Disease relevance of phenylmercuric acetate

• A 7.9-kilobase (kb) chromosomal fragment was cloned from a mercury-resistant Bacillus sp. In Escherichia coli, in the presence of a second plasmid carrying functional transport genes, resistance to HgCl2 and to phenylmercury acetate (PMA) was expressed [1].
• Of a sample of 42 gram-negative Hg-resistant bacteria, three (a Pseudomonas fluorescens, a Klebsiella sp. and a Citrobacter sp.) contained translocatable elements conferring resistance to Hg2+ (all three) and to Hg2+ and phenylmercuric acetate (P. fluorescens) [2].
• Kosinostatin isomerizes to isoquinocycline B through the inversion of the stereocenter at C-2'. Comparison of physico-chemical properties indicated that kosinostatin is presumably identical with quinocycline B isolated by CELMER et al. from Streptomyces aureofaciens [3].
• Contact urticaria syndrome due to phenylmercuric acetate [4].
• Chronic phenylmercuric acetate toxicity in a horse [5].

High impact information on phenylmercuric acetate

• Transgenic plants expressing merBpe grew vigorously on a wide range of concentrations of monomethylmercuric chloride and phenylmercuric acetate [6].
• Phenylmercuric acetate did not induce mer operon expression when the MerRNS was used in the assay [7].
• The assignment of these effects to the carboxylate moiety of p-(chloromercuri)benzoate is brought out by the observation that the introduction in the 3-fold channel of the benzene ring only by means of phenylmercuric acetate has no effect on the initial iron uptake kinetics and on the spectroscopic properties of the Fe(III)-apoferritin complex [8].
• The structural basis for induction of the mercury resistance operon with inorganic mercury and with the organomercurial compound phenylmercuric acetate was addressed by DNA sequencing analysis and by lac fusion transcription experiments regulated by merR in trans from broad-spectrum-resistance plasmid pDU1358 (Hg2+ and phenylmercury responding) [9].
• In addition, these four plasmids conferred resistance to merbromin, phenylmercury acetate, and mercuric ions, had almost identical restriction endonuclease cleavage patterns, and encoded degradation of m-chlorobenzoate [10].

Biological context of phenylmercuric acetate

• Phenylmercury acetate (PMA), which not only causes an elevation of sister chromatid exchanges (SCEs) but also induces high frequency of endoreduplication in human lymphocytes, may be genotoxic to humans [11].
• Comparative effects of inorganic mercury (Hg2+), methylmercury (MeHg) and phenylmercuric acetate (PMA) on central synaptic transmission were examined by recording field potentials from CA1 neurons of rat hippocampal slices before and after acute bath application of mercurials at 20 and 100 microM [12].
• The maximal dilutions that decreased sperm motility to 50% of control for Delfen, Samtol, Lorophyn and Ortho-Gynol were 240, 160, 75 and 35 respectively [13].

Anatomical context of phenylmercuric acetate

• Distinct genotoxicity of phenylmercury acetate in human lymphocytes as compared with other mercury compounds [14].
• Broodwise analysis revealed that spermatids and spermatocytes were more sensitive than others to all the concentrations of Ceresan and Agallol 3 used [15].
• The changes in the histoenzymatic pattern of the thalamus caused by Ceresan ingestion were topographically highly differentiated [16].
• Influence of chronic administration of phenylmercuric acetate on the peripheral nerve system of rat [17].
• The effect of ingestion of phenylmercury acetate (PhMA), a fungicide of wide agricultural application, on the histoenzymatic pattern of the thalamic nuclei was investigated [18].

Associations of phenylmercuric acetate with other chemical compounds

• Two organomercurial fungicides, Ceresan containing phenyl mercury acetate and Agallol 3 containing methoxyethyl mercury chloride, were investigated for their mutagenicity in Drosophila melanogaster [15].
• The cytotoxicity of two kinds of mercurial preservatives, thimerosal and phenylmercuric acetate, was studied using Chang's human conjunctival epithelia in cell culture [19].
• The effect of three doses (the lowest is the recommended dose in the field) of 5 pesticides namely: Ceresan, Orthocid (fungicides), VCS-438 (herbicide), and Dursban and Dipterex (insecticides) on the mycelial dry weight of Aspergillus fumigatus [20].

Gene context of phenylmercuric acetate

• Two other heavy metal compounds, AgNO3 and phenylmercuric acetate, caused a similar increase in TF activity [21].
• Addition of mercuric ions and phenylmercuric acetate prevented the binding of MerR [22].
• Thioredoxin reductase (TrxR) from Escherichia coli, the mutant proteins E159Y and C138S, and the mutant protein C138S treated with phenylmercuric acetate were reconstituted with [U-(13)C(17),U-(15)N(4)]FAD and analysed, in their oxidized and reduced states, by (13)C-, (15)N- and (31)P-NMR spectroscopy [23].
• The magnitude of component R was markedly reduced by phenylmercuric acetate, suggesting the participation of ferredoxin and ferredoxin-NADP oxidoreductase in the mechanism of the field formation responsible for this component [24].
• Nursing leader Rita Celmer: the spirit of emergency nursing. Interview by Mary Bailey [25].

Analytical, diagnostic and therapeutic context of phenylmercuric acetate

• Patients with suspected illness due to mercury in dental amalgam were classified as tolerant or intolerant depending on their psychosomatic responses following in vivo epicutaneous provocation with low doses (patch test doses) of metallic mercury and phenylmercuric acetate [26].
• Between August 1983 and August 1992, 1995 women aged 20-43 years were fitted with 2736 copper intrauterine contraceptive devices (MLCu250, MLCu375, Nova-T, Gravigard, Anticon) [27].

References