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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Prone Position

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Disease relevance of Prone Position


High impact information on Prone Position

  • Nine infants with documented gastroesophageal reflux participated in 18 paired two-hour postprandial trials in an infant seat and in the horizontal prone position [5].
  • CONCLUSION: Maintaining a prone position for 1 hour after an intralumbar dose increased the peak methotrexate concentration and drug exposure in ventricular CSF [6].
  • Oxygenation response to a recruitment maneuver during supine and prone positions in an oleic acid-induced lung injury model [7].
  • In the presence of abdominal distension, the prone position increased Pa O2 by 26 +/- 18 mm Hg (p < 0.01) and decreased AaPO2 (p < 0.05) and V A/Q heterogeneity as measured by the log standard deviation of the perfusion distribution (p < 0.01) and the arterial-alveolar difference area (p < 0.05) [8].
  • Prone position (T3) resulted in an increase in PO2/FI(O2) (193 +/- 83 mm Hg, p < 0.003 versus T0) [9].

Biological context of Prone Position


Anatomical context of Prone Position


Associations of Prone Position with chemical compounds

  • Hydroxyl free radical formation was significantly higher in the veins of dogs in an upright position than in those in a prone position [18].
  • 2. We therefore determined the dynamics of intramuscular [phosphocreatine] ([PCr]) simultaneously with those of .V(O2) in seven males who performed two consecutive bouts of high-intensity square-wave, knee-extensor exercise in the prone position for 6 min with a 6 min rest interval [19].
  • TWelve of these patients had massive, bilateral disturbance of intrarenal hippurate transport in the standing position; hippurate transport was normal in the prone position [20].
  • METHODS: A polystyrene bowel displacement standard mold was created and added to a customized vacuum cushion (Vac Lok) formed around the abdomen and legs of each patient in the prone position [21].
  • CONCLUSION: Perflubron is more uniformly dispersed when dosed in a rotational fashion with alternation between supine and prone position during incremental dosing [22].

Gene context of Prone Position

  • Computed tomography (CT) scans were taken in the prone position, both with and without the SBDS [23].
  • Thirty-two consecutive patients were studied 1 h before, 1 and 4 h during and 1 h after placing in a prone position with PaO2/F(I)O2 of 103 +/- 28, 158 +/- 62, 159 +/- 59, and 128 +/- 52, respectively (ANOVA, p < 0.001) [24].
  • The only variable that was associated with high tryptase values was prone position at death (P < or = 0.05 ) [25].
  • Mean (+/-SD) baseline twitch Pga measured with the subjects in the prone position at T10 was 23.5 +/- 5.4 cmH2O [26].
  • To evaluate the impact of oxygen therapy on positional effect in gas exchange, arterial blood gas levels were measured in the supine and prone positions in some PAP patients while breathing 40% oxygen [27].

