine). Fichtl, B., Felix, W. Eur. J. Pharmacol. (1980) [Pubmed]
  11. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. Kurki, T., Viinikka, L., Ylikorkala, O. Am. J. Obstet. Gynecol. (1992) [Pubmed]
  12. Effects of beta-agonists on b- and c-waves implicit for adrenergic mechanisms in cat retina. Niemeyer, G., Cottier, D., Gerber, U. Documenta ophthalmologica. Advances in ophthalmology. (1987) [Pubmed]
  13. Topical nylidrin and aqueous humor dynamics in rabbits and monkeys. Sobel, L., Serle, J.B., Podos, S.M., Krupin, T., Chubak, G.S., Yablonski, M.E., Severin, C. Arch. Ophthalmol. (1983) [Pubmed]
  14. Effects of buphenine (nylidrin) on the perfused mammalian eye. Niemeyer, G., Cottier, D., Resch, H. Graefes Arch. Clin. Exp. Ophthalmol. (1987) [Pubmed]
  15. Effects of isoxuprine and nylidrin on adrenoreceptors in rat vas deferens. Abel, P.W., Fox, A.W., Minneman, K.P. Journal of autonomic pharmacology. (1985) [Pubmed]
  16. The effects of beta-adrenergic agonists on cone systems in the cat eye. Uji, Y., Niemeyer, G., Gerber, U. Documenta ophthalmologica. Advances in ophthalmology. (1988) [Pubmed]
  17. Buphenine and threatened abortion. Soltan, M.H. Eur. J. Obstet. Gynecol. Reprod. Biol. (1986) [Pubmed]
  18. Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin. Salokorpi, T., Eronen, M., von Wendt, L. Neuropediatrics. (1996) [Pubmed]
  19. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. Khandwala, A., Coutts, S.M., Weinryb, I. Int. Arch. Allergy Appl. Immunol. (1983) [Pubmed]
  20. The hemodynamic effects of antenatal indomethacin and a beta-sympathomimetic agent on the fetus and the newborn: a randomized study. Eronen, M. Pediatr. Res. (1993) [Pubmed]
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