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Chemical Compound Review

Lederfen     4-oxo-4-(4- phenylphenyl)butanoic acid

Synonyms: fenbufen, Bufemid, Cinopal, Cinopol, Fenbufene, ...
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Analytical, diagnostic and therapeutic context of Napanol

  • No cases of drug-related jaundice have been reported either in clinical trials or from countries where fenbufen is marketed [2].
  • 1. Interaction of quinolone antibiotics and the anti-inflammatory agent fenbufen with the gamma-aminobutyric acid-A (GABAA) receptor-chloride channel complex in pyramidal neurons freshly dissociated from the hippocampal CA1 region of the rats was investigated in whole-cell mode, using the patch-clamp technique under voltage-clamp conditions [25].
  • High-performance liquid chromatography assay for fenbufen and two serum metabolites [26].
  • In a randomized, double-blind crossover study patients received 75 mg of indomethacin daily or 600 mg of fenbufen daily for six weeks and then were treated with the alternate regimen for a similar period [27].
  • Improved dissolution behavior of fenbufen by spherical crystallization [28].


  1. Overview of efficacy of fenbufen in rheumatoid arthritis and osteoarthritis. Bernstein, J. Am. J. Med. (1983) [Pubmed]
  2. Side effect and safety data for fenbufen. Crossley, R.J. Am. J. Med. (1983) [Pubmed]
  3. Kinetics of single doses of fenbufen in patients with renal insufficiency. Rogers, H.J., Savitsky, J.P., Glenn, B., Spector, R.G. Clin. Pharmacol. Ther. (1981) [Pubmed]
  4. Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.S. Drugs (1981) [Pubmed]
  5. Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. Taguchi, M., Kondo, H., Inoue, Y., Kawahata, Y., Jinbo, Y., Sakamoto, F., Tsukamoto, G. J. Med. Chem. (1992) [Pubmed]
  6. Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation. Lanza, F.L., Nelson, R.S., Greenberg, B.P. Am. J. Med. (1983) [Pubmed]
  7. Pharmacologic properties of fenbufen. Kerwar, S.S. Am. J. Med. (1983) [Pubmed]
  8. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs. Child, R.G., Osterberg, A.C., Sloboda, A.E., Tomcufcik, A.S. Journal of pharmaceutical sciences. (1977) [Pubmed]
  9. A single-blind cross-over comparison of fenbufen 600 mg nocte and piroxicam 20 mg nocte in osteoarthritis. Wade, A.G. European journal of rheumatology and inflammation. (1981) [Pubmed]
  10. Clinical comparison of fenbufen and aspirin in osteoarthritis. Valtonen, E.J. Scand. J. Rheumatol. Suppl. (1979) [Pubmed]
  11. Hippocampal activity in the presence of quinolones and fenbufen in vitro. Dimpfel, W., Spüler, M., Dalhoff, A., Hofmann, W., Schlüter, G. Antimicrob. Agents Chemother. (1991) [Pubmed]
  12. Effect of the cyclo-oxygenase inhibitor fenbufen on muscle and liver protein metabolism, muscle glutamine and plasma insulin in endotoxaemic rats. Jepson, M.M., Millward, D.J. Clin. Sci. (1989) [Pubmed]
  13. Absence of pharmacokinetic interaction between ofloxacin and fenbufen in rats. Katagiri, Y., Naora, K., Ichikawa, N., Hayashibara, M., Iwamoto, K. J. Pharm. Pharmacol. (1989) [Pubmed]
  14. Pharmacokinetics of fenbufen in man. Cuisinaud, G., Legheand, J., Llorca, G., Belkahia, C., Lejeune, E., Sassard, J. Eur. J. Clin. Pharmacol. (1979) [Pubmed]
  15. Assessment of the effects of combination therapy with ciprofloxacin and fenbufen on the central nervous systems of healthy volunteers by quantitative electroencephalography. Kamali, F., Ashton, C.H., Marsh, V.R., Cox, J. Antimicrob. Agents Chemother. (1998) [Pubmed]
  16. Metabolism of fenbufen by cultured 3T3-L1 adipocytes: synthesis and metabolism of xenobiotic glycerolipids. Dodds, P.F., Chou, S.C., Ranasinghe, A., Coleman, R.A. J. Lipid Res. (1995) [Pubmed]
  17. Effect of fenbufen on the penetration of quinolone antibiotics into cerebrospinal fluid. Comparative study with 5 quinolones. Iwamoto, K., Ichikawa, N., Naora, K., Hirano, H. Drugs (1995) [Pubmed]
  18. Effect of the anti-inflammatory agent fenbufen on the quinolone-induced inhibition of gamma-aminobutyric acid binding to rat brain membranes in vitro. Tsuji, A., Sato, H., Okezaki, E., Nagata, O., Kato, H. Biochem. Pharmacol. (1988) [Pubmed]
  19. Effect of fenbufen on the pharmacokinetics of sparfloxacin in rats. Naora, K., Katagiri, Y., Iwamoto, K., Tanaka, K., Yamaguchi, T., Sekine, Y. J. Antimicrob. Chemother. (1992) [Pubmed]
  20. Simultaneous determination of ofloxacin, fenbufen and felbinac in rat plasma by high-performance liquid chromatography. Katagiri, Y., Naora, K., Ichikawa, N., Hayashibara, M., Iwamoto, K. J. Chromatogr. (1988) [Pubmed]
  21. A six-month parallel group comparison of fenbufen and naproxen in the treatment of rheumatoid arthritis. Khan, F.M. Clinical therapeutics. (1983) [Pubmed]
  22. A survey of clinical trials with fenbufen. Mawdsley, P. Arzneimittel-Forschung. (1980) [Pubmed]
  23. Quinolones do not interact with NMDA receptor in dissociated rat hippocampal neurons. Shirasaki, T., Harata, N., Nakaye, T., Akaike, N. Brain Res. (1991) [Pubmed]
  24. Effects of some anti-inflammatory drugs on biochemical values and on hepatic peroxisomal enzymes of rat. Watanabe, T., Suga, T. J. Pharmacobio-dyn. (1985) [Pubmed]
  25. Quinolones and fenbufen interact with GABAA receptor in dissociated hippocampal cells of rat. Akaike, N., Shirasaki, T., Yakushiji, T. J. Neurophysiol. (1991) [Pubmed]
  26. High-performance liquid chromatography assay for fenbufen and two serum metabolites. Fleitman, J.S., Schulman, S.G., Perrin, J.H. J. Chromatogr. (1982) [Pubmed]
  27. Fenbufen and indomethacin: a comparative study in rheumatoid arthritis. Burton, W.D., Hazleman, B.L. Clinical therapeutics. (1983) [Pubmed]
  28. Improved dissolution behavior of fenbufen by spherical crystallization. Di Martino, P., Barthélémy, C., Piva, F., Joiris, E., Palmieri, G.F., Martelli, S. Drug development and industrial pharmacy. (1999) [Pubmed]
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