Disease relevance of nylidrin

• Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin [1].
• If preterm labor recurred, all parturient patients were treated with nylidrin [2].
• A large and short vasodilation was produced with tolazoline and nylidrin, but both agents increased VR of the postcapillary segment and caused transient hypotension and arrhythmias, nylidrin's side effects were smaller [3].
• Taking a minimum birth weight of 2500 g as the criteria of successful treatment, the success rate in the placebo group was 71%, in the Nylidrin hydrochloride group 86%, the Isoxuprine hydrochloride group 75% and the alcohol group 70% [4].
• In normotensive rats of Wistar/Kyoto strain (WKY) and Holtzman strain, nylidrin at 5 or 10 mg/kg, s.c., produced a transient hypotensive effect which lasted less than an hour and tachycardia that persisted for several hours [5].

High impact information on nylidrin

• Pirbuterol and nylidrin, both purported sympathomimetic amines, reduced intraocular pressure (IOP) when given topically (50 microliter, 0.1%) to albino rabbits [1].
• Nylidrin was a potent (IC50 = 0.18 microM) antagonist of NR1A/2B receptors expressed in Xenopus oocytes and was at least 150-fold weaker against NR1A/2A and NR1A/2C receptors [6].
• The role of corticotrophin-releasing hormone (CRH) in preterm labour was studied in 23 women in preterm labour at between 26 and 33 weeks gestation who were randomly allocated to receive treatment with indomethacin (n = 11) or with nylidrin a beta-sympathomimetic agent (n = 12) [7].
• Both systolic and diastolic velocities in the ductus increased after administration of indomethacin indicating constriction in nine fetuses, and exceeded the corresponding velocities in the fetuses of the nylidrin group (p = 0.001) [8].
• These findings indicate that indomethacin, not nylidrin, causes transient constriction of the ductus arteriosus and the constrictive response increases with the gestational age [8].

Chemical compound and disease context of nylidrin

• Preterm labor was arrested for 24, 48, and 72 hours in 100, 96, and 90%, respectively, of subjects in the indomethacin group, compared with 100, 76, and 73% of women in the nylidrin group; the difference was significant (P less than .05) at 48 hours [9].
• Propranolol reversed both effects on blood pressure and heart rate by nylidrin, whereas atenolol, a specific cardiac beta 1 blocker, only blocked or reversed the tachycardia caused by nylidrin but did not block the anti-hypertensive effect of the compound [5].

Biological context of nylidrin

• Cerebroventricular perfusion of nylidrin also decreased blood pressure and inhibited or modified cardiovascular reflexes [10].
• STUDY DESIGN: Thirty-three women in preterm labor between 25 and 34 weeks of gestation were studied before, during, and after treatment with indomethacin (n = 16) or nylidrin (n = 17) [11].
• Standing potential, light peak, intraocular pressure, vascular resistance, and diameter of or retinal vessels showed no consistent changes under nylidrin [12].

Anatomical context of nylidrin

• It is concluded that oxygen or possibly nylidrin are suitable agents should an intermittently bleeding mesenteric artery be dilated for diagnostic purposes prior to angiography [3].
• Topical nylidrin and aqueous humor dynamics in rabbits and monkeys [13].
• The injection of small doses of nylidrin into the vertebral artery lowered blood pressure in chloralose-anesthetized cats [10].
• Consequently, we studied the action of 4.5-120 microM buphenine in isolated, arterially perfused cat eyes, and then used light-evoked electrical signals, perfusion flow rates and the diameters of the retinal vessels as parameters for the drug's effect [14].
• Effects of isoxuprine and nylidrin on adrenoreceptors in rat vas deferens [15].

Associations of nylidrin with other chemical compounds

• Topical administration of nylidrin hydrochloride lowered intraocular pressure in both albino rabbits and cynomologus monkeys [13].
• The effects of the beta-adrenergic agonist nylidrin and the beta 2-adrenergic agonist clenbuterol on electroretinogram and optic nerve response were studied in the isolated and arterially perfused, light-adapted cat eye [16].
• Group 1 of eighty-five patients were treated with the uterine muscle relaxant, buphenine hydrochloride [17].

Gene context of nylidrin

• At the age of 12 months the children in the indomethacin group showed poor outcome (death or severe BPD and/or CP and/or severe ROP) in 23% and the children in the nylidrin group in 5% (p = 0.039, Fisher Exact Test) [18].
• Nylidrin (RHC 3432-A) has been investigated for its antiallergic activity in three in vitro models [19].

Analytical, diagnostic and therapeutic context of nylidrin

• In the nylidrin group, no fetus had ductal constriction or TR [20].

References