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Chemical Compound Review

CID566     ethanoic acid; phenylmercury

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Disease relevance of phenylmercuric acetate


High impact information on phenylmercuric acetate

  • Transgenic plants expressing merBpe grew vigorously on a wide range of concentrations of monomethylmercuric chloride and phenylmercuric acetate [6].
  • Phenylmercuric acetate did not induce mer operon expression when the MerRNS was used in the assay [7].
  • The assignment of these effects to the carboxylate moiety of p-(chloromercuri)benzoate is brought out by the observation that the introduction in the 3-fold channel of the benzene ring only by means of phenylmercuric acetate has no effect on the initial iron uptake kinetics and on the spectroscopic properties of the Fe(III)-apoferritin complex [8].
  • The structural basis for induction of the mercury resistance operon with inorganic mercury and with the organomercurial compound phenylmercuric acetate was addressed by DNA sequencing analysis and by lac fusion transcription experiments regulated by merR in trans from broad-spectrum-resistance plasmid pDU1358 (Hg2+ and phenylmercury responding) [9].
  • In addition, these four plasmids conferred resistance to merbromin, phenylmercury acetate, and mercuric ions, had almost identical restriction endonuclease cleavage patterns, and encoded degradation of m-chlorobenzoate [10].

Biological context of phenylmercuric acetate


Anatomical context of phenylmercuric acetate


Associations of phenylmercuric acetate with other chemical compounds


Gene context of phenylmercuric acetate

  • Two other heavy metal compounds, AgNO3 and phenylmercuric acetate, caused a similar increase in TF activity [21].
  • Addition of mercuric ions and phenylmercuric acetate prevented the binding of MerR [22].
  • Thioredoxin reductase (TrxR) from Escherichia coli, the mutant proteins E159Y and C138S, and the mutant protein C138S treated with phenylmercuric acetate were reconstituted with [U-(13)C(17),U-(15)N(4)]FAD and analysed, in their oxidized and reduced states, by (13)C-, (15)N- and (31)P-NMR spectroscopy [23].
  • The magnitude of component R was markedly reduced by phenylmercuric acetate, suggesting the participation of ferredoxin and ferredoxin-NADP oxidoreductase in the mechanism of the field formation responsible for this component [24].
  • Nursing leader Rita Celmer: the spirit of emergency nursing. Interview by Mary Bailey [25].

Analytical, diagnostic and therapeutic context of phenylmercuric acetate

  • Patients with suspected illness due to mercury in dental amalgam were classified as tolerant or intolerant depending on their psychosomatic responses following in vivo epicutaneous provocation with low doses (patch test doses) of metallic mercury and phenylmercuric acetate [26].
  • Between August 1983 and August 1992, 1995 women aged 20-43 years were fitted with 2736 copper intrauterine contraceptive devices (MLCu250, MLCu375, Nova-T, Gravigard, Anticon) [27].


