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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

CALCIUM     calcium

Synonyms: Kalzium, calcium(0), HSDB 273, AG-B-57942, CHEMBL2146121, ...
 
 
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Disease relevance of calcium

 

Psychiatry related information on calcium

 

High impact information on calcium

 

Chemical compound and disease context of calcium

 

Biological context of calcium

  • Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes [18].
  • The current study tests the hypothesis that expression of genes encoding proteins regulating myocardial Ca2+ homeostasis is altered in human heart failure [19].
  • Because the incidence of ALS-G and PD-G has been associated with prolonged exposure to an environment severely deficient in Ca2+ and Mg2+, we propose that this variant TRPM7 allele confers a susceptibility genotype in such an environment [1].
  • We now report the cloning of a brain-enriched gene, CalDAG-GEFI, which has substrate specificity for Rap1A, dual binding domains for calcium (Ca2+) and diacylglycerol (DAG), and enriched expression in brain basal ganglia pathways and their axon-terminal regions [20].
  • Thus, although differentiation of HL-60 to the monocytic phenotype by 1,25-(OH)2D3 is Ca2+-independent, expression of response to regulatory stimuli requires priming of cellular Ca2+ stores [21].
 

Anatomical context of calcium

  • Altered expression of these genes may be related to abnormal Ca2+ handling in the failing myocardium, contributing to LV systolic and diastolic dysfunction in patients with end-stage heart failure [19].
  • Present data indicate a direct cardiac depressant action of gentamicin, and suggest that this antibiotic adversely affects either the transport system responsible for Ca++ movement through slow channels of the sarcolemma, the availability of Ca++ for translocation to these sites, or both [22].
  • CONCLUSIONS: TUDCA at physiological concentrations potently modulates (Ca2+)i signals in hepatocytes by (1) mobilizing microsomal IP3-sensitive Ca2+ stores by an IP3-independent mechanism, (2) initiating Ca2+ oscillations, and (3) inducing influx of extracellular Ca2+ [23].
  • Na+/Ca2+ exchanger modulates kainate-triggered Ca2+ signaling in Bergmann glial cells in situ [24].
  • Proton inactivation of Ca2+ transport by sarcoplasmic reticulum [25].
 

Associations of calcium with other chemical compounds

 

Gene context of calcium

 

Analytical, diagnostic and therapeutic context of calcium

  • Calcium ion-selective microelectrodes made with Simon's neutral carrier were used to measure simultaneously sarcoplasmic Ca2+ activity (aiCa) and resting tension (Tr) of rabbit ventricular muscle during reduction and restoration of external sodium ion concentration, [Na]0 [35].
  • Calcium ion flux was monitored in individual cells by flow cytometry using the indicator indo-1 AM [3].
  • Calcium ion titration was also found to induce shifts in the NeuNAc 13C resonances that may be of functional significance [36].
  • One major manifestation of alpha 1-adrenergic receptor activation during reperfusion of ischemic myocardium is an increase in intracellular calcium ion (Ca2+) [37].
  • Eight patients were further investigated using surface plasmon resonance (SPR) for antibody binding to covalently bound FXII and to covalently bound prothrombin in both Ca++ dependent and independent systems [38].