Analytical, diagnostic and therapeutic context of Prone Position


  1. Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome. Broccard, A.F., Shapiro, R.S., Schmitz, L.L., Ravenscraft, S.A., Marini, J.J. Crit. Care Med. (1997) [Pubmed]
  2. Beneficial effects of the prone position on the incidence of barotrauma in oleic acid-induced lung injury under continuous positive pressure ventilation. Du, H.L., Yamada, Y., Orii, R., Suzuki, S., Sawamura, S., Suwa, K., Hanaoka, K. Acta anaesthesiologica Scandinavica. (1997) [Pubmed]
  3. Recruitment of intercostal muscle activity during hypercapnia in kittens. Watchko, J.F., Klesh, K.W., O'Day, T.L., Guthrie, R.D. Pediatr. Pulmonol. (1988) [Pubmed]
  4. Detection of amiodarone-induced pulmonary toxicity in supine and prone positions: high-resolution computed tomography study. Oyama, N., Oyama, N., Yokoshiki, H., Kamishima, T., Nambu, T., Tsutsui, H., Miyasaka, K. Circ. J. (2005) [Pubmed]
  5. The infant seat as treatment for gastroesophageal reflux. Orenstein, S.R., Whitington, P.F., Orenstein, D.M. N. Engl. J. Med. (1983) [Pubmed]
  6. Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration. Blaney, S.M., Poplack, D.G., Godwin, K., McCully, C.L., Murphy, R., Balis, F.M. J. Clin. Oncol. (1995) [Pubmed]
  7. Oxygenation response to a recruitment maneuver during supine and prone positions in an oleic acid-induced lung injury model. Cakar, N., der Kloot, T.V., Youngblood, M., Adams, A., Nahum, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  8. Pulmonary gas exchange improves in the prone position with abdominal distension. Mure, M., Glenny, R.W., Domino, K.B., Hlastala, M.P. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  9. Respective and combined effects of prone position and inhaled nitric oxide in patients with acute respiratory distress syndrome. Papazian, L., Bregeon, F., Gaillat, F., Thirion, X., Gainnier, M., Gregoire, R., Saux, P., Gouin, F., Jammes, Y., Auffray, J.P. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  10. Vulnerability of respiratory control in healthy preterm infants placed supine. Martin, R.J., DiFiore, J.M., Korenke, C.B., Randal, H., Miller, M.J., Brooks, L.J. J. Pediatr. (1995) [Pubmed]
  11. Influence of the prone position on propofol pharmacokinetics. Takizawa, D., Hiraoka, H., Nakamura, K., Yamamoto, K., Horiuchi, R. Anaesthesia. (2004) [Pubmed]
  12. Haemodynamic effects of the prone position: a comparison of propofol total intravenous and inhalation anaesthesia. Sudheer, P.S., Logan, S.W., Ateleanu, B., Hall, J.E. Anaesthesia. (2006) [Pubmed]
  13. Deliberate arterial hypotension does not reduce intraocular pressure in pigs. Jantzen, J.P., Hennes, H.J., Rochels, R., Wallenfang, T. Anesthesiology (1992) [Pubmed]
  14. Anesthetic management of a patient in prone position with a drill bit penetrating the spinal canal at C1-C2, using a laryngeal mask. Valero, R., Serrano, S., Adalia, R., Tercero, J., Blasi, A., Sánchez-Etayo, G., Martínez, G., Caral, L., Ibáñez, G. Anesth. Analg. (2004) [Pubmed]
  15. Angiotensin II formation and endothelin clearance in ARDS patients in supine and prone positions. Wenz, M., Hoffmann, B., Bohlender, J., Kaczmarczyk, G. Intensive care medicine. (2000) [Pubmed]
  16. Efficacy of extracorporeal shockwave lithotripsy with patients rotated supine or rotated prone for treating ureteral stones: a case-control study. Hara, N., Koike, H., Bilim, V., Takahashi, K., Nishiyama, T. J. Endourol. (2006) [Pubmed]
  17. Improving arteriography of the pancreas. Damascelli, B., Garbagnati, F., Ceglia, E., Milella, M. Surgery, gynecology & obstetrics. (1980) [Pubmed]
  18. Increase of hydroxyl free radical formation during venous stasis of dogs. Delbarre, B., Delbarre, G., Calinon, F. Free Radic. Biol. Med. (1993) [Pubmed]
  19. Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. Rossiter, H.B., Ward, S.A., Kowalchuk, J.M., Howe, F.A., Griffiths, J.R., Whipp, B.J. J. Physiol. (Lond.) (2001) [Pubmed]
  20. Hypertension associated with massive, bilateral, posture-dependent renal dysfunction. Clorius, J.H., Schmidlin, P., Raptou, E., Huber, W., Georgi, P. Radiology. (1981) [Pubmed]
  21. Dislocation of small bowel volume within box pelvic treatment fields, using new "up down table" device. Capirci, C., Polico, C., Mandoliti, G. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  22. Optimizing intrapulmonary perfluorocarbon distribution: fluoroscopic comparison of mode of ventilation and body position. Bateman, S.T., Doctor, A., Price, B., Murphy, M.A., Thompson, J.E., Zurakowski, D., Taylor, G.A., Arnold, J.H. Crit. Care Med. (2001) [Pubmed]
  23. Small bowel displacement system-assisted intensity-modulated radiotherapy for cervical cancer. Huh, S.J., Kang, M.K., Han, Y. Gynecol. Oncol. (2004) [Pubmed]
  24. Prone position in mechanically ventilated patients with severe acute respiratory failure. Chatte, G., Sab, J.M., Dubois, J.M., Sirodot, M., Gaussorgues, P., Robert, D. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  25. Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxia or artefact? Edston, E., Gidlund, E., Wickman, M., Ribbing, H., Van Hage-Hamsten, M. Clin. Exp. Allergy (1999) [Pubmed]
  26. Abdominal muscle fatigue after maximal ventilation in humans. Kyroussis, D., Mills, G.H., Polkey, M.I., Hamnegard, C.H., Koulouris, N., Green, M., Moxham, J. J. Appl. Physiol. (1996) [Pubmed]
  27. Effect of body position on gas exchange in patients with idiopathic pulmonary alveolar proteinosis: no benefit of prone positioning. Lin, F.C., Chen, Y.C., Chang, H.I., Chang, S.C. Chest (2005) [Pubmed]
  28. Minimization of small bowel volume within treatment fields utilizing customized "belly boards". Shanahan, T.G., Mehta, M.P., Bertelrud, K.L., Buchler, D.A., Frank, L.E., Gehring, M.A., Kubsad, S.S., Utrie, P.C., Kinsella, T.J. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  29. Influence of carbon dioxide on respiratory function during posterior retroperitoneoscopic adrenalectomy in prone position. Sasagawa, I., Suzuki, H., Izumi, T., Shoji, N., Nakada, T., Takaoka, S., Miura, Y., Hoshi, H., Amagasa, S., Horikawa, H. Eur. Urol. (1999) [Pubmed]
  30. Sidestream end-tidal capnometry as related to infant's position and maturation. Kugelman, A., Bilker, A., Bader, D., Cohen, A., Tirosh, E. Acta Paediatr. (2002) [Pubmed]
  31. Brachial plexus birth injuries: anaesthesia for surgical nerve reconstruction and preoperative myelography and computed tomographic myelography. Hazama, A., Kinouchi, K., Kitamura, S., Fukumitsu, K. Paediatric anaesthesia. (1999) [Pubmed]
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