  1. Cloning and expression in Escherichia coli of chromosomal mercury resistance genes from a Bacillus sp. Wang, Y., Mahler, I., Levinson, H.S., Halvorson, H.O. J. Bacteriol. (1987) [Pubmed]
  2. Translocatable resistance to mercuric and phenylmercuric ions in soil bacteria. Radford, A.J., Oliver, J., Kelly, W.J., Reanney, D.C. J. Bacteriol. (1981) [Pubmed]
  3. NMR analysis of quinocycline antibiotics: structure determination of kosinostatin, an antitumor substance from Micromonospora sp. TP-A0468. Igarashi, Y., Higuchi, H., Oki, T., Furumai, T. J. Antibiot. (2002) [Pubmed]
  4. Contact urticaria syndrome due to phenylmercuric acetate. Torresani, C., Caprari, E., Manara, G.C. Contact Derm. (1993) [Pubmed]
  5. Chronic phenylmercuric acetate toxicity in a horse. Roberts, M.C., Seawright, A.A., Ng, J.C. Veterinary and human toxicology. (1979) [Pubmed]
  6. Phytoremediation of methylmercury pollution: merB expression in Arabidopsis thaliana confers resistance to organomercurials. Bizily, S.P., Rugh, C.L., Summers, A.O., Meagher, R.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Purification and characterization of a novel organometallic receptor protein regulating the expression of the broad spectrum mercury-resistant operon of plasmid pDU1358. Yu, H., Mukhopadhyay, D., Misra, T.K. J. Biol. Chem. (1994) [Pubmed]
  8. Identification of the iron entry channels in apoferritin. Chemical modification and spectroscopic studies. Stefanini, S., Desideri, A., Vecchini, P., Drakenberg, T., Chiancone, E. Biochemistry (1989) [Pubmed]
  9. Mercury operon regulation by the merR gene of the organomercurial resistance system of plasmid pDU1358. Nucifora, G., Chu, L., Silver, S., Misra, T.K. J. Bacteriol. (1989) [Pubmed]
  10. Properties of six pesticide degradation plasmids isolated from Alcaligenes paradoxus and Alcaligenes eutrophus. Don, R.H., Pemberton, J.M. J. Bacteriol. (1981) [Pubmed]
  11. Effects of germanium oxide and other chemical compounds on phenylmercury acetate-induced genotoxicity in cultured human lymphocytes. Lee, C.H., Lin, R.H., Liu, S.H., Lin-Shiau, S.Y. Environ. Mol. Mutagen. (1998) [Pubmed]
  12. Comparative effects of inorganic divalent mercury, methylmercury and phenylmercury on membrane excitability and synaptic transmission of CA1 neurons in hippocampal slices of the rat. Yuan, Y., Atchison, W.D. Neurotoxicology (1994) [Pubmed]
  13. Quantitative evaluation of the spermicidal potencies of vaginal contraceptives with a transmembrane migration method. Hong, C.Y., Chiang, B.N., Wu, P. Clinical reproduction and fertility. (1983) [Pubmed]
  14. Distinct genotoxicity of phenylmercury acetate in human lymphocytes as compared with other mercury compounds. Lee, C.H., Lin, R.H., Liu, S.H., Lin-Shiau, S.Y. Mutat. Res. (1997) [Pubmed]
  15. Investigations on the mutagenicity of two organomercurial pesticides, Ceresan and Agallol 3, in Drosophila melanogaster. Gayathri, M.V., Krishnamurthy, N.B. Environmental research. (1985) [Pubmed]
  16. The effect of intoxication by ceresan on the activity of phosphatases and esterases in the rat thalamus. Wigowska-Sowińska, J. Folia histochemica et cytochemica. (1980) [Pubmed]
  17. Influence of chronic administration of phenylmercuric acetate on the peripheral nerve system of rat. Slizewski, M. Neuropatologia polska. (1975) [Pubmed]
  18. Histoenzymatic changes in the thalamic nuclei of rats intoxicated by phenyl-mercury acetate (PhMA). Wigowska-Sowińska, J. Journal für Hirnforschung. (1981) [Pubmed]
  19. Cytotoxicity of mercurial preservatives in cell culture. Takahashi, N. Ophthalmic Res. (1982) [Pubmed]
  20. Effect of five pesticides on the mycelial growth of some soil and pathogenic fungi. El-Hissy, F.T., Abdel-Kader, M.I. Z. Allg. Mikrobiol. (1980) [Pubmed]
  21. Mercury compounds induce a rapid increase in procoagulant activity of monocyte-like U937 cells. Kaneko, H., Kakkar, V.V., Scully, M.F. Br. J. Haematol. (1994) [Pubmed]
  22. Regulation of the operon responsible for broad-spectrum mercury resistance in Streptomyces lividans 1326. Brünker, P., Rother, D., Sedlmeier, R., Klein, J., Mattes, R., Altenbuchner, J. Mol. Gen. Genet. (1996) [Pubmed]
  23. 13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins. Eisenreich, W., Kemter, K., Bacher, A., Mulrooney, S.B., Williams, C.H., Müller, F. Eur. J. Biochem. (2004) [Pubmed]
  24. Two electrogenic mechanisms contributing to the 560 nm absorption changes in intact Bryopsis chloroplasts. Satoh, K., Katoh, S. Biochim. Biophys. Acta (1979) [Pubmed]
  25. Nursing leader Rita Celmer: the spirit of emergency nursing. Interview by Mary Bailey. Celmer, R. Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association. (1993) [Pubmed]
  26. Serotonin production in lymphocytes and mercury intolerance. Marcusson, J.A., Cederbrant, K., Gunnarsson, L.G. Toxicology in vitro : an international journal published in association with BIBRA. (2000) [Pubmed]
  27. Copper intrauterine contraceptive device and pregnancy rate. Bontis, J., Vavilis, D., Theodoridis, T., Sidiropoulou, A. Advances in contraception : the official journal of the Society for the Advancement of Contraception. (1994) [Pubmed]
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