References

  1. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Hermosura, M.C., Nayakanti, H., Dorovkov, M.V., Calderon, F.R., Ryazanov, A.G., Haymer, D.S., Garruto, R.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Barger, S.W., Hörster, D., Furukawa, K., Goodman, Y., Krieglstein, J., Mattson, M.P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Neuropeptide stimulation of calcium flux in human lung cancer cells: delineation of alternative pathways. Bunn, P.A., Dienhart, D.G., Chan, D., Puck, T.T., Tagawa, M., Jewett, P.B., Braunschweiger, E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Abnormalities of cytoplasmic Ca2+ in platelets from patients with uremia. Ware, J.A., Clark, B.A., Smith, M., Salzman, E.W. Blood (1989) [Pubmed]
  5. Calcium ion modulation of meizothrombin autolysis at Arg55-Asp56 and catalytic activity. Stevens, W.K., Côté, H.F., MacGillivray, R.T., Nesheim, M.E. J. Biol. Chem. (1996) [Pubmed]
  6. Calcium ion transients in neutrophils from patients with sporadic Alzheimer's disease. Garlind, A., Nilsson, E., Palmblad, J. Neurosci. Lett. (1998) [Pubmed]
  7. Relationship between erythrocyte magnesium, plasma electrolytes and cortisol, and intensity of symptoms in major depressed patients. Widmer, J., Henrotte, J.G., Raffin, Y., Bovier, P., Hilleret, H., Gaillard, J.M. Journal of affective disorders. (1995) [Pubmed]
  8. Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. Berchtold, M.W., Brinkmeier, H., Müntener, M. Physiol. Rev. (2000) [Pubmed]
  9. Calcium ion produces graded changes in permeability of membrane channels in cell junction. Rose, B., Simpson, I., Loewenstein, W.R. Nature (1977) [Pubmed]
  10. Spatially and functionally distinct Ca2+ stores in sarcoplasmic and endoplasmic reticulum. Golovina, V.A., Blaustein, M.P. Science (1997) [Pubmed]
  11. Endocytotic sucrose uptake in Amoeba proteus induced with the calcium ionophore A23187. Prusch, R.D. Science (1980) [Pubmed]
  12. Calcium ion distribution in cytoplasm visualised by aequorin: diffusion in cytosol restricted by energized sequestering. Rose, B., Loewenstein, W.R. Science (1975) [Pubmed]
  13. Beneficial effects of diltiazem on the natural history of hypertensive diabetic cardiomyopathy in rats. Fein, F.S., Cho, S., Malhotra, A., Akella, J., vanHoeven, K.H., Sonnenblick, E.H., Factor, S.M. J. Am. Coll. Cardiol. (1991) [Pubmed]
  14. Ability of 25-hydroxyvitamin D3 therapy to augment serum 1,25- and 24,25-dihydroxyvitamin D in postmenopausal osteoporosis. Lawoyin, S., Zerwekh, J.E., Glass, K., Pak, C.Y. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  15. A critical role for enhanced TGF-alpha and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease. Cozzolino, M., Lu, Y., Sato, T., Yang, J., Suarez, I.G., Brancaccio, D., Slatopolsky, E., Dusso, A.S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  16. Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres. Horiuti, K. J. Physiol. (Lond.) (1988) [Pubmed]
  17. Potential nephrotoxicity of intravenous infusions of naftidrofuryl oxalate. Le Meur, Y., Moesch, C., Rincé, M., Aldigier, J.C., Leroux-Robert, C. Nephrol. Dial. Transplant. (1995) [Pubmed]
  18. Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. Allbritton, N.L., Verret, C.R., Wolley, R.C., Eisen, H.N. J. Exp. Med. (1988) [Pubmed]
  19. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. Takahashi, T., Allen, P.D., Lacro, R.V., Marks, A.R., Dennis, A.R., Schoen, F.J., Grossman, W., Marsh, J.D., Izumo, S. J. Clin. Invest. (1992) [Pubmed]
  20. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Kawasaki, H., Springett, G.M., Toki, S., Canales, J.J., Harlan, P., Blumenstiel, J.P., Chen, E.J., Bany, I.A., Mochizuki, N., Ashbacher, A., Matsuda, M., Housman, D.E., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line. Hruska, K.A., Bar-Shavit, Z., Malone, J.D., Teitelbaum, S. J. Biol. Chem. (1988) [Pubmed]
  22. Gentamicin blockade of slow Ca++ channels in atrial myocardium of guinea pigs. Adams, H.R., Durrett, L.R. J. Clin. Invest. (1978) [Pubmed]
  23. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Beuers, U., Nathanson, M.H., Boyer, J.L. Gastroenterology (1993) [Pubmed]
  24. Na+/Ca2+ exchanger modulates kainate-triggered Ca2+ signaling in Bergmann glial cells in situ. Kirischuk, S., Kettenmann, H., Verkhratsky, A. FASEB J. (1997) [Pubmed]
  25. Proton inactivation of Ca2+ transport by sarcoplasmic reticulum. Berman, M.C., McIntosh, D.B., Kench, J.E. J. Biol. Chem. (1977) [Pubmed]
  26. Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury. Smith-Swintosky, V.L., Zimmer, S., Fenton, J.W., Mattson, M.P. J. Neurosci. (1995) [Pubmed]
  27. Intralymphocyte free magnesium in a group of subjects with essential hypertension. Delva, P.T., Pastori, C., Degan, M., Montesi, G.D., Lechi, A. Hypertension (1996) [Pubmed]
  28. The ATP-induced inward current in mouse lacrimal acinar cells is potentiated by isoprenaline and GTP. Sasaki, T., Gallacher, D.V. J. Physiol. (Lond.) (1992) [Pubmed]
  29. Calcium ion-dependent adenosine triphosphatase activity and plasma-membrane phosphorylation in the human neutrophil. Schneider, C., Mottola, C., Romeo, D. Biochem. J. (1979) [Pubmed]
  30. The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta. Wellner, M., Maasch, C., Kupprion, C., Lindschau, C., Luft, F.C., Haller, H. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  31. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Kershaw, M.H., Wang, G., Westwood, J.A., Pachynski, R.K., Tiffany, H.L., Marincola, F.M., Wang, E., Young, H.A., Murphy, P.M., Hwu, P. Hum. Gene Ther. (2002) [Pubmed]
  32. Homotypic and heterotypic Ca(++)-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface. Oikawa, S., Kuroki, M., Matsuoka, Y., Kosaki, G., Nakazato, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  33. Calcium ion promotes yeast Dmc1 activity via formation of long and fine helical filaments with single-stranded DNA. Lee, M.H., Chang, Y.C., Hong, E.L., Grubb, J., Chang, C.S., Bishop, D.K., Wang, T.F. J. Biol. Chem. (2005) [Pubmed]
  34. Somatostatin blocks Ca2+ action potential activity in prolactin-secreting pituitary tumor cells through coordinate actions on K+ and Ca2+ conductances. Mollard, P., Vacher, P., Dufy, B., Barker, J.L. Endocrinology (1988) [Pubmed]
  35. Sodium-calcium exchange in rabbit heart muscle cells: direct measurement of sarcoplasmic Ca2+ activity. Lee, C.O., Uhm, D.Y., Dresdner, K. Science (1980) [Pubmed]
  36. Chemical and carbon-13 nuclear magnetic resonance studies of the blood group M and N active sialoglycopeptides from human glycophorin A. Prohaska, R., Koerner, T.A., Armitage, I.M., Furthmayr, H. J. Biol. Chem. (1981) [Pubmed]
  37. Mechanisms contributing to the arrhythmogenic influences of alpha 1-adrenergic stimulation in the ischemic heart. Corr, P.B., Heathers, G.P., Yamada, K.A. Am. J. Med. (1989) [Pubmed]
  38. Antibodies to factor XII are distinct from antibodies to prothrombin in patients with the anti-phospholipid syndrome. Jone, D.W., Nicholls, P.J., Donohoe, S., Gallimore, M.J., Winter, M. Thromb. Haemost. (2002) [Pubmed]
 
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